STRINGSTRING
PLXNA1 PLXNA1 GNAI1 GNAI1 SEMA7A SEMA7A PTCH1 PTCH1 GNAI2 GNAI2 SRPK3 SRPK3 EPHA5 EPHA5 LRRC4 LRRC4 FES FES CXCR4 CXCR4 PLXNA2 PLXNA2 EFNA4 EFNA4 SLIT3 SLIT3 RASA1 RASA1 SEMA3E SEMA3E MYL9 MYL9 PIK3CD PIK3CD UNC5A UNC5A EFNB3 EFNB3 PARD6G PARD6G HRAS HRAS SEMA3F SEMA3F SEMA4A SEMA4A PPP3CB PPP3CB EPHA2 EPHA2 WNT5A WNT5A SSH3 SSH3 GNAI3 GNAI3 SEMA4D SEMA4D ROCK2 ROCK2 EPHB3 EPHB3 NFATC4 NFATC4 MET MET NGEF NGEF EPHB4 EPHB4 NTN4 NTN4 EFNA5 EFNA5 SRC SRC EFNB1 EFNB1 UNC5D UNC5D EFNB2 EFNB2 SEMA3D SEMA3D PLXNA4 PLXNA4 SLIT1 SLIT1 EPHB1 EPHB1 NRAS NRAS SEMA3B SEMA3B EPHA4 EPHA4 ROBO3 ROBO3 MYL5 MYL5 MAPK3 MAPK3 SSH2 SSH2 PIK3CA PIK3CA SEMA4C SEMA4C ABLIM3 ABLIM3 WNT5B WNT5B ABLIM2 ABLIM2 SEMA6D SEMA6D PAK6 PAK6 PARD3 PARD3 NTN3 NTN3 FZD3 FZD3 PAK1 PAK1 WNT4 WNT4 NFATC2 NFATC2 KRAS KRAS UNC5C UNC5C CFL1 CFL1 CAMK2A CAMK2A PIK3R1 PIK3R1 PAK2 PAK2 RND1 RND1 GDF7 GDF7 SEMA3C SEMA3C EFNA1 EFNA1 PLCG1 PLCG1 ROCK1 ROCK1 EPHA7 EPHA7 LRRC4C LRRC4C SEMA3G SEMA3G SEMA4G SEMA4G SEMA4B SEMA4B EPHA8 EPHA8 SHH SHH TRPC6 TRPC6 EPHA3 EPHA3 TRPC5 TRPC5 EPHA1 EPHA1 CDK5 CDK5 PIK3CB PIK3CB CAMK2D CAMK2D PTPN11 PTPN11 NEO1 NEO1 GSK3B GSK3B BMPR2 BMPR2 NTN1 NTN1 PIK3R2 PIK3R2 CFL2 CFL2 CDC42 CDC42 RRAS RRAS BOC BOC PTK2 PTK2 PLXNC1 PLXNC1 PAK5 PAK5 NTNG2 NTNG2 PARD6A PARD6A WDR92 WDR92 PLXNA3 PLXNA3 DPYSL2 DPYSL2 SMO SMO NCK2 NCK2 RGS3 RGS3 EPHA6 EPHA6 ILK ILK SEMA3A SEMA3A TRPC1 TRPC1 SRGAP1 SRGAP1 LOC100052122 LOC100052122 ABL1 ABL1 PLCG2 PLCG2 PPP3CC PPP3CC NFATC3 NFATC3 LIMK2 LIMK2 TRPC4 TRPC4 EFNA2 EFNA2 EPHB6 EPHB6 RAC1 RAC1 PPP3CA PPP3CA NRP1 NRP1 PRKCA PRKCA RAC2 RAC2 PRKCZ PRKCZ RHOA RHOA PDK1 PDK1 RYK RYK PARD6B PARD6B DPYSL5 DPYSL5 SEMA6B SEMA6B LIMK1 LIMK1 BMP7 BMP7 RGMA RGMA SLIT2 SLIT2 PLXNB1 PLXNB1 PLXNB2 PLXNB2 SEMA6A SEMA6A L1CAM L1CAM CAMK2B CAMK2B SEMA5A SEMA5A ROBO2 ROBO2 ARHGEF12 ARHGEF12 TRPC3 TRPC3 CAMK2G CAMK2G ITGB1 ITGB1 UNC5B UNC5B MAPK1 MAPK1 SEMA4F SEMA4F SEMA5B SEMA5B EPHB2 EPHB2 ROBO1 ROBO1 SRGAP3 SRGAP3 RAF1 RAF1 MYL12A MYL12A CXCL12 CXCL12 DCC DCC SEMA6C SEMA6C
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLXNA1Plexin A1. (1911 aa)
GNAI1G protein subunit alpha i1. (354 aa)
SEMA7ASemaphorin 7A; Belongs to the semaphorin family. (664 aa)
PTCH1Patched 1. (1490 aa)
GNAI2G protein subunit alpha i2. (355 aa)
SRPK3Plexin B3. (1946 aa)
EPHA5EPH receptor A5. (1039 aa)
LRRC4Leucine rich repeat containing 4. (652 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (852 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
PLXNA2Plexin A2. (1922 aa)
EFNA4Ephrin A4; Belongs to the ephrin family. (204 aa)
SLIT3Slit guidance ligand 3. (1521 aa)
RASA1RAS p21 protein activator 1. (1041 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (776 aa)
MYL9Myosin light chain 9. (172 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
UNC5AUnc-5 netrin receptor A. (898 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (340 aa)
PARD6GPar-6 family cell polarity regulator gamma. (373 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (785 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (797 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
EPHA2EPH receptor A2. (975 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
SSH3Slingshot protein phosphatase 3. (764 aa)
GNAI3G protein subunit alpha i3. (354 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1468 aa)
EPHB3EPH receptor B3. (1000 aa)
NFATC4Nuclear factor of activated T cells 4. (932 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1412 aa)
NGEFNeuronal guanine nucleotide exchange factor. (787 aa)
EPHB4EPH receptor B4. (987 aa)
NTN4Netrin 4. (630 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
SRCTyrosine-protein kinase. (551 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (373 aa)
UNC5DUnc-5 netrin receptor D. (957 aa)
EFNB2Ephrin-B2; Belongs to the ephrin family. (333 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (937 aa)
PLXNA4Plexin A4. (1893 aa)
SLIT1Slit guidance ligand 1. (1534 aa)
EPHB1EPH receptor B1. (984 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (752 aa)
EPHA4EPH receptor A4. (949 aa)
ROBO3Roundabout guidance receptor 3. (1390 aa)
MYL5Myosin light chain 5. (126 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
SSH2Slingshot protein phosphatase 2. (1450 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (1000 aa)
ABLIM3Actin binding LIM protein family member 3. (683 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
ABLIM2Actin binding LIM protein family member 2. (801 aa)
SEMA6DSemaphorin 6D; Belongs to the semaphorin family. (1082 aa)
PAK6Non-specific serine/threonine protein kinase. (680 aa)
PARD3Par-3 family cell polarity regulator. (1360 aa)
NTN3Netrin 3. (580 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
