STRINGSTRING
MAPK11 MAPK11 PLA2G4D PLA2G4D SPHK2 SPHK2 PIK3CD PIK3CD HRAS HRAS AKT2 AKT2 PPP3CB PPP3CB VEGFA VEGFA SHC2 SHC2 MAP2K2 MAP2K2 MAP2K1 MAP2K1 SRC SRC PLA2G4F PLA2G4F NRAS NRAS MAPK3 MAPK3 MAPK14 MAPK14 BAD BAD PIK3CA PIK3CA PTGS2 PTGS2 MAPK12 MAPK12 NFATC2 NFATC2 KRAS KRAS PRKCG PRKCG AKT3 AKT3 KDR KDR PIK3R1 PIK3R1 HSPB1 HSPB1 PLCG1 PLCG1 MAPKAPK2 MAPKAPK2 PIK3CB PIK3CB NOS3 NOS3 PIK3R2 PIK3R2 CDC42 CDC42 PTK2 PTK2 WDR92 WDR92 PLA2G4A PLA2G4A LOC100052122 LOC100052122 PLCG2 PLCG2 PPP3CC PPP3CC PLA2G4E PLA2G4E AKT1 AKT1 RAC1 RAC1 PPP3CA PPP3CA PRKCA PRKCA RAC2 RAC2 CASP9 CASP9 MAPK13 MAPK13 JMJD7 JMJD7 PRKCB PRKCB SPHK1 SPHK1 MAPKAPK3 MAPKAPK3 PXN PXN SH2D2A SH2D2A MAPK1 MAPK1 RAF1 RAF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK11Mitogen-activated protein kinase. (364 aa)
PLA2G4DPhospholipase A2. (817 aa)
SPHK2Sphingosine kinase 2. (654 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
AKT2Non-specific serine/threonine protein kinase. (528 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
VEGFAVascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (448 aa)
SHC2SHC adaptor protein 2. (579 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SRCTyrosine-protein kinase. (551 aa)
PLA2G4FPhospholipase A2. (849 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
BADBCL2 associated agonist of cell death. (167 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PTGS2Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (666 aa)
MAPK12Mitogen-activated protein kinase. (365 aa)
NFATC2Nuclear factor of activated T cells 2. (915 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1358 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (209 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1267 aa)
PIK3R2Uncharacterized protein. (479 aa)
CDC42Cell division control protein 42-like protein. (191 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1093 aa)
WDR92Protein phosphatase 3 regulatory subunit B, alpha. (496 aa)
PLA2G4ACytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. (749 aa)
LOC100052122Uncharacterized protein. (461 aa)
PLCG2Phosphoinositide phospholipase C. (1331 aa)
PPP3CCSerine/threonine-protein phosphatase. (534 aa)
PLA2G4EPhospholipase A2. (864 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
RAC1Rac family small GTPase 1. (221 aa)
PPP3CASerine/threonine-protein phosphatase. (717 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
RAC2Rac family small GTPase 2. (192 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (632 aa)
MAPK13Mitogen-activated protein kinase. (421 aa)
JMJD7Phospholipase A2. (849 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
SPHK1Sphingosine kinase 1. (459 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (403 aa)
PXNPaxillin. (1236 aa)
SH2D2ASH2 domain containing 2A. (456 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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