94 items (Equus caballus) - STRING interaction network

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	LTA	Tumor necrosis factor ligand 1E; Belongs to the tumor necrosis factor family. (204 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
	TICAM1	Toll like receptor adaptor molecule 1. (698 aa)
	CARD11	Caspase recruitment domain family member 11. (1156 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
	PLAU	Plasminogen activator, urokinase. (433 aa)
	CARD14	Caspase recruitment domain family member 14. (1003 aa)
	EDARADD	EDAR associated death domain. (216 aa)
	LTB	Tumor necrosis factor ligand 1C; Belongs to the tumor necrosis factor family. (246 aa)
	TNFAIP3	TNF alpha induced protein 3. (794 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (671 aa)
	TLR4	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa)
	ZAP70	Tyrosine-protein kinase. (619 aa)
	TIRAP	TIR domain containing adaptor protein. (234 aa)
	TICAM2	TIR domain-containing protein. (238 aa)
	LOC111770212	C-C motif chemokine. (100 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
	TRADD	TNFRSF1A associated via death domain. (312 aa)
	MALT1	MALT1 paracaspase. (850 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (551 aa)
	LOC100063059	SCY domain-containing protein. (131 aa)
	CSNK2A2	Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (350 aa)
	LBP	Lipopolysaccharide binding protein. (481 aa)
	MAP3K14	Mitogen-activated protein kinase kinase kinase 14. (955 aa)
	IRAK4	Interleukin 1 receptor associated kinase 4. (460 aa)
	CXCL8	Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity). (101 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (1049 aa)
	BLNK	B cell linker. (467 aa)
	UBE2I	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (469 aa)
	TNFSF11	Tumor necrosis factor ligand superfamily member. (318 aa)
	CD40	Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (280 aa)
	TNFSF14	Tumor necrosis factor ligand 1D. (241 aa)
	LY96	Lymphocyte antigen 96. (173 aa)
	PTGS2	Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (666 aa)
	TAB2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
	TNFSF13B	Tumor necrosis factor superfamily member 13b; Belongs to the tumor necrosis factor family. (290 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa)
	CSNK2B	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (235 aa)
	LAT	Linker for activation of T cells. (238 aa)
	BTK	Tyrosine-protein kinase. (687 aa)
	CFLAR	CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (510 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
	DDX58	DExD/H-box helicase 58. (1021 aa)
	LCK	Tyrosine-protein kinase. (509 aa)
	GADD45G	Growth arrest and DNA damage inducible gamma. (159 aa)
	NFKBIA	NFKB inhibitor alpha. (543 aa)
	BCL10	BCL10 immune signaling adaptor. (374 aa)
	EDA	Ectodysplasin A; Belongs to the tumor necrosis factor family. (388 aa)
	PIAS4	Protein inhibitor of activated STAT 4. (536 aa)
	XIAP	X-linked inhibitor of apoptosis. (494 aa)
	VCAM1	Vascular cell adhesion molecule 1. (786 aa)
	IL1R1	Interleukin 1 receptor type 1. (578 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3076 aa)
	GADD45A	Growth arrest and DNA damage inducible alpha. (165 aa)
	ENSECAP00000026008	Ig-like domain-containing protein. (182 aa)
	LOC111767719	Ig-like domain-containing protein. (187 aa)
	LOC111772100	Ig-like domain-containing protein. (173 aa)
	BCL2L1	BCL2 like 1. (245 aa)
	LOC111768185	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
	TAB1	TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (654 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (770 aa)
	ERC1	ELKS/RAB6-interacting/CAST family member 1. (1120 aa)
	LOC111772122	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (369 aa)
	PLCG2	Phosphoinositide phospholipase C. (1331 aa)
	PIDD1	P53-induced death domain protein 1. (915 aa)
	CCL13	SCY domain-containing protein. (264 aa)
