STRINGSTRING
GNAI1 GNAI1 LOC100054420 LOC100054420 GNAI2 GNAI2 P2RY1 P2RY1 GP5 GP5 F2RL3 F2RL3 F2R F2R LOC100050675 LOC100050675 RAP1B RAP1B LOC100049912 LOC100049912 MAPK11 MAPK11 PLA2G4D PLA2G4D PIK3CD PIK3CD VASP VASP FERMT3 FERMT3 MYLK3 MYLK3 AKT2 AKT2 SNAP23 SNAP23 VAMP8 VAMP8 FCER1G FCER1G PTGS1 PTGS1 GNAI3 GNAI3 P2RX1 P2RX1 FGB FGB ADCY5 ADCY5 RASGRP1 RASGRP1 PPP1CA PPP1CA ROCK2 ROCK2 F2 F2 SRC SRC PLCB3 PLCB3 PLA2G4F PLA2G4F ORAI1 ORAI1 ADCY4 ADCY4 MAPK3 MAPK3 MAPK14 MAPK14 PIK3CA PIK3CA ACTB ACTB ADCY2 ADCY2 PPP1CC PPP1CC TBXAS1 TBXAS1 GNA13 GNA13 MAPK12 MAPK12 TLN1 TLN1 GUCY1A2 GUCY1A2 GNAQ GNAQ ITGB3 ITGB3 PIK3CG PIK3CG AKT3 AKT3 PIK3R1 PIK3R1 ITGA2B ITGA2B PLCB1 PLCB1 GUCY1B1 GUCY1B1 BTK BTK ROCK1 ROCK1 TLN2 TLN2 LCP2 LCP2 GP6 GP6 APBB1IP APBB1IP P2RY12 P2RY12 RASGRP2 RASGRP2 PTGIR PTGIR ADCY9 ADCY9 PIK3CB PIK3CB PRKG2 PRKG2 ADCY8 ADCY8 NOS3 NOS3 COL1A2 COL1A2 ADCY1 ADCY1 ITGA2 ITGA2 PIK3R2 PIK3R2 ENSECAP00000024650 ENSECAP00000024650 ITPR2 ITPR2 ARHGEF1 ARHGEF1 PRKCI PRKCI ADCY6 ADCY6 ADCY3 ADCY3 VWF VWF PLA2G4A PLA2G4A PLCB4 PLCB4 PRKACA PRKACA LOC100052122 LOC100052122 GP9 GP9 PLCG2 PLCG2 PLA2G4E PLA2G4E MYLK2 MYLK2 AKT1 AKT1 GUCY1A1 GUCY1A1 GP1BB GP1BB PRKCZ PRKCZ RHOA RHOA MYLK MYLK SYK SYK GP1BA GP1BA ADCY7 ADCY7 FGA FGA ITPR3 ITPR3 PRKACB PRKACB ARHGAP35 ARHGAP35 MAPK13 MAPK13 PRKG1 PRKG1 JMJD7 JMJD7 LYN LYN ARHGEF12 ARHGEF12 MYLK4 MYLK4 TBXA2R TBXA2R ITGB1 ITGB1 MAPK1 MAPK1 PIK3R5 PIK3R5 FGG FGG PLCB2 PLCB2 LOC100051733 LOC100051733 ITPR1 ITPR1 MYL12A MYL12A PPP1R12A PPP1R12A COL1A1 COL1A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GNAI1G protein subunit alpha i1. (354 aa)
LOC100054420Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (662 aa)
GNAI2G protein subunit alpha i2. (355 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (374 aa)
GP5Glycoprotein V platelet. (511 aa)
F2RL3F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. (394 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (428 aa)
LOC100050675Uncharacterized protein. (250 aa)
RAP1BRas-related protein Rap-1b-like protein. (184 aa)
LOC100049912Uncharacterized protein. (184 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
PLA2G4DPhospholipase A2. (817 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (385 aa)
FERMT3Fermitin family member 3. (699 aa)
MYLK3Myosin light chain kinase 3. (809 aa)
AKT2Non-specific serine/threonine protein kinase. (528 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
VAMP8Vesicle associated membrane protein 8. (100 aa)
FCER1GFc fragment of IgE receptor Ig. (86 aa)
PTGS1Prostaglandin-endoperoxide synthase 1. (599 aa)
GNAI3G protein subunit alpha i3. (354 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
FGBFibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] (495 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
RASGRP1RAS guanyl releasing protein 1. (797 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1468 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
SRCTyrosine-protein kinase. (551 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
PLA2G4FPhospholipase A2. (849 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (313 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (377 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
TBXAS1Thromboxane A synthase 1; Belongs to the cytochrome P450 family. (534 aa)
GNA13G protein subunit alpha 13. (377 aa)
MAPK12Mitogen-activated protein kinase. (365 aa)
TLN1Talin 1. (2558 aa)
GUCY1A2Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (727 aa)
GNAQG protein subunit alpha q. (441 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1108 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (619 aa)
BTKTyrosine-protein kinase. (687 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
TLN2Talin 2. (2572 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
GP6Glycoprotein VI platelet. (335 aa)
APBB1IPAmyloid beta precursor protein binding family B member 1 interacting protein. (686 aa)
P2RY12Purinergic receptor P2Y12. (342 aa)
RASGRP2RAS guanyl releasing protein 2. (608 aa)
PTGIRProstaglandin I2 receptor; Belongs to the G-protein coupled receptor 1 family. (384 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PRKG2cGMP-dependent protein kinase. (762 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1267 aa)
COL1A2Collagen type I alpha 2 chain. (1364 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1124 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1301 aa)
PIK3R2Uncharacterized protein. (479 aa)
ENSECAP00000024650Uncharacterized protein. (88 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (1040 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (655 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1206 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1200 aa)
VWFVon Willebrand factor. (2813 aa)
PLA2G4ACytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. (749 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1236 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (359 aa)
LOC100052122Uncharacterized protein. (461 aa)
GP9Glycoprotein IX platelet. (177 aa)
PLCG2Phosphoinositide phospholipase C. (1331 aa)
PLA2G4EPhospholipase A2. (864 aa)
MYLK2Myosin light chain kinase 2. (938 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
GP1BBGlycoprotein Ib platelet subunit beta. (208 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (591 aa)
RHOATransforming protein RhoA-like protein. (193 aa)
MYLKMyosin light chain kinase. (2069 aa)
SYKTyrosine-protein kinase. (716 aa)
GP1BAGlycoprotein Ib platelet subunit alpha. (608 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
FGAFibrinogen alpha chain. (975 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
ARHGAP35Rho GTPase activating protein 35. (1553 aa)
MAPK13Mitogen-activated protein kinase. (421 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
JMJD7Phospholipase A2. (849 aa)
LYNTyrosine-protein kinase. (533 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (432 aa)
TBXA2RThromboxane A2 receptor; Belongs to the G-protein coupled receptor 1 family. (343 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (808 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 6. (890 aa)
FGGFibrinogen gamma chain. (460 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1273 aa)
LOC100051733Uncharacterized protein. (635 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
MYL12AMyosin light chain 12A. (178 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1030 aa)
COL1A1Collagen type I alpha 1 chain. (1521 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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