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| | RORC | RAR related orphan receptor C. (596 aa) |
| | RUNX1 | RUNX family transcription factor 1. (537 aa) |
| | CD3G | CD3g molecule. (178 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (364 aa) |
| | DQA-2 | Ig-like domain-containing protein; Belongs to the MHC class II family. (293 aa) |
| | IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (139 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | HSP90AB1 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] (730 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (525 aa) |
| | STAT6 | Signal transducer and activator of transcription. (847 aa) |
| | CD4 | CD4 molecule. (460 aa) |
| | IFNGR1 | Interferon gamma receptor 1. (472 aa) |
| | JAK2 | Tyrosine-protein kinase. (1131 aa) |
| | ZAP70 | Tyrosine-protein kinase. (619 aa) |
| | TGFB1 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | IL27RA | Interleukin 27 receptor subunit alpha. (650 aa) |
| | DRA | MHC class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (254 aa) |
| | AHR | Uncharacterized protein. (842 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (551 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (381 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | TGFBR2 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (687 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (1049 aa) |
| | IL21 | Interleukin; Belongs to the IL-15/IL-21 family. (158 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (149 aa) |
| | IL2RB | Interleukin 2 receptor subunit beta. (558 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa) |
| | IL23R | Interleukin 23 receptor. (629 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (365 aa) |
| | TBX21 | T-box transcription factor 21. (535 aa) |
| | CD3D | CD3d molecule. (165 aa) |
| | NFATC2 | Nuclear factor of activated T cells 2. (915 aa) |
| | IL21R | Interleukin 21 receptor. (557 aa) |
| | JAK1 | Tyrosine-protein kinase. (1141 aa) |
| | IL22 | Interleukin-22-like protein. (189 aa) |
| | NFKBIE | NFKB inhibitor epsilon. (362 aa) |
| | CD247 | CD247 molecule. (167 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa) |
| | TYK2 | Tyrosine-protein kinase. (1262 aa) |
| | HLA-DOB | MHC class II histocompatibility antigen, DO beta chain. (258 aa) |
| | LAT | Linker for activation of T cells. (238 aa) |
| | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa) |
| | LOC100060996 | MHC class II antigen. (263 aa) |
| | IL12RB1 | Interleukin 12 receptor subunit beta 1. (718 aa) |
| | IL23A | Interleukin-23 subunit alpha; Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tu [...] (192 aa) |
| | RXRB | Retinoid X receptor beta. (536 aa) |
| | LCK | Tyrosine-protein kinase. (509 aa) |
| | NFKBIA | NFKB inhibitor alpha. (543 aa) |
| | RARA | Retinoic acid receptor alpha. (462 aa) |
| | JUN | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (340 aa) |
| | IL6R | Interleukin 6 receptor. (471 aa) |
| | RXRG | Retinoid X receptor gamma. (463 aa) |
| | NFATC1 | Nuclear factor of activated T cells 1. (1067 aa) |
| | GATA3 | GATA binding protein 3. (445 aa) |
| | HLA-DOA | Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (262 aa) |
| | DRB | Ig-like domain-containing protein. (275 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | IL1R1 | Interleukin 1 receptor type 1. (578 aa) |
| | IL6ST | Interleukin 6 signal transducer. (1023 aa) |
| | HSP90AA1 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (835 aa) |
| | LOC111767719 | Ig-like domain-containing protein. (187 aa) |
| | LOC111772100 | Ig-like domain-containing protein. (173 aa) |
| | IRF4 | Interferon regulatory factor 4. (606 aa) |
| | WDR92 | Protein phosphatase 3 regulatory subunit B, alpha. (496 aa) |
| | LOC111768185 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa) |
| | SMAD2 | Mothers against decapentaplegic homolog. (610 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (770 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa) |
| | CD3E | CD3e molecule. (246 aa) |
| | IL2RA | Interleukin 2 receptor subunit alpha. (275 aa) |
| | PPP3CC | Serine/threonine-protein phosphatase. (534 aa) |
| | NFATC3 | Nuclear factor of activated T cells 3. (1073 aa) |
| | STAT1 | Signal transducer and activator of transcription. (749 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (446 aa) |
| | PRKCQ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (811 aa) |
| | STAT5B | Signal transducer and activator of transcription. (825 aa) |
| | FOXP3 | Forkhead box P3. (452 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (717 aa) |
| | STAT3 | Signal transducer and activator of transcription. (770 aa) |
| | DQB | Ig-like domain-containing protein. (309 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | DRB-2 | Ig-like domain-containing protein. (288 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (425 aa) |
| | STAT5A | Signal transducer and activator of transcription. (800 aa) |
| | IL17A | Uncharacterized protein. (155 aa) |
| | RXRA | Retinoid X receptor alpha. (677 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (421 aa) |
| | LOC106783094 | Ig-like domain-containing protein. (229 aa) |
| | JAK3 | Tyrosine-protein kinase. (1139 aa) |
| | IL17F | Interleukin 17F. (154 aa) |
| | LOC100147208 | IRF tryptophan pentad repeat domain-containing protein. (431 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa) |
| | RORA | RAR related orphan receptor A. (527 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa) |
| | HIF1A | Hypoxia inducible factor 1 subunit alpha. (844 aa) |
| | NFKBIB | NFKB inhibitor beta. (371 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2573 aa) |
| | IL4R | Interleukin-4 receptor subunit alpha; Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity). (831 aa) |
| | HLA-DMA | Major histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (314 aa) |
| | DRB-3 | MHC class II antigen. (266 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (268 aa) |
| | IFNGR2 | Interferon gamma receptor 2. (461 aa) |
