(64 nodes) RIG-I-like receptor signaling pathway network (Equus caballus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ISG15	ISG15 ubiquitin like modifier. (164 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
	IFND2	Uncharacterized protein. (170 aa)
	LOC100053263	Uncharacterized protein. (195 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (464 aa)
	MAPK11	Mitogen-activated protein kinase. (364 aa)
	IFNB1	Interferon beta; Has antiviral, antibacterial and anticancer activities. (186 aa)
	IFN-OMEGA2	Uncharacterized protein. (195 aa)
	LOC100053210	Uncharacterized protein. (184 aa)
	LOC100629859	Uncharacterized protein. (195 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase. (164 aa)
	IFIH1	Interferon induced with helicase C domain 1. (1026 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (671 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (329 aa)
	CXCL10	C-X-C motif chemokine. (104 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
	TRADD	TNFRSF1A associated via death domain. (312 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (551 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	CXCL8	Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity). (101 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (1049 aa)
	TKFC	Triokinase and FMN cyclase. (578 aa)
	TBKBP1	TBK1 binding protein 1. (700 aa)
	MAPK12	Mitogen-activated protein kinase. (365 aa)
	IRF3	Interferon regulatory factor 3. (426 aa)
	NLRX1	NLR family member X1. (975 aa)
	SIKE1	Suppressor of IKBKE 1. (211 aa)
	AZI2	5-azacytidine induced 2. (406 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
	TBK1	TANK binding kinase 1. (729 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (212 aa)
	IFNK	Interferon kappa. (208 aa)
	DDX58	DExD/H-box helicase 58. (1021 aa)
	NFKBIA	NFKB inhibitor alpha. (543 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (478 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (256 aa)
	TANK	TRAF family member associated NFKB activator. (426 aa)
	IKBKE	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (822 aa)
	STING1	Transmembrane protein 173. (405 aa)
	IFN-ALPHA2	Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities. (184 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (770 aa)
	MAP3K1	Mitogen-activated protein kinase kinase kinase 1. (1672 aa)
	MAPK9	Mitogen-activated protein kinase. (446 aa)
	LOC100052971	Uncharacterized protein. (195 aa)
	DHX58	DExH-box helicase 58. (762 aa)
	DDX3X	DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (685 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
	LOC100053110	Interferon alpha-4; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (184 aa)
	MAPK13	Mitogen-activated protein kinase. (421 aa)
	LOC100053069	Interferon omega-2. (195 aa)
	LOC100629951	Interferon alpha-1; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (184 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
	MAVS	Mitochondrial antiviral signaling protein. (597 aa)
	LOC100629885	Uncharacterized protein. (167 aa)
	LOC100064612	Uncharacterized protein. (171 aa)
	NFKBIB	NFKB inhibitor beta. (371 aa)
	MAPK10	Mitogen-activated protein kinase. (467 aa)
	LOC100147174	Uncharacterized protein. (186 aa)
	CYLD	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
	LOC111767428	Interferon omega-1. (195 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG12	ATG5	ENSECAP00000010242	ENSECAP00000011693	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG12	CASP8	ENSECAP00000010242	ENSECAP00000004066	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Caspase 8; Belongs to the peptidase C14A family.	0.478
ATG12	DDX58	ENSECAP00000010242	ENSECAP00000019669	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	DExD/H-box helicase 58.	0.955
ATG12	FADD	ENSECAP00000010242	ENSECAP00000018837	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.584
ATG12	IFIH1	ENSECAP00000010242	ENSECAP00000006532	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Interferon induced with helicase C domain 1.	0.540
ATG12	MAVS	ENSECAP00000010242	ENSECAP00000045434	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Mitochondrial antiviral signaling protein.	0.979
ATG12	NLRX1	ENSECAP00000010242	ENSECAP00000016970	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	NLR family member X1.	0.463
ATG5	ATG12	ENSECAP00000011693	ENSECAP00000010242	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.999
ATG5	CASP10	ENSECAP00000011693	ENSECAP00000021726	Autophagy protein 5; Involved in autophagic vesicle formation.	Caspase 10; Belongs to the peptidase C14A family.	0.447
ATG5	CASP8	ENSECAP00000011693	ENSECAP00000004066	Autophagy protein 5; Involved in autophagic vesicle formation.	Caspase 8; Belongs to the peptidase C14A family.	0.654
ATG5	DDX58	ENSECAP00000011693	ENSECAP00000019669	Autophagy protein 5; Involved in autophagic vesicle formation.	DExD/H-box helicase 58.	0.955
ATG5	FADD	ENSECAP00000011693	ENSECAP00000018837	Autophagy protein 5; Involved in autophagic vesicle formation.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.940
ATG5	IFIH1	ENSECAP00000011693	ENSECAP00000006532	Autophagy protein 5; Involved in autophagic vesicle formation.	Interferon induced with helicase C domain 1.	0.528
ATG5	MAVS	ENSECAP00000011693	ENSECAP00000045434	Autophagy protein 5; Involved in autophagic vesicle formation.	Mitochondrial antiviral signaling protein.	0.980
ATG5	NLRX1	ENSECAP00000011693	ENSECAP00000016970	Autophagy protein 5; Involved in autophagic vesicle formation.	NLR family member X1.	0.471
ATG5	RIPK1	ENSECAP00000011693	ENSECAP00000008268	Autophagy protein 5; Involved in autophagic vesicle formation.	Receptor interacting serine/threonine kinase 1.	0.428
ATG5	TBK1	ENSECAP00000011693	ENSECAP00000018587	Autophagy protein 5; Involved in autophagic vesicle formation.	TANK binding kinase 1.	0.464
ATG5	TNF	ENSECAP00000011693	ENSECAP00000001460	Autophagy protein 5; Involved in autophagic vesicle formation.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.446
AZI2	CHUK	ENSECAP00000017947	ENSECAP00000036997	5-azacytidine induced 2.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.569
AZI2	IKBKB	ENSECAP00000017947	ENSECAP00000030412	5-azacytidine induced 2.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.553