STRINGSTRING
CD8B CD8B TNF TNF CTLA4 CTLA4 CD3G CD3G MAPK11 MAPK11 ICOS ICOS CARD11 CARD11 PIK3CD PIK3CD IL4 IL4 HRAS HRAS MAPK8 MAPK8 AKT2 AKT2 PPP3CB PPP3CB IL10 IL10 CD4 CD4 MAP2K7 MAP2K7 CSF2 CSF2 MAP2K2 MAP2K2 RASGRP1 RASGRP1 MAP2K1 MAP2K1 ZAP70 ZAP70 CD8A CD8A MALT1 MALT1 NRAS NRAS RELA RELA FOS FOS MAPK3 MAPK3 MAPK14 MAPK14 MAP3K14 MAP3K14 PIK3CA PIK3CA NFKB1 NFKB1 VAV1 VAV1 IL2 IL2 IL5 IL5 PAK6 PAK6 MAPK12 MAPK12 CD3D CD3D PAK1 PAK1 NFATC2 NFATC2 KRAS KRAS GRAP2 GRAP2 NFKBIE NFKBIE AKT3 AKT3 CD247 CD247 PIK3R1 PIK3R1 PAK2 PAK2 IKBKG IKBKG LAT LAT PLCG1 PLCG1 LCP2 LCP2 LCK LCK NFKBIA NFKBIA JUN JUN PIK3CB PIK3CB GSK3B GSK3B BCL10 BCL10 CDK4 CDK4 PIK3R2 PIK3R2 NFATC1 NFATC1 CDC42 CDC42 LOC111767719 LOC111767719 PAK5 PAK5 LOC111772100 LOC111772100 WDR92 WDR92 NCK2 NCK2 CBLB CBLB IKBKB IKBKB IFNG IFNG LOC100052122 LOC100052122 CD3E CD3E PPP3CC PPP3CC NFATC3 NFATC3 AKT1 AKT1 ITK ITK MAPK9 MAPK9 PRKCQ PRKCQ PPP3CA PPP3CA DLG1 DLG1 RHOA RHOA CHUK CHUK PTPRC PTPRC MAPK13 MAPK13 LOC106783094 LOC106783094 MAP3K8 MAP3K8 PDPK1 PDPK1 VAV3 VAV3 SOS2 SOS2 CD28 CD28 MAPK1 MAPK1 NFKBIB NFKBIB MAPK10 MAPK10 CD40LG CD40LG TEC TEC PTPN6 PTPN6 SOS1 SOS1 RAF1 RAF1 VAV2 VAV2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD8BIg-like domain-containing protein. (221 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
CD3GCD3g molecule. (178 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
ICOSInducible T cell costimulator. (257 aa)
CARD11Caspase recruitment domain family member 11. (1156 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (139 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
AKT2Non-specific serine/threonine protein kinase. (528 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (249 aa)
CD4CD4 molecule. (460 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (494 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (152 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
RASGRP1RAS guanyl releasing protein 1. (797 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
CD8ACD8a molecule. (244 aa)
MALT1MALT1 paracaspase. (850 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (955 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NFKB1Nuclear factor kappa B subunit 1. (1049 aa)
VAV1Vav guanine nucleotide exchange factor 1. (918 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (149 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
PAK6Non-specific serine/threonine protein kinase. (680 aa)
MAPK12Mitogen-activated protein kinase. (365 aa)
CD3DCD3d molecule. (165 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
NFATC2Nuclear factor of activated T cells 2. (915 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
GRAP2GRB2 related adaptor protein 2. (316 aa)
NFKBIENFKB inhibitor epsilon. (362 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CD247CD247 molecule. (167 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
LATLinker for activation of T cells. (238 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
LCKTyrosine-protein kinase. (509 aa)
NFKBIANFKB inhibitor alpha. (543 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (340 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (440 aa)
BCL10BCL10 immune signaling adaptor. (374 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
PIK3R2Uncharacterized protein. (479 aa)
NFATC1Nuclear factor of activated T cells 1. (1067 aa)
CDC42Cell division control protein 42-like protein. (191 aa)
LOC111767719Ig-like domain-containing protein. (187 aa)
PAK5Non-specific serine/threonine protein kinase. (718 aa)
LOC111772100Ig-like domain-containing protein. (173 aa)
WDR92Protein phosphatase 3 regulatory subunit B, alpha. (496 aa)
NCK2Cytoplasmic protein. (380 aa)
CBLBCbl proto-oncogene B. (1189 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (770 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
LOC100052122Uncharacterized protein. (461 aa)
CD3ECD3e molecule. (246 aa)
PPP3CCSerine/threonine-protein phosphatase. (534 aa)
NFATC3Nuclear factor of activated T cells 3. (1073 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
ITKTyrosine-protein kinase. (620 aa)
MAPK9Mitogen-activated protein kinase. (446 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (811 aa)
PPP3CASerine/threonine-protein phosphatase. (717 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (938 aa)
RHOATransforming protein RhoA-like protein. (193 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1399 aa)
MAPK13Mitogen-activated protein kinase. (421 aa)
LOC106783094Ig-like domain-containing protein. (229 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (585 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
CD28CD28 molecule. (228 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa)
NFKBIBNFKB inhibitor beta. (371 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
TECTyrosine-protein kinase. (643 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1613 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
VAV2Vav guanine nucleotide exchange factor 2. (879 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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