NFATC2Nuclear factor of activated T cells 2. (915 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
UNC5CUnc-5 netrin receptor C. (931 aa)
CFL1Cofilin 1; Belongs to the actin-binding proteins ADF family. (166 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha. (563 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
RND1Rho family GTPase 1. (232 aa)
GDF7Growth differentiation factor 7. (452 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (751 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (317 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
EPHA7EPH receptor A7. (998 aa)
LRRC4CLeucine rich repeat containing 4C. (640 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (770 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (844 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (826 aa)
EPHA8EPH receptor A8. (1002 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
TRPC6Transient receptor potential cation channel subfamily C member 6; Belongs to the transient receptor (TC 1.A.4) family. (932 aa)
EPHA3EPH receptor A3. (984 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (974 aa)
EPHA1EPH receptor A1. (976 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (543 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (606 aa)
NEO1Neogenin 1. (1489 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (440 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
NTN1Netrin 1. (604 aa)
PIK3R2Uncharacterized protein. (479 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
CDC42Cell division control protein 42-like protein. (191 aa)
RRASRAS related. (220 aa)
BOCBOC cell adhesion associated, oncogene regulated. (1116 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1093 aa)
PLXNC1Plexin C1. (1559 aa)
PAK5Non-specific serine/threonine protein kinase. (718 aa)
NTNG2Netrin G2. (634 aa)
PARD6APar-6 family cell polarity regulator alpha. (346 aa)
WDR92Protein phosphatase 3 regulatory subunit B, alpha. (496 aa)
PLXNA3Plexin A3. (2102 aa)
DPYSL2Dihydropyrimidinase like 2. (677 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
NCK2Cytoplasmic protein. (380 aa)
RGS3Regulator of G protein signaling 3. (894 aa)
EPHA6EPH receptor A6. (1125 aa)
ILKIntegrin linked kinase. (452 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (772 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (792 aa)
SRGAP1SLIT-ROBO Rho GTPase activating protein 1. (1085 aa)
LOC100052122Uncharacterized protein. (461 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
PLCG2Phosphoinositide phospholipase C. (1331 aa)
PPP3CCSerine/threonine-protein phosphatase. (534 aa)
NFATC3Nuclear factor of activated T cells 3. (1073 aa)
LIMK2LIM domain kinase 2. (652 aa)
TRPC4Transient receptor potential cation channel subfamily C member 4; Belongs to the transient receptor (TC 1.A.4) family. (982 aa)
EFNA2Ephrin A2; Belongs to the ephrin family. (214 aa)
EPHB6EPH receptor B6. (1011 aa)
RAC1Rac family small GTPase 1. (221 aa)
PPP3CASerine/threonine-protein phosphatase. (717 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
RAC2Rac family small GTPase 2. (192 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (591 aa)
RHOATransforming protein RhoA-like protein. (193 aa)
PDK1Protein-serine/threonine kinase. (438 aa)
RYKReceptor like tyrosine kinase. (611 aa)
PARD6BPar-6 family cell polarity regulator beta. (391 aa)
DPYSL5Dihydropyrimidinase like 5. (661 aa)
SEMA6BSemaphorin 6B; Belongs to the semaphorin family. (993 aa)
LIMK1LIM domain kinase 1. (789 aa)
BMP7Bone morphogenetic protein 7. (437 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (582 aa)
SLIT2Slit guidance ligand 2. (1543 aa)
PLXNB1Plexin B1. (2140 aa)
PLXNB2Plexin B2. (2217 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1047 aa)
L1CAML1 cell adhesion molecule. (1257 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (656 aa)
SEMA5ASemaphorin 5A. (1079 aa)
ROBO2Roundabout guidance receptor 2. (1479 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (920 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (556 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (808 aa)
UNC5BUnc-5 netrin receptor B. (976 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (770 aa)
SEMA5BSemaphorin 5B. (1140 aa)
EPHB2EPH receptor B2. (1018 aa)
ROBO1Roundabout guidance receptor 1. (1651 aa)
SRGAP3SLIT-ROBO Rho GTPase activating protein 3. (1104 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
MYL12AMyosin light chain 12A. (178 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
DCCDCC netrin 1 receptor. (1447 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (966 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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