(46 nodes) Cocaine addiction network (Equus caballus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	CREB3	cAMP responsive element binding protein 3. (390 aa)
	GNAI1	G protein subunit alpha i1. (354 aa)
	GNAI2	G protein subunit alpha i2. (355 aa)
	MAOB	Amine oxidase. (520 aa)
	CDK5R1	Cyclin-dependent kinase 5 activator. (307 aa)
	LOC100050675	Uncharacterized protein. (250 aa)
	ATF4	Activating transcription factor 4. (334 aa)
	PDYN	Prodynorphin. (256 aa)
	CREB3L2	cAMP responsive element binding protein 3 like 2. (520 aa)
	GRM3	Glutamate metabotropic receptor 3. (879 aa)
	GRM2	Glutamate metabotropic receptor 2. (872 aa)
	DDC	Dopa decarboxylase. (480 aa)
	GNAI3	G protein subunit alpha i3. (354 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
	DRD1	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (446 aa)
	GRIN3A	Glutamate ionotropic receptor NMDA type subunit 3A. (1115 aa)
	SLC18A1	Solute carrier family 18 member A1. (525 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (551 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (1049 aa)
	CREB3L4	cAMP responsive element binding protein 3 like 4. (393 aa)
	PPP1R1B	Protein phosphatase 1 regulatory inhibitor subunit 1B. (205 aa)
	ATF6B	Activating transcription factor 6 beta. (703 aa)
	GRIN2B	Glutamate ionotropic receptor NMDA type subunit 2B. (1497 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (340 aa)
	SLC18A2	Solute carrier family 18 member A2. (517 aa)
	CDK5	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	SLC6A3	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (617 aa)
	GRIN1	Glutamate ionotropic receptor NMDA type subunit 1. (1004 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (524 aa)
	ATF2	Activating transcription factor 2. (512 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (359 aa)
	GRIA2	Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
	BDNF	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (299 aa)
	GRIN2C	Glutamate ionotropic receptor NMDA type subunit 2C. (1226 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
	MAOA	Amine oxidase [flavin-containing] A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity). (922 aa)
	DRD2	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
	GRIN3B	Glutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1044 aa)
	DLG4	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (767 aa)
	GRIN2A	Glutamate ionotropic receptor NMDA type subunit 2A. (1452 aa)
	GPSM1	G protein signaling modulator 1. (705 aa)
	RGS9	Regulator of G protein signaling 9. (675 aa)
	CREB3L3	cAMP responsive element binding protein 3 like 3. (468 aa)
	CREB5	Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
	TH	Tyrosine hydroxylase. (526 aa)
	FOSB	FosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY5	CREB3L3	ENSECAP00000008418	ENSECAP00000051022	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP responsive element binding protein 3 like 3.	0.420
ADCY5	GNAI1	ENSECAP00000008418	ENSECAP00000000170	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i1.	0.938
ADCY5	GNAI2	ENSECAP00000008418	ENSECAP00000000530	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i2.	0.958
ADCY5	GNAI3	ENSECAP00000008418	ENSECAP00000007976	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i3.	0.938
ADCY5	LOC100050675	ENSECAP00000008418	ENSECAP00000003182	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.904
ADCY5	PRKACA	ENSECAP00000008418	ENSECAP00000030791	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.929
ADCY5	PRKACB	ENSECAP00000008418	ENSECAP00000039657	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.929
ATF2	ATF4	ENSECAP00000030209	ENSECAP00000004969	Activating transcription factor 2.	Activating transcription factor 4.	0.938
ATF2	ATF6B	ENSECAP00000030209	ENSECAP00000019270	Activating transcription factor 2.	Activating transcription factor 6 beta.	0.945
ATF2	CREB3	ENSECAP00000030209	ENSECAP00000000131	Activating transcription factor 2.	cAMP responsive element binding protein 3.	0.944
ATF2	CREB3L1	ENSECAP00000030209	ENSECAP00000028022	Activating transcription factor 2.	cAMP responsive element binding protein 3 like 1.	0.905
ATF2	CREB3L2	ENSECAP00000030209	ENSECAP00000005839	Activating transcription factor 2.	cAMP responsive element binding protein 3 like 2.	0.910
ATF2	CREB3L3	ENSECAP00000030209	ENSECAP00000051022	Activating transcription factor 2.	cAMP responsive element binding protein 3 like 3.	0.904
ATF2	CREB3L4	ENSECAP00000030209	ENSECAP00000015241	Activating transcription factor 2.	cAMP responsive element binding protein 3 like 4.	0.904
ATF2	CREB5	ENSECAP00000030209	ENSECAP00000051621	Activating transcription factor 2.	Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription.	0.956
ATF2	JUN	ENSECAP00000030209	ENSECAP00000021482	Activating transcription factor 2.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.995
ATF2	PRKACA	ENSECAP00000030209	ENSECAP00000030791	Activating transcription factor 2.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.930
ATF2	PRKACB	ENSECAP00000030209	ENSECAP00000039657	Activating transcription factor 2.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.930
ATF4	ATF2	ENSECAP00000004969	ENSECAP00000030209	Activating transcription factor 4.	Activating transcription factor 2.	0.938
ATF4	ATF6B	ENSECAP00000004969	ENSECAP00000019270	Activating transcription factor 4.	Activating transcription factor 6 beta.	0.933