(58 nodes) Adherens junction network (Equus caballus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	WASF3	WASP family member 3. (502 aa)
	CTNNB1	Beta catenin 1. (781 aa)
	CTNNA3	Catenin alpha 3. (895 aa)
	FARP2	FERM, ARH/RhoGEF and pleckstrin domain protein 2. (1057 aa)
	SNAI1	Snail family transcriptional repressor 1. (265 aa)
	EP300	E1A binding protein p300. (2430 aa)
	INSR	Tyrosine-protein kinase receptor. (1382 aa)
	ACP1	Acid phosphatase 1. (158 aa)
	SNAI2	Snail family transcriptional repressor 2. (268 aa)
	NLK	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
	MET	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1412 aa)
	SRC	Tyrosine-protein kinase. (551 aa)
	CSNK2A2	Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (350 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (687 aa)
	WASL	WASP like actin nucleation promoting factor. (505 aa)
	ACTB	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (377 aa)
	PARD3	Par-3 family cell polarity regulator. (1360 aa)
	CSNK2B	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (235 aa)
	CDH1	Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (900 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1367 aa)
	YES1	Tyrosine-protein kinase. (583 aa)
	WASF1	WASP family member 1. (572 aa)
	CTNNA1	Catenin alpha 1. (944 aa)
	CREBBP	CREB binding protein. (2442 aa)
	PTPRB	Protein tyrosine phosphatase receptor type B. (2245 aa)
	PTPN1	Protein tyrosine phosphatase non-receptor type 1. (493 aa)
	TCF7L2	Transcription factor 7 like 2. (669 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	CDC42	Cell division control protein 42-like protein. (191 aa)
	PTPRM	Protein tyrosine phosphatase receptor type M. (1507 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1255 aa)
	NECTIN4	Nectin cell adhesion molecule 4. (509 aa)
	LPAR3	SSX family member 2 interacting protein; Belongs to the G-protein coupled receptor 1 family. (870 aa)
	NECTIN1	Nectin cell adhesion molecule 1. (782 aa)
	TJP1	Tight junction protein 1; Belongs to the MAGUK family. (1880 aa)
	TCF7L1	Transcription factor 7 like 1. (758 aa)
	EGFR	Receptor protein-tyrosine kinase. (1195 aa)
	RAC1	Rac family small GTPase 1. (221 aa)
	RAC2	Rac family small GTPase 2. (192 aa)
	RHOA	Transforming protein RhoA-like protein. (193 aa)
	PTPRF	Protein tyrosine phosphatase receptor type F. (1923 aa)
	LEF1	Lymphoid enhancer binding factor 1. (413 aa)
	NECTIN3	Nectin cell adhesion molecule 3. (549 aa)
	ACTN1	Actinin alpha 1. (959 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	IQGAP1	IQ motif containing GTPase activating protein 1. (2101 aa)
	ACTN4	Actinin alpha 4. (933 aa)
	LOC111775907	Uncharacterized protein. (1211 aa)
	CSNK2A1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (464 aa)
	BAIAP2	BAI1 associated protein 2. (670 aa)
	CTNND1	Catenin delta 1. (967 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
	FGFR1	Fibroblast growth factor receptor. (877 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa)
	CTNNA2	Catenin alpha 2. (953 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
	FER	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (836 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACP1	CTNNB1	ENSECAP00000008037	ENSECAP00000005466	Acid phosphatase 1.	Beta catenin 1.	0.939
ACTB	ACTN1	ENSECAP00000013637	ENSECAP00000039117	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Actinin alpha 1.	0.946
ACTB	ACTN4	ENSECAP00000013637	ENSECAP00000043230	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Actinin alpha 4.	0.939
ACTB	BAIAP2	ENSECAP00000013637	ENSECAP00000044887	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	BAI1 associated protein 2.	0.930
ACTB	CDC42	ENSECAP00000013637	ENSECAP00000025414	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Cell division control protein 42-like protein.	0.963
ACTB	CDH1	ENSECAP00000013637	ENSECAP00000019251	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins.	0.425
ACTB	CREBBP	ENSECAP00000013637	ENSECAP00000022419	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	CREB binding protein.	0.452
ACTB	CTNNA1	ENSECAP00000013637	ENSECAP00000021721	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Catenin alpha 1.	0.926
ACTB	CTNNA2	ENSECAP00000013637	ENSECAP00000050260	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Catenin alpha 2.	0.924
ACTB	CTNNA3	ENSECAP00000013637	ENSECAP00000006233	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Catenin alpha 3.	0.924
ACTB	CTNNB1	ENSECAP00000013637	ENSECAP00000005466	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Beta catenin 1.	0.512
ACTB	EGFR	ENSECAP00000013637	ENSECAP00000035347	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Receptor protein-tyrosine kinase.	0.729
ACTB	EP300	ENSECAP00000013637	ENSECAP00000007916	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	E1A binding protein p300.	0.428
ACTB	ERBB2	ENSECAP00000013637	ENSECAP00000027916	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Receptor protein-tyrosine kinase.	0.493
ACTB	FGFR1	ENSECAP00000013637	ENSECAP00000047204	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Fibroblast growth factor receptor.	0.426
ACTB	IGF1R	ENSECAP00000013637	ENSECAP00000019400	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Tyrosine-protein kinase receptor.	0.523
ACTB	INSR	ENSECAP00000013637	ENSECAP00000008032	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Tyrosine-protein kinase receptor.	0.420
ACTB	IQGAP1	ENSECAP00000013637	ENSECAP00000039842	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	IQ motif containing GTPase activating protein 1.	0.944
ACTB	RAC1	ENSECAP00000013637	ENSECAP00000035360	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Rac family small GTPase 1.	0.407
ACTB	RHOA	ENSECAP00000013637	ENSECAP00000036784	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Transforming protein RhoA-like protein.	0.973