STRINGSTRING
GNAI1 GNAI1 GNAI2 GNAI2 TLR6 TLR6 TNF TNF MYD88 MYD88 LOC100050675 LOC100050675 TICAM1 TICAM1 BDKRB2 BDKRB2 CD3G CD3G CASP8 CASP8 MAPK11 MAPK11 IFNB1 IFNB1 PIK3CD PIK3CD CALR CALR MAPK8 MAPK8 AKT2 AKT2 IL10 IL10 IFNGR1 IFNGR1 GNAI3 GNAI3 TLR4 TLR4 PPP2CB PPP2CB TGFB1 TGFB1 PLCB3 PLCB3 IL12B IL12B FAS FAS ACE ACE RELA RELA FOS FOS TLR9 TLR9 PPP2R2C PPP2R2C MAPK3 MAPK3 MAPK14 MAPK14 IRAK4 IRAK4 GNA15 GNA15 LOC100062428 LOC100062428 TGFBR2 TGFBR2 CXCL8 CXCL8 PIK3CA PIK3CA NFKB1 NFKB1 IL2 IL2 FASLG FASLG IL6 IL6 MAPK12 MAPK12 TLR2 TLR2 CD3D CD3D GNAQ GNAQ C1QB C1QB SERPINE1 SERPINE1 AKT3 AKT3 CD247 CD247 PIK3R1 PIK3R1 GNA14 GNA14 IKBKG IKBKG TRAF6 TRAF6 PLCB1 PLCB1 FADD FADD CFLAR CFLAR NFKBIA NFKBIA CCL2 CCL2 JUN JUN PIK3CB PIK3CB IL12A IL12A CCL5 CCL5 ADCY1 ADCY1 MAP2K4 MAP2K4 PIK3R2 PIK3R2 LOC111767719 LOC111767719 LOC111772100 LOC111772100 LOC111768185 LOC111768185 SMAD2 SMAD2 IKBKB IKBKB PLCB4 PLCB4 IFNG IFNG LOC100052122 LOC100052122 CD3E CD3E AKT1 AKT1 GNA11 GNA11 MAPK9 MAPK9 CHUK CHUK PPP2R2D PPP2R2D PPP2R2B PPP2R2B GNAO1 GNAO1 MAPK13 MAPK13 PPP2R2A PPP2R2A C1QC C1QC LOC106783094 LOC106783094 PPP2R1B PPP2R1B IRAK1 IRAK1 GNAL GNAL TGFBR1 TGFBR1 MAPK1 MAPK1 PPP2R1A PPP2R1A MAPK10 MAPK10 LOC100147174 LOC100147174 LOC100060505 LOC100060505 TGFB2 TGFB2 KNG1 KNG1 PLCB2 PLCB2 IL1B IL1B TNFRSF1A TNFRSF1A IFNGR2 IFNGR2
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GNAI1G protein subunit alpha i1. (354 aa)
GNAI2G protein subunit alpha i2. (355 aa)
TLR6Toll-like receptor. (859 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
LOC100050675Uncharacterized protein. (250 aa)
TICAM1Toll like receptor adaptor molecule 1. (698 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (414 aa)
CD3GCD3g molecule. (178 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (464 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
IFNB1Interferon beta; Has antiviral, antibacterial and anticancer activities. (186 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CALRCalreticulin. (412 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
AKT2Non-specific serine/threonine protein kinase. (528 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (249 aa)
IFNGR1Interferon gamma receptor 1. (472 aa)
GNAI3G protein subunit alpha i3. (354 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (329 aa)
FASFas cell surface death receptor. (365 aa)
ACEAngiotensin-converting enzyme. (1313 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
GNA15G protein subunit alpha 15. (374 aa)
LOC100062428Calreticulin. (408 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (687 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity). (101 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NFKB1Nuclear factor kappa B subunit 1. (1049 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (149 aa)
FASLGTumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family. (283 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa)
MAPK12Mitogen-activated protein kinase. (365 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
CD3DCD3d molecule. (165 aa)
GNAQG protein subunit alpha q. (441 aa)
C1QBComplement C1q B chain. (252 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CD247CD247 molecule. (167 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
GNA14G protein subunit alpha 14. (355 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (212 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (510 aa)
NFKBIANFKB inhibitor alpha. (543 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (99 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (340 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (256 aa)
CCL5C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1124 aa)
MAP2K4Mitogen-activated protein kinase kinase 4. (531 aa)
PIK3R2Uncharacterized protein. (479 aa)
LOC111767719Ig-like domain-containing protein. (187 aa)
LOC111772100Ig-like domain-containing protein. (173 aa)
LOC111768185Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
SMAD2Mothers against decapentaplegic homolog. (610 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (770 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1236 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
LOC100052122Uncharacterized protein. (461 aa)
CD3ECD3e molecule. (246 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
GNA11G protein subunit alpha 11. (528 aa)
MAPK9Mitogen-activated protein kinase. (446 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (682 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (595 aa)
GNAO1G protein subunit alpha o1. (354 aa)
MAPK13Mitogen-activated protein kinase. (421 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
C1QCComplement C1q C chain. (706 aa)
LOC106783094Ig-like domain-containing protein. (229 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (783 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (805 aa)
GNALG protein subunit alpha L. (445 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (666 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
LOC100147174Uncharacterized protein. (186 aa)
LOC100060505Uncharacterized protein. (1662 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
KNG1Kininogen 1. (653 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1273 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (268 aa)
TNFRSF1ATNF receptor superfamily member 1A. (475 aa)
IFNGR2Interferon gamma receptor 2. (461 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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