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| | TLR6 | Toll-like receptor. (859 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa) |
| | IFND2 | Uncharacterized protein. (170 aa) |
| | CEBPG | CCAAT enhancer binding protein gamma. (215 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (464 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (364 aa) |
| | CALML3 | Calmodulin like 3; Belongs to the calmodulin family. (149 aa) |
| | IFNB1 | Interferon beta; Has antiviral, antibacterial and anticancer activities. (186 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (194 aa) |
| | LOC100053210 | Uncharacterized protein. (184 aa) |
| | DQA-2 | Ig-like domain-containing protein; Belongs to the MHC class II family. (293 aa) |
| | IL10RB | Interleukin 10 receptor subunit beta. (386 aa) |
| | SPHK2 | Sphingosine kinase 2. (654 aa) |
| | HSPA9 | Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (679 aa) |
| | NFYA | Nuclear transcription factor Y subunit alpha. (382 aa) |
| | CLEC4E | C-type lectin domain family 4 member E. (217 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase. (528 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (525 aa) |
| | NFYB | Nuclear transcription factor Y subunit beta; Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors (By similarity). (207 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (249 aa) |
| | CALM1 | Uncharacterized protein; Belongs to the calmodulin family. (336 aa) |
| | HSPD1 | Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (573 aa) |
| | FCER1G | Fc fragment of IgE receptor Ig. (86 aa) |
| | IFNGR1 | Interferon gamma receptor 1. (472 aa) |
| | EP300 | E1A binding protein p300. (2430 aa) |
| | JAK2 | Tyrosine-protein kinase. (1131 aa) |
| | TLR4 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa) |
| | TCIRG1 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa) |
| | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa) |
| | TGFB1 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | PLK3 | Serine/threonine-protein kinase PLK. (647 aa) |
| | SRC | Tyrosine-protein kinase. (551 aa) |
| | TIRAP | TIR domain containing adaptor protein. (234 aa) |
| | DRA | MHC class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (254 aa) |
| | MRC2 | Mannose receptor C type 2. (1482 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (329 aa) |
| | IRAK2 | Interleukin 1 receptor associated kinase 2. (621 aa) |
| | TRADD | TNFRSF1A associated via death domain. (312 aa) |
| | MALT1 | MALT1 paracaspase. (850 aa) |
| | ECATH-3 | Myeloid cathelicidin 3. (170 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (551 aa) |
| | TLR9 | Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa) |
| | CYCS | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | ATP6AP1 | ATPase H+ transporting accessory protein 1. (467 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa) |
| | LBP | Lipopolysaccharide binding protein. (481 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | BAD | BCL2 associated agonist of cell death. (167 aa) |
| | IL10RA | Interleukin 10 receptor subunit alpha. (572 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (1049 aa) |
| | ATP6V0D2 | V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa) |
| | ATP6V0D1 | V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa) |
| | ECATH-2 | Myeloid cathelicidin 2. (157 aa) |
| | VDR | Vitamin D receptor. (427 aa) |
| | LOC111768755 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (144 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (192 aa) |
| | ATP6V0A1 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (839 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1013 aa) |
| | ATP6V0A4 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (862 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (365 aa) |
| | TLR2 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa) |
| | ITGAM | Integrin subunit alpha M; Belongs to the integrin alpha chain family. (1142 aa) |
| | JAK1 | Tyrosine-protein kinase. (1141 aa) |
| | CARD9 | Caspase recruitment domain family member 9. (537 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | CAMK2A | Calcium/calmodulin dependent protein kinase II alpha. (563 aa) |
| | HLA-DOB | MHC class II histocompatibility antigen, DO beta chain. (258 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa) |
| | CD209 | C-type lectin domain-containing protein. (238 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (212 aa) |
| | CALML4 | Calmodulin like 4. (197 aa) |
| | LOC100060996 | MHC class II antigen. (263 aa) |
| | IL23A | Interleukin-23 subunit alpha; Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tu [...] (192 aa) |
| | CASP3 | Caspase-3-like protein; Belongs to the peptidase C14A family. (277 aa) |
| | CTSS | Cathepsin S; Belongs to the peptidase C1 family. (332 aa) |
