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| | DEGS1 | Delta 4-desaturase, sphingolipid 1. (323 aa) |
| | GNAI1 | G protein subunit alpha i1. (354 aa) |
| | GNAI2 | G protein subunit alpha i2. (355 aa) |
| | S1PR4 | Sphingosine-1-phosphate receptor 4. (542 aa) |
| | NSMAF | Neutral sphingomyelinase activation associated factor. (920 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa) |
| | S1PR3 | Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (378 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa) |
| | S1PR2 | Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa) |
| | BDKRB2 | Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (414 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (364 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (194 aa) |
| | ASAH2 | Neutral ceramidase. (799 aa) |
| | ABCC1 | ATP binding cassette subfamily C member 1. (1540 aa) |
| | SPHK2 | Sphingosine kinase 2. (654 aa) |
| | CERS5 | Ceramide synthase 5. (452 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | FCER1A | High affinity immunoglobulin E receptor alpha subunit. (255 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase. (528 aa) |
| | FCER1G | Fc fragment of IgE receptor Ig. (86 aa) |
| | MAP2K2 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | GNAI3 | G protein subunit alpha i3. (354 aa) |
| | ROCK2 | Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1468 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (475 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (309 aa) |
| | S1PR1 | Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa) |
| | PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa) |
| | SMPD1 | Sphingomyelin phosphodiesterase 1. (824 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa) |
| | SGPP1 | Sphingosine-1-phosphate phosphatase 1. (443 aa) |
| | TRADD | TNFRSF1A associated via death domain. (312 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (551 aa) |
| | PPP2R2C | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | PPP2R3A | Protein phosphatase 2 regulatory subunit B''alpha. (1149 aa) |
| | PLD2 | Phospholipase. (933 aa) |
| | PPP2R3C | Protein phosphatase 2 regulatory subunit B''gamma. (453 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (1049 aa) |
| | PPP2R5B | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (542 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (192 aa) |
| | SMPD2 | Sphingomyelin phosphodiesterase 2. (423 aa) |
| | ACER2 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (274 aa) |
| | PTEN | Phosphatase and tensin homolog. (576 aa) |
| | GNA13 | G protein subunit alpha 13. (377 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (365 aa) |
| | ADORA1 | Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa) |
| | GNAQ | G protein subunit alpha q. (441 aa) |
| | CERS2 | Ceramide synthase 2. (652 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa) |
| | SGMS2 | Sphingomyelin synthase 2. (409 aa) |
| | ROCK1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa) |
| | OPRD1 | Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (372 aa) |
| | ACER1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa) |
| | SGPP2 | Sphingosine-1-phosphate phosphatase 2. (391 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | NOS3 | Nitric oxide synthase; Produces nitric oxide (NO). (1267 aa) |
| | PIK3R2 | Uncharacterized protein. (479 aa) |
| | ENSECAP00000024650 | Uncharacterized protein. (88 aa) |
| | SPTLC3 | Serine palmitoyltransferase long chain base subunit 3. (592 aa) |
| | DEGS2 | Delta 4-desaturase, sphingolipid 2. (455 aa) |
| | CERS6 | Ceramide synthase 6. (392 aa) |
| | GNA12 | G protein subunit alpha 12. (455 aa) |
| | SPTLC1 | Serine palmitoyltransferase long chain base subunit 1. (474 aa) |
| | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1236 aa) |
| | LOC100052122 | Uncharacterized protein. (461 aa) |
| | S1PR5 | Sphingosine-1-phosphate receptor 5. (396 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (446 aa) |
| | SGPL1 | Sphingosine-1-phosphate lyase 1. (610 aa) |
| | RAC1 | Rac family small GTPase 1. (221 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa) |
| | GAB2 | GRB2 associated binding protein 2. (708 aa) |
| | RAC2 | Rac family small GTPase 2. (192 aa) |
| | PRKCZ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (591 aa) |
| | RHOA | Transforming protein RhoA-like protein. (193 aa) |
| | CERS3 | Ceramide synthase 3. (386 aa) |
| | PPP2R2D | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (682 aa) |
| | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5. (1362 aa) |
| | PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (595 aa) |
| | CTSD | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (536 aa) |
| | MS4A2 | Membrane spanning 4-domains A2. (240 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (421 aa) |
| | PPP2R2A | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa) |
| | SPHK1 | Sphingosine kinase 1. (459 aa) |
| | PPP2R1B | Protein phosphatase 2 scaffold subunit Abeta. (783 aa) |
| | PLD1 | Phospholipase. (1189 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1. (585 aa) |
| | PPP2R5A | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (519 aa) |
| | LOC111770943 | N-acylsphingosine amidohydrolase 1; Belongs to the acid ceramidase family. (395 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa) |
| | PPP2R1A | Protein phosphatase 2 scaffold subunit Aalpha. (666 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | PPP2R3B | EF-hand domain-containing protein. (801 aa) |
| | KNG1 | Kininogen 1. (653 aa) |
| | TMIGD3 | Transmembrane and immunoglobulin domain containing 3; Belongs to the G-protein coupled receptor 1 family. (347 aa) |
| | PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1273 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (475 aa) |
