STRINGSTRING
FZD10 FZD10 ISL1 ISL1 DVL2 DVL2 HAND1 HAND1 WNT2B WNT2B MAPK11 MAPK11 WNT16 WNT16 CTNNB1 CTNNB1 HESX1 HESX1 PIK3CD PIK3CD PCGF2 PCGF2 HRAS HRAS ID2 ID2 AKT2 AKT2 WNT5A WNT5A POU5F1 POU5F1 WNT1 WNT1 DVL3 DVL3 MAP2K2 MAP2K2 MEIS1 MEIS1 KAT6A KAT6A JAK2 JAK2 PCGF3 PCGF3 KLF4 KLF4 SKIL SKIL SOX2 SOX2 INHBC INHBC MAP2K1 MAP2K1 INHBE INHBE PCGF1 PCGF1 HOXB1 HOXB1 SMARCAD1 SMARCAD1 NANOG NANOG SMAD9 SMAD9 WNT6 WNT6 ID4 ID4 ZIC3 ZIC3 WNT7B WNT7B NRAS NRAS INHBB INHBB FGF2 FGF2 MAPK3 MAPK3 FZD6 FZD6 WNT8A WNT8A MAPK14 MAPK14 PIK3CA PIK3CA PCGF5 PCGF5 WNT5B WNT5B LHX5 LHX5 NODAL NODAL PCGF6 PCGF6 FZD2 FZD2 BMP4 BMP4 MAPK12 MAPK12 AXIN2 AXIN2 FZD3 FZD3 SMAD5 SMAD5 WNT4 WNT4 ACVR1 ACVR1 JAK1 JAK1 LOC102148742 LOC102148742 KRAS KRAS DLX5 DLX5 AKT3 AKT3 ACVR1C ACVR1C MYF5 MYF5 PIK3R1 PIK3R1 LIFR LIFR BMPR1A BMPR1A DVL1 DVL1 PAX6 PAX6 HOXA1 HOXA1 WNT3 WNT3 IGF1R IGF1R MYC MYC WNT11 WNT11 INHBA INHBA REST REST SMAD1 SMAD1 ZFHX3 ZFHX3 ID3 ID3 AXIN1 AXIN1 PIK3CB PIK3CB WNT2 WNT2 GSK3B GSK3B BMPR2 BMPR2 PIK3R2 PIK3R2 WNT3A WNT3A WNT10A WNT10A SMAD4 SMAD4 IL6ST IL6ST FZD5 FZD5 LIF LIF LOC106781385 LOC106781385 WNT8B WNT8B WNT7A WNT7A RIF1 RIF1 SMAD2 SMAD2 LOC100052122 LOC100052122 APC2 APC2 HOXD1 HOXD1 SETDB1 SETDB1 WNT10B WNT10B IGF1 IGF1 AKT1 AKT1 NEUROG1 NEUROG1 STAT3 STAT3 TCF3 TCF3 LOC100054366 LOC100054366 APC APC WNT9B WNT9B WNT9A WNT9A ESRRB ESRRB SMAD3 SMAD3 ACVR2A ACVR2A LOC100062658 LOC100062658 DUSP9 DUSP9 MAPK13 MAPK13 ID1 ID1 LOC100147245 LOC100147245 JAK3 JAK3 JARID2 JARID2 FZD7 FZD7 FZD4 FZD4 OTX1 OTX1 FGFR1 FGFR1 MAPK1 MAPK1 FGFR2 FGFR2 ACVR2B ACVR2B FGFR4 FGFR4 TBX3 TBX3 RAF1 RAF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
ISL1ISL LIM homeobox 1. (349 aa)
DVL2Dishevelled segment polarity protein 2. (737 aa)
HAND1Heart and neural crest derivatives expressed 1. (218 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (495 aa)
CTNNB1Beta catenin 1. (781 aa)
HESX1HESX homeobox 1. (185 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
AKT2Non-specific serine/threonine protein kinase. (528 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
POU5F1POU domain protein. (360 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
DVL3Dishevelled segment polarity protein 3. (716 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
MEIS1Meis homeobox 1. (465 aa)
KAT6AHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2009 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
PCGF3Polycomb group ring finger 3. (242 aa)
KLF4Kruppel like factor 4. (485 aa)
SKILSKI like proto-oncogene. (683 aa)
SOX2SRY-box transcription factor 2. (321 aa)
INHBCInhibin subunit beta C. (351 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
INHBEInhibin subunit beta E. (351 aa)
PCGF1Polycomb group ring finger 1. (259 aa)
HOXB1Homeobox B1. (301 aa)
SMARCAD1Uncharacterized protein. (1029 aa)
NANOGHomeobox domain-containing protein. (310 aa)
SMAD9Mothers against decapentaplegic homolog. (430 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (161 aa)
ZIC3Zic family member 3. (535 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
INHBBInhibin subunit beta B. (928 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PCGF5Polycomb group RING finger protein 5-like protein. (256 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
LHX5LIM homeobox 5. (402 aa)
NODALNodal growth differentiation factor. (348 aa)
PCGF6Polycomb group ring finger 6. (351 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
MAPK12Mitogen-activated protein kinase. (365 aa)
AXIN2Axin 2. (843 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
JAK1Tyrosine-protein kinase. (1141 aa)
LOC102148742RING-type domain-containing protein. (341 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
DLX5Distal-less homeobox 5. (289 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (492 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
LIFRLIF receptor subunit alpha. (1332 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
DVL1Dishevelled segment polarity protein 1. (700 aa)
PAX6Paired box 6. (436 aa)
HOXA1Homeobox A1. (336 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (475 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (442 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
INHBAInhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (426 aa)
RESTRE1 silencing transcription factor. (1039 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
ZFHX3Zinc finger homeobox 3. (3711 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (227 aa)
AXIN1Axin 1. (939 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (440 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
PIK3R2Uncharacterized protein. (479 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
IL6STInterleukin 6 signal transducer. (1023 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (577 aa)
LIFLIF interleukin 6 family cytokine. (203 aa)
LOC106781385Homeobox domain-containing protein. (217 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (379 aa)
RIF1Replication timing regulatory factor 1. (2476 aa)
SMAD2Mothers against decapentaplegic homolog. (610 aa)
LOC100052122Uncharacterized protein. (461 aa)
APC2APC regulator of WNT signaling pathway 2. (2301 aa)
HOXD1Homeobox D1. (321 aa)
SETDB1SET domain bifurcated histone lysine methyltransferase 1. (1299 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
NEUROG1Neurogenin 1. (347 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
TCF3Transcription factor 3. (679 aa)
LOC100054366Left-right determination factor. (367 aa)
APCAPC regulator of WNT signaling pathway. (2873 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
ESRRBEstrogen related receptor beta. (454 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
LOC100062658RING-type domain-containing protein. (256 aa)
DUSP9Dual specificity phosphatase 9. (557 aa)
MAPK13Mitogen-activated protein kinase. (421 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
LOC100147245Left-right determination factor. (367 aa)
JAK3Tyrosine-protein kinase. (1139 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1447 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
OTX1Orthodenticle homeobox 1. (412 aa)
FGFR1Fibroblast growth factor receptor. (877 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa)
FGFR2Fibroblast growth factor receptor. (887 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (577 aa)
FGFR4Fibroblast growth factor receptor. (855 aa)
TBX3T-box transcription factor 3. (745 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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