STRINGSTRING
CHRNA6 CHRNA6 CREB3 CREB3 GNAI1 GNAI1 GNAI2 GNAI2 KCNJ3 KCNJ3 CHRM5 CHRM5 KCNJ12 KCNJ12 KCNJ6 KCNJ6 GNG10 GNG10 CHRM1 CHRM1 SLC5A7 SLC5A7 ATF4 ATF4 PIK3CD PIK3CD CREB3L2 CREB3L2 KCNJ2 KCNJ2 GNB4 GNB4 HRAS HRAS GNG14 GNG14 AKT2 AKT2 KCNJ14 KCNJ14 GNAI3 GNAI3 JAK2 JAK2 CHRM3 CHRM3 ADCY5 ADCY5 MAP2K1 MAP2K1 GNG3 GNG3 GNB3 GNB3 PLCB3 PLCB3 ADCY4 ADCY4 NRAS NRAS FOS FOS MAPK3 MAPK3 PIK3CA PIK3CA GNGT2 GNGT2 CHRNB2 CHRNB2 CAMK4 CAMK4 ADCY2 ADCY2 GNB2 GNB2 CACNA1F CACNA1F CREB3L4 CREB3L4 CACNA1D CACNA1D GNG13 GNG13 GNAQ GNAQ KRAS KRAS PRKCG PRKCG PIK3CG PIK3CG AKT3 AKT3 CACNA1S CACNA1S CAMK2A CAMK2A PIK3R1 PIK3R1 KCNQ2 KCNQ2 PLCB1 PLCB1 CHAT CHAT CACNA1C CACNA1C KCNJ4 KCNJ4 GNG11 GNG11 ADCY9 ADCY9 PIK3CB PIK3CB CAMK2D CAMK2D ADCY8 ADCY8 GNG8 GNG8 ADCY1 ADCY1 KCNQ1 KCNQ1 PIK3R2 PIK3R2 LOC100060521 LOC100060521 KCNQ5 KCNQ5 ITPR2 ITPR2 GNG4 GNG4 ADCY6 ADCY6 CACNA1B CACNA1B CREB3L1 CREB3L1 GNGT1 GNGT1 ADCY3 ADCY3 KCNQ4 KCNQ4 PLCB4 PLCB4 PRKACA PRKACA LOC100052122 LOC100052122 GNG5 GNG5 GNG7 GNG7 CACNA1A CACNA1A KCNQ3 KCNQ3 AKT1 AKT1 GNA11 GNA11 PRKCA PRKCA ADCY7 ADCY7 CHRM2 CHRM2 ITPR3 ITPR3 PRKACB PRKACB GNAO1 GNAO1 CHRM4 CHRM4 ACHE ACHE PRKCB PRKCB SLC18A3 SLC18A3 CAMK2B CAMK2B GNB1 GNB1 GNG12 GNG12 CHRNB4 CHRNB4 CHRNA3 CHRNA3 CAMK2G CAMK2G MAPK1 MAPK1 PIK3R5 PIK3R5 CREB3L3 CREB3L3 GNB5 GNB5 CREB5 CREB5 GNG2 GNG2 PLCB2 PLCB2 ITPR1 ITPR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHRNA6Cholinergic receptor nicotinic alpha 6 subunit. (493 aa)
CREB3cAMP responsive element binding protein 3. (390 aa)
GNAI1G protein subunit alpha i1. (354 aa)
GNAI2G protein subunit alpha i2. (355 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
CHRM5Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (532 aa)
KCNJ12Potassium voltage-gated channel subfamily J member 12. (429 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (425 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
SLC5A7Solute carrier family 5 member 7; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (579 aa)
ATF4Activating transcription factor 4. (334 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
KCNJ2Potassium voltage-gated channel subfamily J member 2. (427 aa)
GNB4G protein subunit beta 4. (340 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
GNG14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
AKT2Non-specific serine/threonine protein kinase. (528 aa)
KCNJ14Potassium voltage-gated channel subfamily J member 14. (432 aa)
GNAI3G protein subunit alpha i3. (354 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (603 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GNB3G protein subunit beta 3. (340 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (86 aa)
CHRNB2Cholinergic receptor nicotinic beta 2 subunit. (504 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
GNB2G protein subunit beta 2. (340 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1974 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (393 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2209 aa)
GNG13G protein subunit gamma 13. (67 aa)
GNAQG protein subunit alpha q. (441 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1765 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha. (563 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
KCNQ2Potassium voltage-gated channel subfamily Q member 2; Belongs to the potassium channel family. (872 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
CHATCholine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (641 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2184 aa)
KCNJ4Potassium voltage-gated channel subfamily J member 4. (444 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (543 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1124 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (778 aa)
PIK3R2Uncharacterized protein. (479 aa)
LOC100060521Uncharacterized protein. (510 aa)
KCNQ5Potassium voltage-gated channel subfamily Q member 5. (948 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (164 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1206 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2301 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (524 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1200 aa)
KCNQ4Potassium voltage-gated channel subfamily Q member 4; Belongs to the potassium channel family. (694 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1236 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (359 aa)
LOC100052122Uncharacterized protein. (461 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (341 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2479 aa)
KCNQ3Potassium voltage-gated channel subfamily Q member 3; Belongs to the potassium channel family. (870 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
GNA11G protein subunit alpha 11. (528 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (496 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
GNAO1G protein subunit alpha o1. (354 aa)
CHRM4Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (478 aa)
ACHEAcetylcholinesterase (Cartwright blood group); Belongs to the type-B carboxylesterase/lipase family. (800 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
SLC18A3Solute carrier family 18 member A3. (528 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (656 aa)
GNB1G protein subunit beta 1. (360 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
CHRNB4Cholinergic receptor nicotinic beta 4 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (530 aa)
CHRNA3Cholinergic receptor nicotinic alpha 3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (545 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (556 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 6. (890 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (468 aa)
GNB5G protein subunit beta 5. (395 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (108 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1273 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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