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GNAI1 GNAI1 GNAI2 GNAI2 KCNJ16 KCNJ16 LOC100050675 LOC100050675 CALML3 CALML3 KCNJ2 KCNJ2 ATP1B2 ATP1B2 KCNJ15 KCNJ15 MYLK3 MYLK3 CALM1 CALM1 GNAI3 GNAI3 CHRM3 CHRM3 CFTR CFTR ADCY5 ADCY5 SLC9A1 SLC9A1 GAST GAST PLCB3 PLCB3 CCKBR CCKBR ATP4A ATP4A ADCY4 ADCY4 ATP1B4 ATP1B4 ACTB ACTB ADCY2 ADCY2 ATP1B1 ATP1B1 GNAQ GNAQ EZR EZR PRKCG PRKCG ATP1B3 ATP1B3 CAMK2A CAMK2A ATP4B ATP4B PLCB1 PLCB1 SSTR2 SSTR2 CALML4 CALML4 SST SST ADCY9 ADCY9 CAMK2D CAMK2D ATP1A4 ATP1A4 ADCY8 ADCY8 ATP1A1 ATP1A1 KCNJ1 KCNJ1 ADCY1 ADCY1 KCNQ1 KCNQ1 ITPR2 ITPR2 ADCY6 ADCY6 ATP1A2 ATP1A2 ADCY3 ADCY3 PLCB4 PLCB4 PRKACA PRKACA CALML5 CALML5 MYLK2 MYLK2 SLC26A7 SLC26A7 PRKCA PRKCA MYLK MYLK ATP1A3 ATP1A3 ADCY7 ADCY7 ITPR3 ITPR3 PRKACB PRKACB PRKCB PRKCB CAMK2B CAMK2B HRH2 HRH2 MYLK4 MYLK4 CAMK2G CAMK2G KCNK10 KCNK10 KCNE2 KCNE2 SLC4A2 SLC4A2 PLCB2 PLCB2 ITPR1 ITPR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GNAI1G protein subunit alpha i1. (354 aa)
GNAI2G protein subunit alpha i2. (355 aa)
KCNJ16Potassium voltage-gated channel subfamily J member 16. (419 aa)
LOC100050675Uncharacterized protein. (250 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
KCNJ2Potassium voltage-gated channel subfamily J member 2. (427 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
KCNJ15Potassium voltage-gated channel subfamily J member 15. (375 aa)
MYLK3Myosin light chain kinase 3. (809 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (336 aa)
GNAI3G protein subunit alpha i3. (354 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (603 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1541 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (814 aa)
GASTBig gastrin; Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. (107 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
CCKBRCholecystokinin B receptor; Belongs to the G-protein coupled receptor 1 family. (454 aa)
ATP4ASodium/potassium-transporting ATPase subunit alpha. (1046 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (354 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (377 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
GNAQG protein subunit alpha q. (441 aa)
EZREzrin. (830 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha. (563 aa)
ATP4BSodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (291 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
SSTR2Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
CALML4Calmodulin like 4. (197 aa)
SSTSomatostatin. (116 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (543 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1036 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. (1021 aa)
KCNJ1Potassium voltage-gated channel subfamily J member 1. (391 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1124 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (778 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1206 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1045 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1200 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1236 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (359 aa)
CALML5Calmodulin like 5. (149 aa)
MYLK2Myosin light chain kinase 2. (938 aa)
SLC26A7Anion exchange transporter. (656 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
MYLKMyosin light chain kinase. (2069 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (656 aa)
HRH2Histamine receptor H2; Belongs to the G-protein coupled receptor 1 family. (580 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (432 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (556 aa)
KCNK10Potassium two pore domain channel subfamily K member 10; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (580 aa)
KCNE2Potassium voltage-gated channel subfamily E regulatory subunit 2. (123 aa)
SLC4A2Anion exchange protein 2; Plasma membrane anion exchange protein of wide distribution. Belongs to the anion exchanger (TC 2.A.31) family. (1288 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1273 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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