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| | PRL | Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation. (234 aa) |
| | LOC100629870 | Uncharacterized protein. (196 aa) |
| | PTPN2 | Tyrosine-protein phosphatase non-receptor type. (388 aa) |
| | SOCS3 | Suppressor of cytokine signaling 3. (229 aa) |
| | IFND2 | Uncharacterized protein. (170 aa) |
| | SOCS4 | Suppressor of cytokine signaling 4. (441 aa) |
| | LOC100053263 | Uncharacterized protein. (195 aa) |
| | LOC100071430 | Uncharacterized protein. (191 aa) |
| | PIAS2 | Protein inhibitor of activated STAT 2. (621 aa) |
| | IL28B | Uncharacterized protein. (189 aa) |
| | THPO | Thrombopoietin. (350 aa) |
| | IFNB1 | Interferon beta; Has antiviral, antibacterial and anticancer activities. (186 aa) |
| | IFN-OMEGA2 | Uncharacterized protein. (195 aa) |
| | CNTFR | Ciliary neurotrophic factor receptor. (372 aa) |
| | LOC100053210 | Uncharacterized protein. (184 aa) |
| | LOC100629859 | Uncharacterized protein. (195 aa) |
| | IL10RB | Interleukin 10 receptor subunit beta. (386 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | IL20RA | Interleukin 20 receptor subunit alpha. (503 aa) |
| | EPOR | Erythropoietin receptor; Receptor for erythropoietin. (509 aa) |
| | IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (139 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | CSF3 | Colony stimulating factor 3. (204 aa) |
| | IL22RA2 | Interleukin 22 receptor subunit alpha 2. (231 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase. (528 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (249 aa) |
| | STAT6 | Signal transducer and activator of transcription. (847 aa) |
| | GH1 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. (216 aa) |
| | IFNGR1 | Interferon gamma receptor 1. (472 aa) |
| | CSF2 | Granulocyte-macrophage colony-stimulating factor. (152 aa) |
| | PRLR | Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (625 aa) |
| | IL13 | Interleukin-13. (133 aa) |
| | EP300 | E1A binding protein p300. (2430 aa) |
| | JAK2 | Tyrosine-protein kinase. (1131 aa) |
| | IFNAR1 | Interferon alpha and beta receptor subunit 1. (561 aa) |
| | LOC111769802 | Interleukin-7 receptor subunit alpha; Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP) (By similarity); Belongs to the type I cytokine receptor family. Type 4 subfamily. (458 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1209 aa) |
| | IL27RA | Interleukin 27 receptor subunit alpha. (650 aa) |
| | IL24 | Interleukin 24. (206 aa) |
| | CCND2 | Cyclin D2; Belongs to the cyclin family. (289 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (329 aa) |
| | IFNLR1 | Interferon lambda receptor 1. (518 aa) |
| | CSF3R | Colony stimulating factor 3 receptor. (1068 aa) |
| | LEPR | Leptin receptor. (1165 aa) |
| | IL11 | Interleukin 11. (246 aa) |
| | IL10RA | Interleukin 10 receptor subunit alpha. (572 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | IL21 | Interleukin; Belongs to the IL-15/IL-21 family. (158 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (149 aa) |
| | LOC100146423 | Uncharacterized protein. (1343 aa) |
| | IL2RB | Interleukin 2 receptor subunit beta. (558 aa) |
| | IL22RA1 | Interleukin 22 receptor subunit alpha 1. (581 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa) |
| | IL12RB2 | Interleukin 12 receptor subunit beta 2. (906 aa) |
| | IL5 | Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa) |
| | MPL | MPL proto-oncogene, thrombopoietin receptor. (631 aa) |
| | IL23R | Interleukin 23 receptor. (629 aa) |
| | GALT | Galactose-1-phosphate uridylyltransferase; Belongs to the galactose-1-phosphate uridylyltransferase type 1 family. (775 aa) |
| | PIAS3 | Protein inhibitor of activated STAT 3. (629 aa) |
| | MCL1 | MCL1 apoptosis regulator, BCL2 family member. (350 aa) |
| | IL21R | Interleukin 21 receptor. (557 aa) |
| | JAK1 | Tyrosine-protein kinase. (1141 aa) |
| | IL13RA1 | Interleukin 13 receptor subunit alpha 1. (424 aa) |
| | IL22 | Interleukin-22-like protein. (189 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | CSF2RB | Uncharacterized protein. (901 aa) |
| | AOX1 | Uncharacterized protein. (1338 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | LOC100146833 | Uncharacterized protein. (1361 aa) |
| | LIFR | LIF receptor subunit alpha. (1332 aa) |
| | PIM1 | Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa) |
| | IL7 | Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (176 aa) |
| | TYK2 | Tyrosine-protein kinase. (1262 aa) |
