(104 nodes) Oocyte meiosis network (Equus caballus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ANAPC11	RING-type domain-containing protein. (84 aa)
	LOC100061391	Uncharacterized protein. (239 aa)
	SKP1	S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa)
	YWHAQ	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (245 aa)
	MAPK11	Mitogen-activated protein kinase. (364 aa)
	CALML3	Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
	YWHAG	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
	MAD2L2	Mitotic arrest deficient 2 like 2. (233 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (525 aa)
	CALM1	Uncharacterized protein; Belongs to the calmodulin family. (336 aa)
	PTTG1	Uncharacterized protein. (202 aa)
	YWHAE	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (312 aa)
	AR	Androgen receptor. (882 aa)
	CUL1	Cullin 1; Belongs to the cullin family. (776 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
	PPP1CA	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	PPP2R5E	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (475 aa)
	PPP2CB	Serine/threonine-protein phosphatase. (309 aa)
	FBXO5	F-box protein 5. (449 aa)
	PGR	Progesterone receptor. (934 aa)
	CDC23	Cell division cycle 23. (597 aa)
	PLCZ1-2	Phosphoinositide phospholipase C. (619 aa)
	RPS6KA3	Ribosomal protein S6 kinase. (747 aa)
	SGO1	Shugoshin 1. (529 aa)
	MAD2L1	Mitotic arrest deficient 2 like 1. (205 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
	YWHAH	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	CCNB1	Cyclin B1; Belongs to the cyclin family. (423 aa)
	PPP2R5B	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (542 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
	CPEB1	Uncharacterized protein. (561 aa)
	BUB1	BUB1 mitotic checkpoint serine/threonine kinase. (1076 aa)
	PPP1CC	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
	MAPK12	Mitogen-activated protein kinase. (365 aa)
	PLK1	Serine/threonine-protein kinase PLK. (604 aa)
	ANAPC4	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (808 aa)
	ANAPC2	Anaphase promoting complex subunit 2; Belongs to the cullin family. (823 aa)
	CDC20	Cell division cycle 20. (499 aa)
	CAMK2A	Calcium/calmodulin dependent protein kinase II alpha. (563 aa)
	YWHAB	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
	CCNE2	Cyclin E2; Belongs to the cyclin family. (404 aa)
	CDC16	Cell division cycle 16. (630 aa)
	CCNE1	Cyclin E1; Belongs to the cyclin family. (408 aa)
	CALML4	Calmodulin like 4. (197 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1367 aa)
	PKMYT1	Protein kinase, membrane associated tyrosine/threonine 1; Belongs to the protein kinase superfamily. (497 aa)
	SMC3	Structural maintenance of chromosomes protein. (1236 aa)
	ANAPC7	Anaphase promoting complex subunit 7. (598 aa)
	ESPL1	Extra spindle pole bodies like 1, separase. (2108 aa)
	ANAPC5	Anaphase promoting complex subunit 5. (755 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
	ANAPC10	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
	CAMK2D	Calcium/calmodulin dependent protein kinase II delta. (543 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1124 aa)
	REC8	REC8 meiotic recombination protein. (566 aa)
	LOC111767487	Anaphase promoting complex subunit 1. (1944 aa)
	RPS6KA1	Ribosomal protein S6 kinase. (780 aa)
	MOS	MOS proto-oncogene, serine/threonine kinase; Belongs to the protein kinase superfamily. (350 aa)
	CDC27	Cell division cycle 27. (836 aa)
	YWHAZ	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (247 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
	SPDYA	Uncharacterized protein. (311 aa)
	BTRC	Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1206 aa)
	WDR92	Protein phosphatase 3 regulatory subunit B, alpha. (496 aa)
	CPEB4	Cytoplasmic polyadenylation element binding protein 4. (735 aa)
	RBX1	Ring-box 1. (108 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1200 aa)
	LOC111768043	Uncharacterized protein. (258 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (359 aa)
	CALML5	Calmodulin like 5. (149 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (534 aa)
	CDK1	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (373 aa)
	IGF1	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
	CPEB2	Cytoplasmic polyadenylation element binding protein 2. (1034 aa)
	CPEB3	Cytoplasmic polyadenylation element binding protein 3. (731 aa)
	SLK	STE20 like kinase. (1266 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (717 aa)
	SPDYC	Uncharacterized protein. (390 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
	CDC26	Cell division cycle 26. (85 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
	MAD1L1	Mitotic arrest deficient 1 like 1. (754 aa)
	MAPK13	Mitogen-activated protein kinase. (421 aa)
	ANAPC13	Anaphase promoting complex subunit 13. (74 aa)
	PPP2R1B	Protein phosphatase 2 scaffold subunit Abeta. (783 aa)
	CAMK2B	Calcium/calmodulin dependent protein kinase II beta. (656 aa)
	AURKA	Aurora kinase A; Belongs to the protein kinase superfamily. (423 aa)
	CAMK2G	Calcium/calmodulin dependent protein kinase II gamma. (556 aa)
	PPP2R5A	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (519 aa)
	SMC1B	Structural maintenance of chromosomes protein. (1288 aa)
	CDC25C	Cell division cycle 25C. (510 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa)
	SMC1A	Structural maintenance of chromosomes protein. (1401 aa)
	RPS6KA6	Ribosomal protein S6 kinase. (763 aa)
	PPP2R1A	Protein phosphatase 2 scaffold subunit Aalpha. (666 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
	RPS6KA2	Ribosomal protein S6 kinase. (758 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSECAP00000022626	ENSECAP00000014398	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.575
ADCY1	ADCY3	ENSECAP00000022626	ENSECAP00000028644	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.942
ADCY1	ADCY4	ENSECAP00000022626	ENSECAP00000011399	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.526
ADCY1	ADCY5	ENSECAP00000022626	ENSECAP00000008418	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.529
ADCY1	ADCY6	ENSECAP00000022626	ENSECAP00000027555	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.519
ADCY1	ADCY7	ENSECAP00000022626	ENSECAP00000037645	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.664
ADCY1	ADCY8	ENSECAP00000022626	ENSECAP00000022161	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.954
ADCY1	ADCY9	ENSECAP00000022626	ENSECAP00000021853	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.673
ADCY1	ANAPC5	ENSECAP00000022626	ENSECAP00000021633	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Anaphase promoting complex subunit 5.	0.672
ADCY1	ANAPC7	ENSECAP00000022626	ENSECAP00000020444	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Anaphase promoting complex subunit 7.	0.673
ADCY1	CALM1	ENSECAP00000022626	ENSECAP00000007162	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the calmodulin family.	0.933
ADCY1	CALML3	ENSECAP00000022626	ENSECAP00000004472	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 3; Belongs to the calmodulin family.	0.933
ADCY1	CALML4	ENSECAP00000022626	ENSECAP00000019278	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 4.	0.918
ADCY1	CALML5	ENSECAP00000022626	ENSECAP00000031692	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 5.	0.942
ADCY1	CAMK2A	ENSECAP00000022626	ENSECAP00000017835	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II alpha.	0.693
ADCY1	CAMK2B	ENSECAP00000022626	ENSECAP00000044176	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II beta.	0.700
ADCY1	CAMK2D	ENSECAP00000022626	ENSECAP00000021897	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II delta.	0.700
ADCY1	CAMK2G	ENSECAP00000022626	ENSECAP00000046181	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II gamma.	0.668
ADCY1	PRKACA	ENSECAP00000022626	ENSECAP00000030791	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.926
ADCY1	PRKACB	ENSECAP00000022626	ENSECAP00000039657	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.930