STRINGSTRING
CD1A3 CD1A3 LAMC3 LAMC3 TNF TNF LOC100050675 LOC100050675 LAMB4 LAMB4 CD1B2 CD1B2 FN1 FN1 PIK3CD PIK3CD C9 C9 LAMB3 LAMB3 PRDX1 PRDX1 IL10 IL10 LAMB1 LAMB1 CSF2 CSF2 TLR4 TLR4 COL4A4 COL4A4 TGFB1 TGFB1 CD1C CD1C SERPINB9 SERPINB9 PLCB3 PLCB3 IL12B IL12B CD1A7 CD1A7 RELA RELA CD1E1 CD1E1 GNA15 GNA15 CXCL8 CXCL8 PIK3CA PIK3CA NFKB1 NFKB1 SERPINB6 SERPINB6 IL6 IL6 ARG2 ARG2 TLR2 TLR2 GNAQ GNAQ ITGAM ITGAM LAMA4 LAMA4 PRKCG PRKCG PIK3R1 PIK3R1 HSPB1 HSPB1 GNA14 GNA14 COL4A1 COL4A1 PLCB1 PLCB1 CASP3 CASP3 LAMB2 LAMB2 RAB5B RAB5B LAMC1 LAMC1 ARG1 ARG1 PIK3CB PIK3CB IL12A IL12A COL1A2 COL1A2 RAB5C RAB5C ADCY1 ADCY1 LAMA2 LAMA2 PIK3R2 PIK3R2 ENSECAP00000023544 ENSECAP00000023544 RAB7B RAB7B IL1R1 IL1R1 PTK2 PTK2 ENSECAP00000026008 ENSECAP00000026008 ENSECAP00000026102 ENSECAP00000026102 CD1A1 CD1A1 RAB7A RAB7A LOC111768185 LOC111768185 PLCB4 PLCB4 IFNG IFNG PRKACA PRKACA LAMC2 LAMC2 LOC100052122 LOC100052122 LOC111772122 LOC111772122 GNA11 GNA11 PRKCA PRKCA C8B C8B SERPINB13 SERPINB13 LAMA5 LAMA5 ACTN1 ACTN1 PRKACB PRKACB LAMA3 LAMA3 RAB5A RAB5A LAMA1 LAMA1 CXCL1 CXCL1 PRKCB PRKCB CD1B1 CD1B1 COL4A2 COL4A2 ACTN4 ACTN4 CD1E2 CD1E2 GNAL GNAL CD1A5 CD1A5 CD1D CD1D IL1R2 IL1R2 ITGB2 ITGB2 CTSG CTSG COL4A5 COL4A5 C8A C8A TGFB2 TGFB2 PLCB2 PLCB2 IL1B IL1B COL4A6 COL4A6 COL4A3 COL4A3 COL1A1 COL1A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD1A3Ig-like domain-containing protein. (347 aa)
LAMC3Laminin subunit gamma 3. (1578 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
LOC100050675Uncharacterized protein. (250 aa)
LAMB4Laminin subunit beta 4. (1747 aa)
CD1B2Ig-like domain-containing protein. (410 aa)
FN1Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). (2477 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
C9Complement component C9; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC. (547 aa)
LAMB3Laminin subunit beta 3. (1185 aa)
PRDX1Peroxiredoxin 1. (199 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (249 aa)
LAMB1Laminin subunit beta 1. (1834 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (152 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa)
COL4A4Collagen type IV alpha 4 chain. (1691 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
CD1CIg-like domain-containing protein. (355 aa)
SERPINB9Serpin family B member 9; Belongs to the serpin family. (375 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (329 aa)
CD1A7Ig-like domain-containing protein. (340 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
CD1E1Ig-like domain-containing protein. (392 aa)
GNA15G protein subunit alpha 15. (374 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity). (101 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NFKB1Nuclear factor kappa B subunit 1. (1049 aa)
SERPINB6Serpin family B member 6; Belongs to the serpin family. (486 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa)
ARG2Arginase. (351 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
GNAQG protein subunit alpha q. (441 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1142 aa)
LAMA4Laminin subunit alpha 4. (1824 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (209 aa)
GNA14G protein subunit alpha 14. (355 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
CASP3Caspase-3-like protein; Belongs to the peptidase C14A family. (277 aa)
LAMB2Laminin subunit beta 2. (1801 aa)
RAB5BRAB5B, member RAS oncogene family. (215 aa)
LAMC1Laminin subunit gamma 1. (1612 aa)
ARG1Arginase. (348 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (256 aa)
COL1A2Collagen type I alpha 2 chain. (1364 aa)
RAB5CRAB5C, member RAS oncogene family. (248 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1124 aa)
LAMA2Laminin subunit alpha 2. (3122 aa)
PIK3R2Uncharacterized protein. (479 aa)
ENSECAP00000023544Uncharacterized protein. (958 aa)
RAB7BRAB7B, member RAS oncogene family. (308 aa)
IL1R1Interleukin 1 receptor type 1. (578 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1093 aa)
ENSECAP00000026008Ig-like domain-containing protein. (182 aa)
ENSECAP00000026102VWFD domain-containing protein. (310 aa)
CD1A1Ig-like domain-containing protein. (339 aa)
RAB7ARAB7A, member RAS oncogene family. (229 aa)
LOC111768185Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1236 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (359 aa)
LAMC2Laminin subunit gamma-2; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell-scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells. (1193 aa)
LOC100052122Uncharacterized protein. (461 aa)
LOC111772122Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (369 aa)
GNA11G protein subunit alpha 11. (528 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
C8BComplement C8 beta chain. (590 aa)
SERPINB13Serpin family B member 13; Belongs to the serpin family. (390 aa)
LAMA5Laminin subunit alpha 5. (3696 aa)
ACTN1Actinin alpha 1. (959 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
LAMA3Laminin subunit alpha 3. (3331 aa)
RAB5ARAB5A, member RAS oncogene family. (215 aa)
LAMA1Laminin subunit alpha 1. (3127 aa)
CXCL1C-X-C motif chemokine. (113 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
CD1B1CD1 protein. (333 aa)
COL4A2Collagen type IV alpha 2 chain. (1867 aa)
ACTN4Actinin alpha 4. (933 aa)
CD1E2Ig-like domain-containing protein. (356 aa)
GNALG protein subunit alpha L. (445 aa)
CD1A5CD1 protein. (349 aa)
CD1DIg-like domain-containing protein. (439 aa)
IL1R2Interleukin 1 receptor type 2. (488 aa)
ITGB2Integrin beta. (873 aa)
CTSGCathepsin G. (256 aa)
COL4A5Collagen type IV alpha 5 chain. (1691 aa)
C8AComplement C8 alpha chain. (589 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1273 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (268 aa)
COL4A6Collagen type IV alpha 6 chain. (1708 aa)
COL4A3Collagen type IV alpha 3 chain. (1761 aa)
COL1A1Collagen type I alpha 1 chain. (1521 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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