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| | ELOC | Elongin C; Belongs to the SKP1 family. (112 aa) |
| | GNAI1 | G protein subunit alpha i1. (354 aa) |
| | GNAI2 | G protein subunit alpha i2. (355 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa) |
| | IFND2 | Uncharacterized protein. (170 aa) |
| | BST2 | Uncharacterized protein. (234 aa) |
| | CXCR4 | C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (353 aa) |
| | SKP1 | S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa) |
| | GNG10 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa) |
| | CD3G | CD3g molecule. (178 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (464 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (364 aa) |
| | CALML3 | Calmodulin like 3; Belongs to the calmodulin family. (149 aa) |
| | IFNB1 | Interferon beta; Has antiviral, antibacterial and anticancer activities. (186 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (194 aa) |
| | LOC100053210 | Uncharacterized protein. (184 aa) |
| | TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | GNB4 | G protein subunit beta 4. (340 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | CALR | Calreticulin. (412 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | GNG14 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase. (528 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (525 aa) |
| | CALM1 | Uncharacterized protein; Belongs to the calmodulin family. (336 aa) |
| | CD4 | CD4 molecule. (460 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (494 aa) |
| | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (670 aa) |
| | MAP2K2 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | GNAI3 | G protein subunit alpha i3. (354 aa) |
| | CUL1 | Cullin 1; Belongs to the cullin family. (776 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | TLR4 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa) |
| | AP1S1 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (932 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | CRK | CRK proto-oncogene, adaptor protein. (304 aa) |
| | GNG3 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa) |
| | GNB3 | G protein subunit beta 3. (340 aa) |
| | RPS6KB2 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa) |
| | DDB1 | Damage specific DNA binding protein 1. (1183 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa) |
| | TRADD | TNFRSF1A associated via death domain. (312 aa) |
| | FAS | Fas cell surface death receptor. (365 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (551 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (381 aa) |
| | RPS6KB1 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa) |
| | CYCS | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | BAD | BCL2 associated agonist of cell death. (167 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) |
| | LOC100062428 | Calreticulin. (408 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | AP1G2 | AP-1 complex subunit gamma. (785 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (1049 aa) |
| | TAPBP | TAP binding protein. (446 aa) |
| | F6UE14_HORSE | MHC_I-like_Ag-recog domain-containing protein. (212 aa) |
| | GNGT2 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (86 aa) |
| | CCNB1 | Cyclin B1; Belongs to the cyclin family. (423 aa) |
| | LOC111768755 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (144 aa) |
| | FASLG | Tumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family. (283 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (192 aa) |
| | GNB2 | G protein subunit beta 2. (340 aa) |
| | PAK6 | Non-specific serine/threonine protein kinase. (680 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (365 aa) |
| | TLR2 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | GNG13 | G protein subunit gamma 13. (67 aa) |
| | CD3D | CD3d molecule. (165 aa) |
| | GNAQ | G protein subunit alpha q. (441 aa) |
| | IRF3 | Interferon regulatory factor 3. (426 aa) |
| | PAK1 | Non-specific serine/threonine protein kinase. (544 aa) |
| | NFATC2 | Nuclear factor of activated T cells 2. (915 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | CUL4A | Cullin 4A; Belongs to the cullin family. (764 aa) |
| | CGAS | Cyclic GMP-AMP synthase. (581 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa) |
| | CFL1 | Cofilin 1; Belongs to the actin-binding proteins ADF family. (166 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | CD247 | CD247 molecule. (167 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | PAK2 | Non-specific serine/threonine protein kinase. (524 aa) |
| | PDIA3 | Protein disulfide-isomerase. (505 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa) |
| | WEE1 | Wee1-like protein kinase. (646 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (212 aa) |
| | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa) |
| | CALML4 | Calmodulin like 4. (197 aa) |
| | WEE2 | Wee1-like protein kinase. (566 aa) |
| | CASP3 | Caspase-3-like protein; Belongs to the peptidase C14A family. (277 aa) |
| | NFKBIA | NFKB inhibitor alpha. (543 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (211 aa) |
| | CUL4B | Cullin 4B; Belongs to the cullin family. (920 aa) |
| | JUN | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (340 aa) |
| | GNG11 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | GNG8 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa) |
