STRINGSTRING
F13B F13B F11 F11 C3AR1 C3AR1 F2RL3 F2RL3 SERPINB2 SERPINB2 F2R F2R THBD THBD BDKRB2 BDKRB2 BDKRB1 BDKRB1 F7 F7 C5AR1 C5AR1 F5 F5 CLU CLU PLAU PLAU C9 C9 LOC100059239 LOC100059239 C1S C1S F2RL2 F2RL2 FGB FGB F12 F12 SERPING1 SERPING1 F6ZRH8_HORSE F6ZRH8_HORSE CFH CFH F2 F2 LOC100057335 LOC100057335 SERPIND1 SERPIND1 CFI CFI SERPINC1 SERPINC1 F10 F10 VTN VTN MBL2 MBL2 ITGAM ITGAM C5 C5 C1QB C1QB SERPINE1 SERPINE1 F9 F9 C1R C1R MASP2 MASP2 PLAUR PLAUR LOC100066313 LOC100066313 F3 F3 ITGAD ITGAD PROCR PROCR PROC PROC F8 F8 VWF VWF PROS1 PROS1 F13A1 F13A1 VSIG4 VSIG4 PLG PLG SERPINA5 SERPINA5 C8B C8B CFD CFD CD59 CD59 FGA FGA C4BPA C4BPA CD55 CD55 CR2 CR2 C1QC C1QC C7 C7 LOC100057500 LOC100057500 PLAT PLAT CFB CFB ITGB2 ITGB2 C6 C6 LOC100060815 LOC100060815 CPB2 CPB2 KLKB1 KLKB1 FGG FGG TFPI TFPI C8A C8A LOC100060505 LOC100060505 KNG1 KNG1 SERPINF2 SERPINF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
F13BCoagulation factor XIII B chain. (640 aa)
F11Coagulation factor XI; Belongs to the peptidase S1 family. (625 aa)
C3AR1Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family. (484 aa)
F2RL3F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. (394 aa)
SERPINB2Serpin family B member 10; Belongs to the serpin family. (415 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (428 aa)
THBDThrombomodulin. (559 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (414 aa)
BDKRB1Bradykinin receptor B1. (352 aa)
F7Coagulation factor VII. (446 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (374 aa)
F5Coagulation factor V; Belongs to the multicopper oxidase family. (2266 aa)
CLUClusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysos [...] (450 aa)
PLAUPlasminogen activator, urokinase. (433 aa)
C9Complement component C9; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC. (547 aa)
LOC100059239Uncharacterized protein. (1578 aa)
C1SComplement C1s; Belongs to the peptidase S1 family. (689 aa)
F2RL2Coagulation factor II thrombin receptor like 2. (378 aa)
FGBFibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] (495 aa)
F12Coagulation factor XII. (615 aa)
SERPING1Serpin family G member 1; Belongs to the serpin family. (568 aa)
F6ZRH8_HORSEUncharacterized protein. (927 aa)
CFHUncharacterized protein. (1252 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
LOC100057335Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. (380 aa)
SERPIND1Serpin family D member 1; Belongs to the serpin family. (496 aa)
CFIUncharacterized protein; Belongs to the peptidase S1 family. (630 aa)
SERPINC1Serpin family C member 1; Belongs to the serpin family. (465 aa)
F10Coagulation factor X. (491 aa)
VTNVitronectin. (478 aa)
MBL2Mannose binding lectin 2. (255 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1142 aa)
C5Complement C5. (1679 aa)
C1QBComplement C1q B chain. (252 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
F9Coagulation factor IX. (457 aa)
C1RComplement C1r; Belongs to the peptidase S1 family. (705 aa)
MASP2Mannan binding lectin serine peptidase 2; Belongs to the peptidase S1 family. (686 aa)
PLAURPlasminogen activator, urokinase receptor. (334 aa)
LOC100066313C-type lectin domain-containing protein. (249 aa)
F3Coagulation factor III, tissue factor. (388 aa)
ITGADIntegrin subunit alpha X; Belongs to the integrin alpha chain family. (1203 aa)
PROCRProtein C receptor. (241 aa)
PROCVitamin K-dependent protein C; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Belongs to the peptidase S1 family. (640 aa)
F8Coagulation factor VIII; Belongs to the multicopper oxidase family. (2331 aa)
VWFVon Willebrand factor. (2813 aa)
PROS1Protein S. (912 aa)
F13A1Coagulation factor XIII A chain. (746 aa)
VSIG4V-set and immunoglobulin domain containing 4. (445 aa)
PLGPlasmin heavy chain A; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be m [...] (817 aa)
SERPINA5Serpin family A member 5; Belongs to the serpin family. (424 aa)
C8BComplement C8 beta chain. (590 aa)
CFDPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (419 aa)
CD59UPAR/Ly6 domain-containing protein. (127 aa)
FGAFibrinogen alpha chain. (975 aa)
C4BPAUncharacterized protein. (714 aa)
CD55Uncharacterized protein. (411 aa)
CR2Complement C3d receptor 2. (1159 aa)
C1QCComplement C1q C chain. (706 aa)
C7Complement C7. (910 aa)
LOC100057500Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. (384 aa)
PLATPlasminogen activator, tissue type. (615 aa)
CFBUncharacterized protein; Belongs to the peptidase S1 family. (768 aa)
ITGB2Integrin beta. (873 aa)
C6Complement C6. (954 aa)
LOC100060815Uncharacterized protein. (1051 aa)
CPB2Carboxypeptidase B2. (423 aa)
KLKB1Kallikrein B1; Belongs to the peptidase S1 family. (892 aa)
FGGFibrinogen gamma chain. (460 aa)
TFPITissue factor pathway inhibitor. (348 aa)
C8AComplement C8 alpha chain. (589 aa)
LOC100060505Uncharacterized protein. (1662 aa)
KNG1Kininogen 1. (653 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (491 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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