STRINGSTRING
G6PC G6PC SOCS3 SOCS3 TNF TNF ADIPOQ ADIPOQ IRS2 IRS2 IRS1 IRS1 SLC2A4 SLC2A4 MAPK8 MAPK8 NPY NPY AKT2 AKT2 ADIPOR1 ADIPOR1 JAK2 JAK2 ACSL1 ACSL1 ACSL3 ACSL3 PRKAG1 PRKAG1 IRS4 IRS4 CPT1B-2 CPT1B-2 PRKAG2 PRKAG2 PRKAA2 PRKAA2 TRAF2 TRAF2 TRADD TRADD RELA RELA PCK1 PCK1 LEPR LEPR STK11 STK11 NFKB1 NFKB1 POMC POMC AGRP AGRP ACACB ACACB NFKBIE NFKBIE AKT3 AKT3 IKBKG IKBKG PRKAB2 PRKAB2 PRKAA1 PRKAA1 RXRB RXRB NFKBIA NFKBIA G6PC3 G6PC3 RXRG RXRG PTPN11 PTPN11 PCK2 PCK2 CPT1C CPT1C ACSBG2 ACSBG2 PRKAB1 PRKAB1 G6PC2 G6PC2 ACSL6 ACSL6 CPT1A CPT1A IKBKB IKBKB CD36 CD36 ACSL5 ACSL5 CAMKK2 CAMKK2 AKT1 AKT1 MAPK9 MAPK9 PPARA PPARA PRKCQ PRKCQ LEP LEP PPARGC1A PPARGC1A STAT3 STAT3 PRKAG3 PRKAG3 ACSBG1 ACSBG1 CHUK CHUK LOC100069009 LOC100069009 ACSL4 ACSL4 SLC2A1 SLC2A1 RXRA RXRA ADIPOR2 ADIPOR2 NFKBIB NFKBIB MAPK10 MAPK10 MTOR MTOR TNFRSF1B TNFRSF1B TNFRSF1A TNFRSF1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (301 aa)
IRS2Insulin receptor substrate 2. (1401 aa)
IRS1Insulin receptor substrate 1. (1239 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
NPYNeuropeptide Y. (157 aa)
AKT2Non-specific serine/threonine protein kinase. (528 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
ACSL1Acyl-CoA synthetase long chain family member 1. (698 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (719 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa)
IRS4Insulin receptor substrate 4. (1355 aa)
CPT1B-2Carnitine palmitoyltransferase 1B. (893 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (564 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
TRADDTNFRSF1A associated via death domain. (312 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
LEPRLeptin receptor. (1165 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
NFKB1Nuclear factor kappa B subunit 1. (1049 aa)
POMCMelanotropin beta; MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes; Belongs to the POMC family. (332 aa)
AGRPAgouti related neuropeptide. (131 aa)
ACACBAcetyl-CoA carboxylase beta. (2453 aa)
NFKBIENFKB inhibitor epsilon. (362 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (451 aa)
PRKAA1Non-specific serine/threonine protein kinase. (633 aa)
RXRBRetinoid X receptor beta. (536 aa)
NFKBIANFKB inhibitor alpha. (543 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
RXRGRetinoid X receptor gamma. (463 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (606 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (646 aa)
CPT1CCarnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (803 aa)
ACSBG2Acyl-CoA synthetase bubblegum family member 2. (703 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (345 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
ACSL6Acyl-CoA synthetase long chain family member 6. (730 aa)
CPT1ACarnitine O-palmitoyltransferase 1, liver isoform; Belongs to the carnitine/choline acetyltransferase family. (1029 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (770 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
ACSL5Acyl-CoA synthetase long chain family member 5. (683 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (578 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
MAPK9Mitogen-activated protein kinase. (446 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (811 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (189 aa)
PPARGC1APPARG coactivator 1 alpha. (839 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (556 aa)
ACSBG1Acyl-CoA synthetase bubblegum family member 1. (738 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
LOC100069009Uncharacterized protein. (571 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (711 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (554 aa)
RXRARetinoid X receptor alpha. (677 aa)
ADIPOR2Adiponectin receptor 2. (386 aa)
NFKBIBNFKB inhibitor beta. (371 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2573 aa)
TNFRSF1BTNF receptor superfamily member 1B. (481 aa)
TNFRSF1ATNF receptor superfamily member 1A. (475 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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