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CREB3 CREB3 CCR3 CCR3 H2BC11 H2BC11 H2BC1 H2BC1 PSMC1 PSMC1 REL REL LOC100063835 LOC100063835 GTF2A1 GTF2A1 H2BC3 H2BC3 YWHAQ YWHAQ CCR4 CCR4 DNAJA3 DNAJA3 H2BC12 H2BC12 CASP8 CASP8 H2BU1 H2BU1 UBE3A UBE3A YWHAG YWHAG ATF4 ATF4 LOC102148494 LOC102148494 TRAF5 TRAF5 LOC100054193 LOC100054193 LOC100068321 LOC100068321 PIK3CD PIK3CD CREB3L2 CREB3L2 H2BC18 H2BC18 LOC100073305 LOC100073305 HRAS HRAS TBP TBP SRF SRF YWHAE YWHAE EP300 EP300 EGR2 EGR2 RASA2 RASA2 GTF2A2 GTF2A2 SRC SRC SND1 SND1 CCND2 CCND2 GTF2A1L GTF2A1L DDB1 DDB1 SKP2 SKP2 TRAF2 TRAF2 TRADD TRADD HDAC2 HDAC2 NRAS NRAS RELA RELA RBL2 RBL2 YWHAH YWHAH MAPK3 MAPK3 BAD BAD PIK3CA PIK3CA NFKB1 NFKB1 ATP6V0D2 ATP6V0D2 ATP6V0D1 ATP6V0D1 F6UE14_HORSE F6UE14_HORSE HDAC1 HDAC1 BAX BAX CREB3L4 CREB3L4 GTF2E2 GTF2E2 HDAC8 HDAC8 IRF3 IRF3 CDKN2B CDKN2B JAK1 JAK1 KRAS KRAS CCNA1 CCNA1 CDC20 CDC20 PIK3R1 PIK3R1 YWHAB YWHAB CCNE2 CCNE2 HDAC3 HDAC3 IKBKG IKBKG CCNE1 CCNE1 CDKN1A CDKN1A ATF6B ATF6B HDAC5 HDAC5 MAPKAPK2 MAPKAPK2 CASP3 CASP3 CHD4 CHD4 MRPS18B MRPS18B CDKN1B CDKN1B NFKBIA NFKBIA BAK1 BAK1 JUN JUN RBL1 RBL1 PIK3CB PIK3CB IRF9 IRF9 CREBBP CREBBP GTF2B GTF2B CDK4 CDK4 KAT2A KAT2A PIK3R2 PIK3R2 UBR4 UBR4 ENSECAP00000025114 ENSECAP00000025114 CDC42 CDC42 IL6ST IL6ST HDAC4 HDAC4 YWHAZ YWHAZ HDAC9 HDAC9 SCIN SCIN GSN GSN LOC100053695 LOC100053695 CCND1 CCND1 LOC100068222 LOC100068222 HDAC10 HDAC10 MDM2 MDM2 CREB3L1 CREB3L1 H2BW1 H2BW1 GTF2H4 GTF2H4 EQMHCC1 EQMHCC1 ATF2 ATF2 PRKACA PRKACA EIF2AK2 EIF2AK2 LOC100052122 LOC100052122 LOC100073295 LOC100073295 TBPL1 TBPL1 CDK1 CDK1 KAT2B KAT2B TP53 TP53 SNW1 SNW1 HNRNPK HNRNPK NFKB2 NFKB2 STAT5B STAT5B RAC1 RAC1 STAT3 STAT3 USP7 USP7 DLG1 DLG1 RHOA RHOA DDX3X DDX3X SYK SYK HDAC6 HDAC6 LTBR LTBR LOC100056182 LOC100056182 GTF2H1 GTF2H1 HDAC11 HDAC11 ACTN1 ACTN1 RB1 RB1 HPN HPN PRKACB PRKACB STAT5A STAT5A MAD1L1 MAD1L1 PMAIP1 PMAIP1 GTF2E1 GTF2E1 LOC100054114 LOC100054114 LYN LYN JAK3 JAK3 ACTN4 ACTN4 TRAF3 TRAF3 PXN PXN LOC100052568 LOC100052568 VAC14 VAC14 RBPJL RBPJL LOC100054473 LOC100054473 RBPJ RBPJ TRAF1 TRAF1 CDK6 CDK6 SP100 SP100 EGR3 EGR3 MAPK1 MAPK1 LOC100050473 LOC100050473 LOC100060505 LOC100060505 CREB3L3 CREB3L3 H2BW4 H2BW4 CREB5 CREB5 H2BC5 H2BC5 MHCB3 MHCB3 LOC100059994 LOC100059994 VDAC3 VDAC3 POLB POLB SCRIB SCRIB CCND3 CCND3 GTF2H3 GTF2H3 CDKN2A CDKN2A
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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CREB3cAMP responsive element binding protein 3. (390 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (377 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
RELREL proto-oncogene, NF-kB subunit. (596 aa)
LOC100063835Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
GTF2A1General transcription factor IIA subunit 1. (376 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
YWHAQTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (245 aa)
CCR4C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (434 aa)
DNAJA3DnaJ heat shock protein family (Hsp40) member A3. (529 aa)
H2BC12Histone H2B; Belongs to the histone H2B family. (187 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (464 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (876 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
ATF4Activating transcription factor 4. (334 aa)
LOC102148494Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (104 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
LOC100054193Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC100068321Histone H2B; Belongs to the histone H2B family. (126 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC100073305General transcription factor IIH subunit. (395 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
TBPTATA-box binding protein. (329 aa)
SRFSerum response factor. (512 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (312 aa)
EP300E1A binding protein p300. (2430 aa)
EGR2Early growth response 2. (486 aa)
RASA2RAS p21 protein activator 2. (966 aa)
GTF2A2General transcription factor IIA subunit 2. (140 aa)
SRCTyrosine-protein kinase. (551 aa)
SND1Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (947 aa)
CCND2Cyclin D2; Belongs to the cyclin family. (289 aa)
GTF2A1LUncharacterized protein. (473 aa)
DDB1Damage specific DNA binding protein 1. (1183 aa)
SKP2S-phase kinase associated protein 2. (436 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
TRADDTNFRSF1A associated via death domain. (312 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
RBL2RB transcriptional corepressor like 2. (1140 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
BADBCL2 associated agonist of cell death. (167 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NFKB1Nuclear factor kappa B subunit 1. (1049 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
F6UE14_HORSEMHC_I-like_Ag-recog domain-containing protein. (212 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (393 aa)
GTF2E2General transcription factor IIE subunit 2. (337 aa)
HDAC8Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (484 aa)
IRF3Interferon regulatory factor 3. (426 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
JAK1Tyrosine-protein kinase. (1141 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (456 aa)
