STRINGSTRING
CCR9 CCR9 CXCR4 CXCR4 ICOS ICOS DQA-2 DQA-2 IL4 IL4 CCL28 CCL28 ICOSLG ICOSLG IL10 IL10 ITGA4 ITGA4 TGFB1 TGFB1 DRA DRA ITGB7 ITGB7 MAP3K14 MAP3K14 IL2 IL2 PIGR PIGR IL6 IL6 IL5 IL5 CD40 CD40 AICDA AICDA TNFSF13B TNFSF13B CCL25 CCL25 TNFRSF17 TNFRSF17 HLA-DOB HLA-DOB TNFRSF13B TNFRSF13B LOC100060996 LOC100060996 CCR10 CCR10 HLA-DOA HLA-DOA DRB DRB IL15 IL15 ENSECAP00000026008 ENSECAP00000026008 LOC111767719 LOC111767719 LOC111772100 LOC111772100 CD80 CD80 MADCAM1 MADCAM1 DQB DQB LTBR LTBR DRB-2 DRB-2 TNFRSF13C TNFRSF13C CD86 CD86 LOC106783094 LOC106783094 TNFSF12 TNFSF12 CD28 CD28 CD40LG CD40LG HLA-DMA HLA-DMA DRB-3 DRB-3 CXCL12 CXCL12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCR9C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (369 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
ICOSInducible T cell costimulator. (257 aa)
DQA-2Ig-like domain-containing protein; Belongs to the MHC class II family. (293 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (139 aa)
CCL28C-C motif chemokine. (129 aa)
ICOSLGUncharacterized protein. (289 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (249 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1033 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
DRAMHC class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (254 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (798 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (955 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (149 aa)
PIGRPolymeric immunoglobulin receptor. (862 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
CD40Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (280 aa)
AICDAActivation induced cytidine deaminase. (198 aa)
TNFSF13BTumor necrosis factor superfamily member 13b; Belongs to the tumor necrosis factor family. (290 aa)
CCL25C-C motif chemokine ligand 25. (151 aa)
TNFRSF17TNF receptor superfamily member 17. (181 aa)
HLA-DOBMHC class II histocompatibility antigen, DO beta chain. (258 aa)
TNFRSF13BTNF receptor superfamily member 13B. (293 aa)
LOC100060996MHC class II antigen. (263 aa)
CCR10C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family. (363 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (262 aa)
DRBIg-like domain-containing protein. (275 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (432 aa)
ENSECAP00000026008Ig-like domain-containing protein. (182 aa)
LOC111767719Ig-like domain-containing protein. (187 aa)
LOC111772100Ig-like domain-containing protein. (173 aa)
CD80CD80 molecule. (305 aa)
MADCAM1Adhes-Ig_like domain-containing protein. (337 aa)
DQBIg-like domain-containing protein. (309 aa)
LTBRLymphotoxin beta receptor. (434 aa)
DRB-2Ig-like domain-containing protein. (288 aa)
TNFRSF13CB cell-activating factor receptor. (183 aa)
CD86CD86 molecule. (335 aa)
LOC106783094Ig-like domain-containing protein. (229 aa)
TNFSF12Uncharacterized protein; Belongs to the tumor necrosis factor family. (432 aa)
CD28CD28 molecule. (228 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (314 aa)
DRB-3MHC class II antigen. (266 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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