| | LOC100065061 | Uncharacterized protein. (191 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (164 aa) |
| | STAM2 | Signal transducing adaptor molecule 2. (525 aa) |
| | IFNK | Interferon kappa. (208 aa) |
| | SOCS7 | Suppressor of cytokine signaling 7. (643 aa) |
| | IL12RB1 | Interleukin 12 receptor subunit beta 1. (718 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (442 aa) |
| | IL23A | Interleukin-23 subunit alpha; Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tu [...] (192 aa) |
| | STAT2 | Signal transducer and activator of transcription. (847 aa) |
| | STAT4 | Signal transducer and activator of transcription. (748 aa) |
| | IL6R | Interleukin 6 receptor. (471 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | IRF9 | Interferon regulatory factor 9. (394 aa) |
| | PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (606 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (256 aa) |
| | PDGFRB | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa) |
| | CREBBP | CREB binding protein. (2442 aa) |
| | IL9R | Interleukin 9 receptor. (499 aa) |
| | SOCS1 | Suppressor of cytokine signaling 1. (222 aa) |
| | IL9 | Interleukin 9. (147 aa) |
| | PIK3R2 | Uncharacterized protein. (479 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (536 aa) |
| | PDGFB | Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (249 aa) |
| | GHR | Growth hormone receptor. (646 aa) |
| | IL15 | Interleukin; Belongs to the IL-15/IL-21 family. (432 aa) |
| | IL6ST | Interleukin 6 signal transducer. (1023 aa) |
| | IFN-ALPHA2 | Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities. (184 aa) |
| | BCL2L1 | BCL2 like 1. (245 aa) |
| | LIF | LIF interleukin 6 family cytokine. (203 aa) |
| | TSLP | Thymic stromal lymphopoetin. (143 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | OSMR | Oncostatin M receptor. (972 aa) |
| | LOC100147106 | Uncharacterized protein. (195 aa) |
| | STAM | Signal transducing adaptor molecule. (727 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa) |
| | ENSECAP00000030960 | Uncharacterized protein. (353 aa) |
| | LOC100052122 | Uncharacterized protein. (461 aa) |
| | IL2RA | Interleukin 2 receptor subunit alpha. (275 aa) |
| | STAT1 | Signal transducer and activator of transcription. (749 aa) |
| | SOCS2 | Suppressor of cytokine signaling 2. (270 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa) |
| | PIAS1 | Protein inhibitor of activated STAT 1. (678 aa) |
| | LOC100052971 | Uncharacterized protein. (195 aa) |
| | IL13RA2 | Interleukin 13 receptor subunit alpha 2. (418 aa) |
| | IL20 | Interleukin 20. (248 aa) |
| | STAT5B | Signal transducer and activator of transcription. (825 aa) |
| | LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (189 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1195 aa) |
| | LOC102148014 | Uncharacterized protein. (355 aa) |
| | STAT3 | Signal transducer and activator of transcription. (770 aa) |
| | LOC100053110 | Interferon alpha-4; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (184 aa) |
| | STAT5A | Signal transducer and activator of transcription. (800 aa) |
| | IL5RA | Interleukin 5 receptor subunit alpha. (480 aa) |
| | LOC100053069 | Interferon omega-2. (195 aa) |
| | PDGFA | PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (569 aa) |
| | JAK3 | Tyrosine-protein kinase. (1139 aa) |
| | LOC100629951 | Interferon alpha-1; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (184 aa) |
| | PDGFRA | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa) |
| | CTF1 | Cardiotrophin 1. (457 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) |
| | AOX4 | FAD-binding PCMH-type domain-containing protein. (1322 aa) |
| | LOC100629885 | Uncharacterized protein. (167 aa) |
| | IFNAR2 | Uncharacterized protein. (530 aa) |
| | NCK1 | Interleukin 20 receptor subunit beta. (484 aa) |
| | LOC100064612 | Uncharacterized protein. (171 aa) |
| | CISH | Cytokine inducible SH2 containing protein. (291 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2573 aa) |
| | IL4R | Interleukin-4 receptor subunit alpha; Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity). (831 aa) |
| | LOC100147174 | Uncharacterized protein. (186 aa) |
| | PTPN6 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1613 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | LOC111767428 | Interferon omega-1. (195 aa) |
| | CCND3 | Cyclin D3; Belongs to the cyclin family. (292 aa) |
| | IFNGR2 | Interferon gamma receptor 2. (461 aa) |
