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CREB3 CREB3 LOC100050675 LOC100050675 CANX CANX ATF4 ATF4 GPX6 GPX6 CREB3L2 CREB3L2 ATP1B2 ATP1B2 PDIA4 PDIA4 GPX5 GPX5 PAX8 PAX8 ADCY5 ADCY5 SERPINA7 SERPINA7 PLCB3 PLCB3 TTF2 TTF2 TSHB TSHB ADCY4 ADCY4 ATP1B4 ATP1B4 GSR GSR DUOXA2 DUOXA2 TSHR TSHR TTR TTR ADCY2 ADCY2 CREB3L4 CREB3L4 ATP1B1 ATP1B1 DUOX2 DUOX2 GNAQ GNAQ IYD IYD SLC5A5 SLC5A5 PRKCG PRKCG ATP1B3 ATP1B3 GPX7 GPX7 PLCB1 PLCB1 ATF6B ATF6B GPX8 GPX8 SLC26A4 SLC26A4 ASGR2 ASGR2 ASGR1 ASGR1 HSPA5 HSPA5 DUOX1 DUOX1 ADCY9 ADCY9 ATP1A4 ATP1A4 ADCY8 ADCY8 ATP1A1 ATP1A1 ADCY1 ADCY1 TPO TPO TG TG TTF1 TTF1 ITPR2 ITPR2 TSHR-2 TSHR-2 ADCY6 ADCY6 LOC111772111 LOC111772111 CREB3L1 CREB3L1 ATP1A2 ATP1A2 ADCY3 ADCY3 HSP90B1 HSP90B1 ATF2 ATF2 PLCB4 PLCB4 PRKACA PRKACA CGA CGA PRKCA PRKCA ATP1A3 ATP1A3 ADCY7 ADCY7 ITPR3 ITPR3 PRKACB PRKACB LRP2 LRP2 ALB ALB PRKCB PRKCB ENSECAP00000042890 ENSECAP00000042890 CREB3L3 CREB3L3 GPX3 GPX3 CREB5 CREB5 PLCB2 PLCB2 ITPR1 ITPR1 GPX2 GPX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CREB3cAMP responsive element binding protein 3. (390 aa)
LOC100050675Uncharacterized protein. (250 aa)
CANXCalnexin. (575 aa)
ATF4Activating transcription factor 4. (334 aa)
GPX6Glutathione peroxidase; Belongs to the glutathione peroxidase family. (220 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
PDIA4Protein disulfide-isomerase. (1161 aa)
GPX5Glutathione peroxidase; Belongs to the glutathione peroxidase family. (294 aa)
PAX8Paired box 8. (457 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
SERPINA7Serpin family A member 7; Belongs to the serpin family. (437 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
TTF2Transcription termination factor 2. (1167 aa)
TSHBThyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism. (138 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (354 aa)
GSRGlutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (622 aa)
DUOXA2Dual oxidase maturation factor 2. (320 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (465 aa)
TTRTransthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. (147 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (393 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
DUOX2Dual oxidase 2. (1545 aa)
GNAQG protein subunit alpha q. (441 aa)
IYDIodotyrosine deiodinase. (349 aa)
SLC5A5Solute carrier family 5 member 5; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (642 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
GPX7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
ATF6BActivating transcription factor 6 beta. (703 aa)
GPX8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
SLC26A4Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (780 aa)
ASGR2Asialoglycoprotein receptor 2. (310 aa)
ASGR1Asialoglycoprotein receptor 1. (284 aa)
HSPA5Endoplasmic reticulum chaperone BiP; Belongs to the heat shock protein 70 family. (654 aa)
DUOX1Dual oxidase 1. (1551 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1036 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. (1021 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1124 aa)
TPOThyroid peroxidase. (925 aa)
TGThyroglobulin. (2768 aa)
TTF1Transcription termination factor 1. (762 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
TSHR-2Uncharacterized protein. (122 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1206 aa)
LOC111772111Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (698 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (524 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1045 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1200 aa)
HSP90B1Heat shock protein 90 beta family member 1. (823 aa)
ATF2Activating transcription factor 2. (512 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1236 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (359 aa)
CGAGlycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. (132 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
LRP2LDL receptor related protein 2. (4673 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (620 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
ENSECAP00000042890Uncharacterized protein. (145 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (468 aa)
GPX3Glutathione peroxidase; Belongs to the glutathione peroxidase family. (225 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1273 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
GPX2Glutathione peroxidase; Belongs to the glutathione peroxidase family. (189 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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