STRINGSTRING
CREB3 CREB3 FOXO1 FOXO1 ADIPOQ ADIPOQ IRS2 IRS2 SESN2 SESN2 EHMT2 EHMT2 ATF4 ATF4 IRS1 IRS1 PIK3CD PIK3CD CREB3L2 CREB3L2 KL KL HRAS HRAS AKT2 AKT2 ADIPOR1 ADIPOR1 INSR INSR TSC1 TSC1 ADCY5 ADCY5 PRKAG1 PRKAG1 IRS4 IRS4 SOD2 SOD2 RPS6KB2 RPS6KB2 PRKAG2 PRKAG2 PRKAA2 PRKAA2 ADCY4 ADCY4 ATG5 ATG5 NRAS NRAS RELA RELA RPS6KB1 RPS6KB1 STK11 STK11 PIK3CA PIK3CA NFKB1 NFKB1 CAMK4 CAMK4 BAX BAX ADCY2 ADCY2 CREB3L4 CREB3L4 APPL1 APPL1 SESN3 SESN3 ATG101 ATG101 EHMT1 EHMT1 KRAS KRAS AKT3 AKT3 EIF4E2 EIF4E2 PIK3R1 PIK3R1 PRKAB2 PRKAB2 ATF6B ATF6B IGF1R IGF1R TSC2 TSC2 PRKAA1 PRKAA1 AKT1S1 AKT1S1 ADCY9 ADCY9 PIK3CB PIK3CB FOXO3 FOXO3 INS INS ADCY8 ADCY8 ADCY1 ADCY1 PIK3R2 PIK3R2 RPTOR RPTOR ADCY6 ADCY6 PRKAB1 PRKAB1 CREB3L1 CREB3L1 ADCY3 ADCY3 ATF2 ATF2 SIRT1 SIRT1 PRKACA PRKACA LOC100052122 LOC100052122 TP53 TP53 IGF1 IGF1 CAMKK2 CAMKK2 AKT1 AKT1 EIF4EBP1 EIF4EBP1 PPARGC1A PPARGC1A PRKAG3 PRKAG3 ADCY7 ADCY7 LOC100069009 LOC100069009 PRKACB PRKACB CAT CAT ADIPOR2 ADIPOR2 SESN1 SESN1 RB1CC1 RB1CC1 MTOR MTOR CREB3L3 CREB3L3 CREB5 CREB5 EIF4E EIF4E
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CREB3cAMP responsive element binding protein 3. (390 aa)
FOXO1Forkhead box O1. (651 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (301 aa)
IRS2Insulin receptor substrate 2. (1401 aa)
SESN2Sestrin 2. (481 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1389 aa)
ATF4Activating transcription factor 4. (334 aa)
IRS1Insulin receptor substrate 1. (1239 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
KLKlotho. (1011 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
AKT2Non-specific serine/threonine protein kinase. (528 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
TSC1TSC complex subunit 1. (1232 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa)
IRS4Insulin receptor substrate 4. (1355 aa)
SOD2Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (564 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NFKB1Nuclear factor kappa B subunit 1. (1049 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (393 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (708 aa)
SESN3Sestrin 3. (488 aa)
ATG101Autophagy related 101. (218 aa)
EHMT1Euchromatic histone lysine methyltransferase 1. (1296 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (451 aa)
ATF6BActivating transcription factor 6 beta. (703 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
TSC2TSC complex subunit 2. (1817 aa)
PRKAA1Non-specific serine/threonine protein kinase. (633 aa)
AKT1S1AKT1 substrate 1. (276 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
FOXO3Forkhead box O3. (671 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1124 aa)
PIK3R2Uncharacterized protein. (479 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1384 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1206 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (345 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (524 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1200 aa)
ATF2Activating transcription factor 2. (512 aa)
SIRT1Sirtuin 1. (737 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (359 aa)
LOC100052122Uncharacterized protein. (461 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (578 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (210 aa)
PPARGC1APPARG coactivator 1 alpha. (839 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (556 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
LOC100069009Uncharacterized protein. (571 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
CATCatalase. (598 aa)
ADIPOR2Adiponectin receptor 2. (386 aa)
SESN1Sestrin 1. (551 aa)
RB1CC1RB1 inducible coiled-coil 1. (1637 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2573 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (468 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (236 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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