| | RNF7 | Ring finger protein 7. (187 aa) |
| | AP1M1 | AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (536 aa) |
| | PIK3R2 | Uncharacterized protein. (479 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1081 aa) |
| | NFATC1 | Nuclear factor of activated T cells 1. (1067 aa) |
| | CFL2 | Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa) |
| | ENSECAP00000025114 | Ig-like domain-containing protein; Belongs to the MHC class I family. (455 aa) |
| | STING1 | Transmembrane protein 173. (405 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3076 aa) |
| | PTK2 | Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1093 aa) |
| | LOC111767719 | Ig-like domain-containing protein. (187 aa) |
| | PAK5 | Non-specific serine/threonine protein kinase. (718 aa) |
| | ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa) |
| | LOC111772100 | Ig-like domain-containing protein. (173 aa) |
| | AP1S3 | Adaptor related protein complex 1 subunit sigma 3. (312 aa) |
| | IFN-ALPHA2 | Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities. (184 aa) |
| | BCL2L1 | BCL2 like 1. (245 aa) |
| | GNG4 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (164 aa) |
| | BTRC | Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa) |
| | WDR92 | Protein phosphatase 3 regulatory subunit B, alpha. (496 aa) |
| | CRKL | CRK like proto-oncogene, adaptor protein. (303 aa) |
| | DCAF1 | DDB1 and CUL4 associated factor 1. (1534 aa) |
| | RBX1 | Ring-box 1. (108 aa) |
| | GNGT1 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (654 aa) |
| | EQMHCC1 | Ig-like domain-containing protein; Belongs to the MHC class I family. (445 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (770 aa) |
| | LOC100052122 | Uncharacterized protein. (461 aa) |
| | CD3E | CD3e molecule. (246 aa) |
| | CALML5 | Calmodulin like 5. (149 aa) |
| | GNG5 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (341 aa) |
| | PLCG2 | Phosphoinositide phospholipase C. (1331 aa) |
| | PPP3CC | Serine/threonine-protein phosphatase. (534 aa) |
| | NFATC3 | Nuclear factor of activated T cells 3. (1073 aa) |
| | CDK1 | Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (373 aa) |
| | GNG7 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa) |
| | MAP2K3 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa) |
| | LIMK2 | LIM domain kinase 2. (652 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa) |
| | GNA11 | G protein subunit alpha 11. (528 aa) |
| | AP1B1 | Adaptor related protein complex 1 subunit beta 1. (969 aa) |
| | ELOB | Elongin B. (118 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (446 aa) |
| | RAC1 | Rac family small GTPase 1. (221 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (717 aa) |
| | APOBEC3H | CMP/dCMP-type deaminase domain-containing protein. (316 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa) |
| | AP1S2 | Adaptor related protein complex 1 subunit sigma 2. (243 aa) |
| | RAC2 | Rac family small GTPase 2. (192 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | LOC100069440 | Uncharacterized protein. (298 aa) |
| | LOC100056182 | Uncharacterized protein; Belongs to the MHC class I family. (362 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (363 aa) |
| | LOC100053110 | Interferon alpha-4; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (184 aa) |
| | ITPR3 | Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (632 aa) |
| | GNAO1 | G protein subunit alpha o1. (354 aa) |
| | CCNB3 | Cyclin B3; Belongs to the cyclin family. (1296 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (421 aa) |
| | LIMK1 | LIM domain kinase 1. (789 aa) |
| | LOC100054114 | Ig-like domain-containing protein; Belongs to the MHC class I family. (347 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa) |
| | LOC106783094 | Ig-like domain-containing protein. (229 aa) |
| | LOC100629951 | Interferon alpha-1; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (184 aa) |
| | TAP2 | Uncharacterized protein. (733 aa) |
| | PXN | Paxillin. (1236 aa) |
| | GNB1 | G protein subunit beta 1. (360 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (805 aa) |
| | GNG12 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa) |
| | CUL5 | Cullin 5; Belongs to the cullin family. (780 aa) |
| | AP1M2 | Adaptor related protein complex 1 subunit mu 2; Belongs to the adaptor complexes medium subunit family. (653 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (4382 aa) |
| | LOC100629885 | Uncharacterized protein. (167 aa) |
| | CDC25C | Cell division cycle 25C. (510 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa) |
| | LOC100064612 | Uncharacterized protein. (171 aa) |
| | B2M | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (125 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2573 aa) |
| | LOC100050473 | Ig-like domain-containing protein; Belongs to the MHC class I family. (389 aa) |
| | LOC100147174 | Uncharacterized protein. (186 aa) |
| | GNB5 | G protein subunit beta 5. (395 aa) |
| | GNG2 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (108 aa) |
| | MHCB3 | Ig-like domain-containing protein; Belongs to the MHC class I family. (433 aa) |
| | LOC100059994 | Uncharacterized protein; Belongs to the MHC class I family. (592 aa) |
| | TNFRSF1B | TNF receptor superfamily member 1B. (481 aa) |
| | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (475 aa) |
