(63 nodes) Renin secretion network (Equus caballus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	GNAI1	G protein subunit alpha i1. (354 aa)
	LOC100054420	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (662 aa)
	GNAI2	G protein subunit alpha i2. (355 aa)
	NPR1	Guanylate cyclase. (1058 aa)
	AGTR1	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (390 aa)
	LOC100050675	Uncharacterized protein. (250 aa)
	ADRB2	Adrenoceptor beta 2. (484 aa)
	EDN3	Endothelin 3. (270 aa)
	CALML3	Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
	KCNJ2	Potassium voltage-gated channel subfamily J member 2. (427 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (525 aa)
	CALM1	Uncharacterized protein; Belongs to the calmodulin family. (336 aa)
	PTGER2	Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (353 aa)
	GNAI3	G protein subunit alpha i3. (354 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
	PTGER4	Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (490 aa)
	EDN1	Endothelin 1. (202 aa)
	KCNMA1	Potassium calcium-activated channel subfamily M alpha 1. (1278 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
	ORAI1	ORAI calcium release-activated calcium modulator 1. (313 aa)
	ACE	Angiotensin-converting enzyme. (1313 aa)
	NPPA	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family. (153 aa)
	LOC100052500	VWFA domain-containing protein. (904 aa)
	ADRB3	Adrenoceptor beta 3. (403 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (483 aa)
	CACNA1F	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1974 aa)
	CACNA1D	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2209 aa)
	ADORA1	Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
	GUCY1A2	Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (727 aa)
	GNAQ	G protein subunit alpha q. (441 aa)
	CLCA1	Calcium-activated chloride channel regulator 1; May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC (By similarity). (984 aa)
	REN	Renin; Belongs to the peptidase A1 family. (407 aa)
	CACNA1S	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1765 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
	GUCY1B1	Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (619 aa)
	CALML4	Calmodulin like 4. (197 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2184 aa)
	PDE1A	Phosphodiesterase. (542 aa)
	PRKG2	cGMP-dependent protein kinase. (762 aa)
	PDE3B	Phosphodiesterase. (1125 aa)
	ADRB1	Adrenoceptor beta 1. (467 aa)
	PDE3A	Phosphodiesterase. (1144 aa)
	ADCYAP1	Adenylate cyclase activating polypeptide 1. (170 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1206 aa)
	WDR92	Protein phosphatase 3 regulatory subunit B, alpha. (496 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1236 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (359 aa)
	CALML5	Calmodulin like 5. (149 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (534 aa)
	CTSB	Cathepsin B; Belongs to the peptidase C1 family. (384 aa)
	ENSECAP00000033310	Uncharacterized protein. (330 aa)
	GUCY1A1	Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (717 aa)
	ENSECAP00000035509	VWFA domain-containing protein. (470 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
	EDN2	Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. (274 aa)
	AQP1	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (307 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1273 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
	PDE1C	Phosphodiesterase. (769 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE	AGT	ENSECAP00000011650	ENSECAP00000013428	Angiotensin-converting enzyme.	Angiotensinogen; Belongs to the serpin family.	0.965
ACE	AGTR1	ENSECAP00000011650	ENSECAP00000000954	Angiotensin-converting enzyme.	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family.	0.675
ACE	EDN1	ENSECAP00000011650	ENSECAP00000009534	Angiotensin-converting enzyme.	Endothelin 1.	0.559
ACE	NPPA	ENSECAP00000011650	ENSECAP00000012495	Angiotensin-converting enzyme.	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family.	0.500
ACE	REN	ENSECAP00000011650	ENSECAP00000016896	Angiotensin-converting enzyme.	Renin; Belongs to the peptidase A1 family.	0.956
ADCY5	ADCY6	ENSECAP00000008418	ENSECAP00000027555	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.955
ADCY5	CALM1	ENSECAP00000008418	ENSECAP00000007162	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the calmodulin family.	0.784
ADCY5	CALML3	ENSECAP00000008418	ENSECAP00000004472	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 3; Belongs to the calmodulin family.	0.784
ADCY5	CALML4	ENSECAP00000008418	ENSECAP00000019278	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 4.	0.681
ADCY5	CALML5	ENSECAP00000008418	ENSECAP00000031692	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 5.	0.752
ADCY5	GNAI1	ENSECAP00000008418	ENSECAP00000000170	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i1.	0.938
ADCY5	GNAI2	ENSECAP00000008418	ENSECAP00000000530	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i2.	0.958
ADCY5	GNAI3	ENSECAP00000008418	ENSECAP00000007976	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i3.	0.938
ADCY5	LOC100050675	ENSECAP00000008418	ENSECAP00000003182	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.904
ADCY5	NPPA	ENSECAP00000008418	ENSECAP00000012495	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family.	0.443
ADCY5	PDE1A	ENSECAP00000008418	ENSECAP00000020139	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.685
ADCY5	PDE1C	ENSECAP00000008418	ENSECAP00000055085	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.689
ADCY5	PDE3A	ENSECAP00000008418	ENSECAP00000023248	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.839
ADCY5	PDE3B	ENSECAP00000008418	ENSECAP00000022374	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.745
ADCY5	PLCB1	ENSECAP00000008418	ENSECAP00000018741	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.533