STRINGSTRING
CREB3 CREB3 G6PC G6PC RAB11B RAB11B FOXO1 FOXO1 CAB39L CAB39L ADIPOQ ADIPOQ IRS2 IRS2 IRS1 IRS1 PIK3CD PIK3CD CREB3L2 CREB3L2 SLC2A4 SLC2A4 AKT2 AKT2 ADIPOR1 ADIPOR1 INSR INSR TSC1 TSC1 CFTR CFTR PPP2R5E PPP2R5E PPP2CB PPP2CB PRKAG1 PRKAG1 IRS4 IRS4 RPS6KB2 RPS6KB2 CPT1B-2 CPT1B-2 PRKAG2 PRKAG2 PRKAA2 PRKAA2 PCK1 PCK1 RPS6KB1 RPS6KB1 PPP2R2C PPP2R2C LEPR LEPR SCD5 SCD5 SCD SCD PPP2R3A PPP2R3A STK11 STK11 LIPE LIPE GYS2 GYS2 PPP2R3C PPP2R3C CAB39 CAB39 PIK3CA PIK3CA ADRA1A ADRA1A PPP2R5B PPP2R5B ACACB ACACB CREB3L4 CREB3L4 PFKFB4 PFKFB4 STRADB STRADB PFKL PFKL ELAVL1 ELAVL1 CCNA1 CCNA1 AKT3 AKT3 PIK3R1 PIK3R1 PRKAB2 PRKAB2 IGF1R IGF1R TSC2 TSC2 TBC1D1 TBC1D1 PRKAA1 PRKAA1 EEF2K EEF2K AKT1S1 AKT1S1 CRTC2 CRTC2 STRADA STRADA G6PC3 G6PC3 PIK3CB PIK3CB FOXO3 FOXO3 INS INS PIK3R2 PIK3R2 PFKM PFKM PFKFB3 PFKFB3 RPTOR RPTOR PCK2 PCK2 CPT1C CPT1C SREBF1 SREBF1 CCND1 CCND1 PRKAB1 PRKAB1 G6PC2 G6PC2 CREB3L1 CREB3L1 RAB10 RAB10 CPT1A CPT1A SIRT1 SIRT1 PFKFB2 PFKFB2 LOC100052122 LOC100052122 PFKFB1 PFKFB1 CD36 CD36 IGF1 IGF1 CAMKK2 CAMKK2 AKT1 AKT1 EIF4EBP1 EIF4EBP1 LEP LEP PPARGC1A PPARGC1A PRKAG3 PRKAG3 LOC100069009 LOC100069009 PPP2R2D PPP2R2D PPP2R2B PPP2R2B ACACA ACACA RAB14 RAB14 PPP2R2A PPP2R2A HMGCR HMGCR GYS1 GYS1 PPP2R1B PPP2R1B ADIPOR2 ADIPOR2 PDPK1 PDPK1 PPP2R5A PPP2R5A MLYCD MLYCD HNF4A HNF4A PPP2R1A PPP2R1A MTOR MTOR CREB3L3 CREB3L3 CREB5 CREB5 FASN FASN PPP2R3B PPP2R3B EEF2 EEF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CREB3cAMP responsive element binding protein 3. (390 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
RAB11BRAB11B, member RAS oncogene family. (218 aa)
FOXO1Forkhead box O1. (651 aa)
CAB39LCalcium binding protein 39 like. (337 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (301 aa)
IRS2Insulin receptor substrate 2. (1401 aa)
IRS1Insulin receptor substrate 1. (1239 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
AKT2Non-specific serine/threonine protein kinase. (528 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
TSC1TSC complex subunit 1. (1232 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1541 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (475 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa)
IRS4Insulin receptor substrate 4. (1355 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa)
CPT1B-2Carnitine palmitoyltransferase 1B. (893 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (564 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
LEPRLeptin receptor. (1165 aa)
SCD5Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (330 aa)
SCDStearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. (359 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1149 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
LIPELipase E, hormone sensitive type. (813 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (703 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (453 aa)
CAB39Calcium binding protein 39. (373 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ADRA1AAdrenoceptor alpha 1A. (465 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (542 aa)
ACACBAcetyl-CoA carboxylase beta. (2453 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (393 aa)
PFKFB46-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4. (469 aa)
STRADBSTE20 related adaptor beta. (418 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (326 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (456 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (451 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
TSC2TSC complex subunit 2. (1817 aa)
TBC1D1TBC1 domain family member 1. (1281 aa)
PRKAA1Non-specific serine/threonine protein kinase. (633 aa)
EEF2KEukaryotic elongation factor 2 kinase. (725 aa)
AKT1S1AKT1 substrate 1. (276 aa)
CRTC2CREB regulated transcription coactivator 2. (684 aa)
STRADASTE20 related adaptor alpha. (431 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
FOXO3Forkhead box O3. (671 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
PIK3R2Uncharacterized protein. (479 aa)
PFKMATP-dependent 6-phosphofructokinase, muscle type; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (937 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3. (571 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1384 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (646 aa)
CPT1CCarnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (803 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1740 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (345 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (524 aa)
RAB10RAB10, member RAS oncogene family. (186 aa)
CPT1ACarnitine O-palmitoyltransferase 1, liver isoform; Belongs to the carnitine/choline acetyltransferase family. (1029 aa)
SIRT1Sirtuin 1. (737 aa)
PFKFB26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2. (538 aa)
LOC100052122Uncharacterized protein. (461 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (487 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (578 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (210 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (189 aa)
PPARGC1APPARG coactivator 1 alpha. (839 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (556 aa)
LOC100069009Uncharacterized protein. (571 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (682 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (595 aa)
ACACAAcetyl-CoA carboxylase alpha. (2396 aa)
RAB14RAB14, member RAS oncogene family. (260 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (901 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (826 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (783 aa)
ADIPOR2Adiponectin receptor 2. (386 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (585 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (519 aa)
MLYCDMalonyl-CoA decarboxylase. (568 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (666 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2573 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (468 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
FASNFatty acid synthase. (3470 aa)
PPP2R3BEF-hand domain-containing protein. (801 aa)
EEF2Eukaryotic translation elongation factor 2. (1091 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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