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| | CREB3 | cAMP responsive element binding protein 3. (390 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa) |
| | IFND2 | Uncharacterized protein. (170 aa) |
| | YWHAQ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (245 aa) |
| | TICAM1 | Toll like receptor adaptor molecule 1. (698 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (464 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (364 aa) |
| | IFNB1 | Interferon beta; Has antiviral, antibacterial and anticancer activities. (186 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (194 aa) |
| | LOC100053210 | Uncharacterized protein. (184 aa) |
| | ATF4 | Activating transcription factor 4. (334 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | CREB3L2 | cAMP responsive element binding protein 3 like 2. (520 aa) |
| | ELK1 | ETS transcription factor ELK1. (432 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | BIRC5 | Baculoviral IAP repeat containing 5. (226 aa) |
| | IFIH1 | Interferon induced with helicase C domain 1. (1026 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | LOC100069290 | Uncharacterized protein; Belongs to the peptidase C14A family. (444 aa) |
| | DDB2 | Damage specific DNA binding protein 2. (427 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase. (528 aa) |
| | STAT6 | Signal transducer and activator of transcription. (847 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (494 aa) |
| | MAP2K2 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | EP300 | E1A binding protein p300. (2430 aa) |
| | JAK2 | Tyrosine-protein kinase. (1131 aa) |
| | TLR4 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa) |
| | IFNAR1 | Interferon alpha and beta receptor subunit 1. (561 aa) |
| | EGR2 | Early growth response 2. (486 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (932 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | TGFB1 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | SRC | Tyrosine-protein kinase. (551 aa) |
| | TIRAP | TIR domain containing adaptor protein. (234 aa) |
| | TICAM2 | TIR domain-containing protein. (238 aa) |
| | DDB1 | Damage specific DNA binding protein 1. (1183 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | MMP9 | Matrix metallopeptidase 9. (714 aa) |
| | FAS | Fas cell surface death receptor. (365 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (551 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (381 aa) |
| | CYCS | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | ATP6AP1 | ATPase H+ transporting accessory protein 1. (467 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | BAD | BCL2 associated agonist of cell death. (167 aa) |
| | SLC10A1 | Solute carrier family 10 member 1. (349 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) |
| | TGFBR2 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (687 aa) |
| | CXCL8 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity). (101 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (1049 aa) |
| | LOC111768755 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (144 aa) |
| | FASLG | Tumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family. (283 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (192 aa) |
| | CREB3L4 | cAMP responsive element binding protein 3 like 4. (393 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (365 aa) |
| | TLR2 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | IRF3 | Interferon regulatory factor 3. (426 aa) |
| | NFATC2 | Nuclear factor of activated T cells 2. (915 aa) |
| | JAK1 | Tyrosine-protein kinase. (1141 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (456 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | YWHAB | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (404 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa) |
| | TYK2 | Tyrosine-protein kinase. (1262 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (212 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (408 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (164 aa) |
| | ATF6B | Activating transcription factor 6 beta. (703 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (442 aa) |
| | DDX58 | DExD/H-box helicase 58. (1021 aa) |
| | CASP3 | Caspase-3-like protein; Belongs to the peptidase C14A family. (277 aa) |
| | STAT2 | Signal transducer and activator of transcription. (847 aa) |
| | NFKBIA | NFKB inhibitor alpha. (543 aa) |
| | STAT4 | Signal transducer and activator of transcription. (748 aa) |
| | E2F1 | E2F transcription factor 1. (436 aa) |
| | E2F2 | E2F transcription factor 2. (549 aa) |
| | JUN | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (340 aa) |
| | ARAF | A-Raf proto-oncogene, serine/threonine kinase. (624 aa) |
| | CASP10 | Caspase 10; Belongs to the peptidase C14A family. (478 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1256 aa) |
| | CREBBP | CREB binding protein. (2442 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4. (531 aa) |
| | PIK3R2 | Uncharacterized protein. (479 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1081 aa) |
| | NFATC1 | Nuclear factor of activated T cells 1. (1067 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (822 aa) |
| | E2F3 | E2F transcription factor 3. (546 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (247 aa) |
| | IFN-ALPHA2 | Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities. (184 aa) |
| | CREB3L1 | cAMP responsive element binding protein 3 like 1. (524 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (654 aa) |
| | BRAF | B-Raf proto-oncogene, serine/threonine kinase. (793 aa) |
| | ATF2 | Activating transcription factor 2. (512 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (770 aa) |
| | LOC100052122 | Uncharacterized protein. (461 aa) |
| | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1. (1672 aa) |
| | TLR3 | Toll like receptor 3; Belongs to the Toll-like receptor family. (979 aa) |
| | NFATC3 | Nuclear factor of activated T cells 3. (1073 aa) |
| | STAT1 | Signal transducer and activator of transcription. (749 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa) |
| | MAP2K3 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (446 aa) |
| | STAT5B | Signal transducer and activator of transcription. (825 aa) |
| | STAT3 | Signal transducer and activator of transcription. (770 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa) |
| | DDX3X | DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (685 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (363 aa) |
| | LOC100053110 | Interferon alpha-4; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (184 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (632 aa) |
| | RB1 | RB transcriptional corepressor 1. (965 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (425 aa) |
| | STAT5A | Signal transducer and activator of transcription. (800 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (421 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa) |
| | JAK3 | Tyrosine-protein kinase. (1139 aa) |
| | LOC100629951 | Interferon alpha-1; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (184 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (805 aa) |
| | MAVS | Mitochondrial antiviral signaling protein. (597 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa) |
| | LOC100629885 | Uncharacterized protein. (167 aa) |
| | EGR3 | Early growth response 3. (387 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa) |
| | LOC100064612 | Uncharacterized protein. (171 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | LOC100147174 | Uncharacterized protein. (186 aa) |
| | CREB3L3 | cAMP responsive element binding protein 3 like 3. (468 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | CREB5 | Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa) |
| | VDAC3 | Voltage dependent anion channel 3. (284 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1613 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | HSPG2 | Heparan sulfate proteoglycan 2. (4395 aa) |