| | RAB5B | RAB5B, member RAS oncogene family. (215 aa) |
| | LOC100066738 | C-type lectin domain-containing protein. (242 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa) |
| | PLA2R1 | Phospholipase A2 receptor 1. (1625 aa) |
| | ITGAD | Integrin subunit alpha X; Belongs to the integrin alpha chain family. (1203 aa) |
| | CASP10 | Caspase 10; Belongs to the peptidase C14A family. (478 aa) |
| | ATP6V0B | ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (205 aa) |
| | CAMK2D | Calcium/calmodulin dependent protein kinase II delta. (543 aa) |
| | ATP6V0A2 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (999 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (256 aa) |
| | RFX5 | Regulatory factor X5. (606 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1256 aa) |
| | CORO1A | Coronin; Belongs to the WD repeat coronin family. (461 aa) |
| | CREBBP | CREB binding protein. (2442 aa) |
| | BCL10 | BCL10 immune signaling adaptor. (374 aa) |
| | RAB5C | RAB5C, member RAS oncogene family. (248 aa) |
| | CYP27B1 | Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa) |
| | ATP6V0C | V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa) |
| | MRC1 | Mannose receptor C-type 1. (1514 aa) |
| | CEBPB | CCAAT/enhancer-binding protein. (347 aa) |
| | ENSECAP00000024095 | Uncharacterized protein. (362 aa) |
| | HLA-DOA | Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (262 aa) |
| | DRB | Ig-like domain-containing protein. (275 aa) |
| | LAMP1 | Lysosomal associated membrane protein 1. (608 aa) |
| | ENSECAP00000024650 | Uncharacterized protein. (88 aa) |
| | LAMP2 | Lysosomal associated membrane protein 2. (446 aa) |
| | ENSECAP00000026008 | Ig-like domain-containing protein. (182 aa) |
| | TLR1 | Toll-like receptor. (756 aa) |
| | IFN-ALPHA2 | Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities. (184 aa) |
| | RAB7A | RAB7A, member RAS oncogene family. (229 aa) |
| | WDR92 | Protein phosphatase 3 regulatory subunit B, alpha. (496 aa) |
| | LOC111768185 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa) |
| | KSR1 | Kinase suppressor of ras 1. (761 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa) |
| | LOC100051526 | Uncharacterized protein. (285 aa) |
| | LOC111772122 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (369 aa) |
| | RFXANK | Regulatory factor X associated ankyrin containing protein. (269 aa) |
| | CALML5 | Calmodulin like 5. (149 aa) |
| | PPP3CC | Serine/threonine-protein phosphatase. (534 aa) |
| | STAT1 | Signal transducer and activator of transcription. (749 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (446 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (717 aa) |
| | ATP6V1H | V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa) |
| | DQB | Ig-like domain-containing protein. (309 aa) |
| | LOC100064172 | Uncharacterized protein. (155 aa) |
| | RHOA | Transforming protein RhoA-like protein. (193 aa) |
| | SYK | Tyrosine-protein kinase. (716 aa) |
| | LOC111768487 | Uncharacterized protein. (155 aa) |
| | LOC100053110 | Interferon alpha-4; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (184 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (632 aa) |
| | DRB-2 | Ig-like domain-containing protein. (288 aa) |
| | CTSD | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (536 aa) |
| | RAB5A | RAB5A, member RAS oncogene family. (215 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (421 aa) |
| | LOC100629951 | Interferon alpha-1; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (184 aa) |
| | SPHK1 | Sphingosine kinase 1. (459 aa) |
| | EEA1 | Early endosome antigen 1. (1452 aa) |
| | CAMK2B | Calcium/calmodulin dependent protein kinase II beta. (656 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (805 aa) |
| | ARHGEF12 | Rho guanine nucleotide exchange factor 12. (1544 aa) |
| | CAMK2G | Calcium/calmodulin dependent protein kinase II gamma. (556 aa) |
| | LSP1 | Lymphocyte specific protein 1. (401 aa) |
| | ITGB2 | Integrin beta. (873 aa) |
| | LOC100629885 | Uncharacterized protein. (167 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa) |
| | LOC100064612 | Uncharacterized protein. (171 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | LOC100147174 | Uncharacterized protein. (186 aa) |
| | LOC100060505 | Uncharacterized protein. (1662 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | HLA-DMA | Major histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (314 aa) |
| | LOC100051733 | Uncharacterized protein. (635 aa) |
| | DRB-3 | MHC class II antigen. (266 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (268 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (475 aa) |
| | CIITA | Class II major histocompatibility complex transactivator. (1206 aa) |
| | IFNGR2 | Interferon gamma receptor 2. (461 aa) |
