STRINGSTRING
GAD2 GAD2 LOC111768663 LOC111768663 LTA LTA TNF TNF DQA-2 DQA-2 PTPRN PTPRN HSPD1 HSPD1 CPE CPE LOC100055638 LOC100055638 PRF1 PRF1 DRA DRA IL12B IL12B GAD1 GAD1 FAS FAS IL2 IL2 F6UE14_HORSE F6UE14_HORSE FASLG FASLG HLA-DOB HLA-DOB LOC100060996 LOC100060996 IL1A IL1A INS INS IL12A IL12A HLA-DOA HLA-DOA DRB DRB ENSECAP00000025114 ENSECAP00000025114 LOC111767719 LOC111767719 LOC111772100 LOC111772100 LOC111768185 LOC111768185 EQMHCC1 EQMHCC1 ICA1 ICA1 IFNG IFNG CD80 CD80 DQB DQB LOC100056182 LOC100056182 DRB-2 DRB-2 CD86 CD86 LOC100054114 LOC100054114 LOC106783094 LOC106783094 CD28 CD28 LOC100049805 LOC100049805 LOC100050473 LOC100050473 LOC100055651 LOC100055651 MHCB3 MHCB3 HLA-DMA HLA-DMA LOC100059994 LOC100059994 LOC100050711 LOC100050711 LOC111767413 LOC111767413 DRB-3 DRB-3 IL1B IL1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GAD2Glutamate decarboxylase 2. (585 aa)
LOC111768663Peptidase S1 domain-containing protein. (255 aa)
LTATumor necrosis factor ligand 1E; Belongs to the tumor necrosis factor family. (204 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
DQA-2Ig-like domain-containing protein; Belongs to the MHC class II family. (293 aa)
PTPRNProtein tyrosine phosphatase receptor type N. (979 aa)
HSPD1Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (573 aa)
CPECarboxypeptidase E. (476 aa)
LOC100055638Uncharacterized protein. (513 aa)
PRF1Perforin 1. (555 aa)
DRAMHC class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (254 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (329 aa)
GAD1Glutamate decarboxylase 1. (594 aa)
FASFas cell surface death receptor. (365 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (149 aa)
F6UE14_HORSEMHC_I-like_Ag-recog domain-containing protein. (212 aa)
FASLGTumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family. (283 aa)
HLA-DOBMHC class II histocompatibility antigen, DO beta chain. (258 aa)
LOC100060996MHC class II antigen. (263 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (256 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (262 aa)
DRBIg-like domain-containing protein. (275 aa)
ENSECAP00000025114Ig-like domain-containing protein; Belongs to the MHC class I family. (455 aa)
LOC111767719Ig-like domain-containing protein. (187 aa)
LOC111772100Ig-like domain-containing protein. (173 aa)
LOC111768185Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
EQMHCC1Ig-like domain-containing protein; Belongs to the MHC class I family. (445 aa)
ICA1Islet cell autoantigen 1. (510 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
CD80CD80 molecule. (305 aa)
DQBIg-like domain-containing protein. (309 aa)
LOC100056182Uncharacterized protein; Belongs to the MHC class I family. (362 aa)
DRB-2Ig-like domain-containing protein. (288 aa)
CD86CD86 molecule. (335 aa)
LOC100054114Ig-like domain-containing protein; Belongs to the MHC class I family. (347 aa)
LOC106783094Ig-like domain-containing protein. (229 aa)
CD28CD28 molecule. (228 aa)
LOC100049805Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (302 aa)
LOC100050473Ig-like domain-containing protein; Belongs to the MHC class I family. (389 aa)
LOC100055651Peptidase S1 domain-containing protein. (244 aa)
MHCB3Ig-like domain-containing protein; Belongs to the MHC class I family. (433 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (314 aa)
LOC100059994Uncharacterized protein; Belongs to the MHC class I family. (592 aa)
LOC100050711Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (269 aa)
LOC111767413Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (252 aa)
DRB-3MHC class II antigen. (266 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (268 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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