	NFKB2	Nuclear factor kappa B subunit 2. (1024 aa)
	PARP1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (811 aa)
	SYK	Tyrosine-protein kinase. (716 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
	LTBR	Lymphotoxin beta receptor. (434 aa)
	ICAM1	Intercellular adhesion molecule 1. (628 aa)
	GADD45B	Growth arrest and DNA damage inducible beta. (274 aa)
	TNFRSF13C	B cell-activating factor receptor. (183 aa)
	CXCL1	C-X-C motif chemokine. (113 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
	LOC106783094	Ig-like domain-containing protein. (229 aa)
	LYN	Tyrosine-protein kinase. (533 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
	CSNK2A1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (464 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (805 aa)
	TAB3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (717 aa)
	TRAF1	TNF receptor-associated factor. (415 aa)
	CCL4	SCY domain-containing protein. (97 aa)
	BCL2A1	BCL2 related protein A1. (231 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
	TNFRSF11A	TNF receptor superfamily member 11a. (647 aa)
	CYLD	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (268 aa)
	CXCL12	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
	TNFRSF1A	TNF receptor superfamily member 1A. (475 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	CHUK	ENSECAP00000025893	ENSECAP00000036997	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Component of inhibitor of nuclear factor kappa B kinase complex.	0.401
ATM	GADD45A	ENSECAP00000025893	ENSECAP00000025993	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Growth arrest and DNA damage inducible alpha.	0.454
ATM	IKBKB	ENSECAP00000025893	ENSECAP00000030412	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.413
ATM	IKBKG	ENSECAP00000025893	ENSECAP00000018204	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.662
ATM	NFKB1	ENSECAP00000025893	ENSECAP00000013133	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Nuclear factor kappa B subunit 1.	0.454
ATM	PARP1	ENSECAP00000025893	ENSECAP00000034666	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.629
ATM	PIAS4	ENSECAP00000025893	ENSECAP00000023796	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Protein inhibitor of activated STAT 4.	0.725
ATM	PIDD1	ENSECAP00000025893	ENSECAP00000032416	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	P53-induced death domain protein 1.	0.879
ATM	UBE2I	ENSECAP00000025893	ENSECAP00000013531	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.515
BCL10	CARD11	ENSECAP00000022572	ENSECAP00000004938	BCL10 immune signaling adaptor.	Caspase recruitment domain family member 11.	0.998
BCL10	CARD14	ENSECAP00000022572	ENSECAP00000005701	BCL10 immune signaling adaptor.	Caspase recruitment domain family member 14.	0.829
BCL10	CHUK	ENSECAP00000022572	ENSECAP00000036997	BCL10 immune signaling adaptor.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.977
BCL10	CYLD	ENSECAP00000022572	ENSECAP00000053024	BCL10 immune signaling adaptor.	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	0.556
BCL10	DDX58	ENSECAP00000022572	ENSECAP00000019669	BCL10 immune signaling adaptor.	DExD/H-box helicase 58.	0.415
BCL10	IKBKB	ENSECAP00000022572	ENSECAP00000030412	BCL10 immune signaling adaptor.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.979
BCL10	IKBKG	ENSECAP00000022572	ENSECAP00000018204	BCL10 immune signaling adaptor.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.982
BCL10	MALT1	ENSECAP00000022572	ENSECAP00000011434	BCL10 immune signaling adaptor.	MALT1 paracaspase.	0.999
BCL10	NFKB1	ENSECAP00000022572	ENSECAP00000013133	BCL10 immune signaling adaptor.	Nuclear factor kappa B subunit 1.	0.627
BCL10	NFKB2	ENSECAP00000022572	ENSECAP00000034177	BCL10 immune signaling adaptor.	Nuclear factor kappa B subunit 2.	0.448
BCL10	NFKBIA	ENSECAP00000022572	ENSECAP00000020980	BCL10 immune signaling adaptor.	NFKB inhibitor alpha.	0.550