CDC20Cell division cycle 20. (499 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (506 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (408 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ATF6BActivating transcription factor 6 beta. (703 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1117 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CASP3Caspase-3-like protein; Belongs to the peptidase C14A family. (277 aa)
CHD4Chromodomain helicase DNA binding protein 4. (1912 aa)
MRPS18BMitochondrial ribosomal protein S18B. (258 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
NFKBIANFKB inhibitor alpha. (543 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (340 aa)
RBL1RB transcriptional corepressor like 1. (1068 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
IRF9Interferon regulatory factor 9. (394 aa)
CREBBPCREB binding protein. (2442 aa)
GTF2BTranscription initiation factor IIB-like protein. (316 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
PIK3R2Uncharacterized protein. (479 aa)
UBR4Ubiquitin protein ligase E3 component n-recognin 4. (5192 aa)
ENSECAP00000025114Ig-like domain-containing protein; Belongs to the MHC class I family. (455 aa)
CDC42Cell division control protein 42-like protein. (191 aa)
IL6STInterleukin 6 signal transducer. (1023 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1170 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (247 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1162 aa)
SCINScinderin. (735 aa)
GSNGelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis (By similarity). (871 aa)
LOC100053695Histone H2B; Belongs to the histone H2B family. (126 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
LOC100068222Histone H2B; Belongs to the histone H2B family. (126 aa)
HDAC10Histone deacetylase 10. (716 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (491 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (524 aa)
H2BW1Histone domain-containing protein; Belongs to the histone H2B family. (168 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (463 aa)
EQMHCC1Ig-like domain-containing protein; Belongs to the MHC class I family. (445 aa)
ATF2Activating transcription factor 2. (512 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (359 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (540 aa)
LOC100052122Uncharacterized protein. (461 aa)
LOC100073295Histone domain-containing protein; Belongs to the histone H2B family. (122 aa)
TBPL1TATA-box binding protein like 1. (217 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (373 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (824 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa)
SNW1SNW domain containing 1. (540 aa)
HNRNPKHeterogeneous nuclear ribonucleoprotein K. (464 aa)
NFKB2Nuclear factor kappa B subunit 2. (1024 aa)
STAT5BSignal transducer and activator of transcription. (825 aa)
RAC1Rac family small GTPase 1. (221 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1140 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (938 aa)
RHOATransforming protein RhoA-like protein. (193 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (685 aa)
SYKTyrosine-protein kinase. (716 aa)
HDAC6Histone deacetylase 6. (1266 aa)
LTBRLymphotoxin beta receptor. (434 aa)
LOC100056182Uncharacterized protein; Belongs to the MHC class I family. (362 aa)
GTF2H1General transcription factor IIH subunit 1. (594 aa)
HDAC11Histone deacetylase 11. (349 aa)
ACTN1Actinin alpha 1. (959 aa)
RB1RB transcriptional corepressor 1. (965 aa)
HPNHepsin; Belongs to the peptidase S1 family. (513 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
STAT5ASignal transducer and activator of transcription. (800 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (754 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
GTF2E1General transcription factor IIE subunit 1. (524 aa)
LOC100054114Ig-like domain-containing protein; Belongs to the MHC class I family. (347 aa)
LYNTyrosine-protein kinase. (533 aa)
JAK3Tyrosine-protein kinase. (1139 aa)
ACTN4Actinin alpha 4. (933 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
PXNPaxillin. (1236 aa)
LOC100052568Histone H2B; Belongs to the histone H2B family. (126 aa)
VAC14VAC14 component of PIKFYVE complex. (809 aa)
RBPJLRecombination signal binding protein for immunoglobulin kappa J region like. (517 aa)
LOC100054473Histone H2B; Belongs to the histone H2B family. (126 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
TRAF1TNF receptor-associated factor. (415 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (403 aa)
SP100SP100 nuclear antigen. (872 aa)
EGR3Early growth response 3. (387 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa)
LOC100050473Ig-like domain-containing protein; Belongs to the MHC class I family. (389 aa)
LOC100060505Uncharacterized protein. (1662 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (468 aa)
H2BW4Histone domain-containing protein; Belongs to the histone H2B family. (170 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
MHCB3Ig-like domain-containing protein; Belongs to the MHC class I family. (433 aa)
LOC100059994Uncharacterized protein; Belongs to the MHC class I family. (592 aa)
VDAC3Voltage dependent anion channel 3. (284 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
SCRIBScribble planar cell polarity protein. (1690 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
GTF2H3General transcription factor IIH subunit 3. (309 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (214 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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