(65 nodes) Chemical carcinogenesis network (Equus caballus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100061367	Uncharacterized protein; Belongs to the cytochrome P450 family. (495 aa)
	LOC100049837	Uncharacterized protein; Belongs to the arylamine N-acetyltransferase family. (290 aa)
	LOC100050322	Uncharacterized protein; Belongs to the GST superfamily. (240 aa)
	ALDH3B2	Aldehyde dehydrogenase 3 family member B2; Belongs to the aldehyde dehydrogenase family. (380 aa)
	CYP2C92	Uncharacterized protein; Belongs to the cytochrome P450 family. (491 aa)
	LOC100052993	Sulfotransferase; Belongs to the sulfotransferase 1 family. (286 aa)
	CYP2B6	Cytochrome P450 family 2 subfamily B member 6; Belongs to the cytochrome P450 family. (508 aa)
	LOC111775200	Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
	CYP1A2	Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (516 aa)
	LOC100146977	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
	CYP2A13	Uncharacterized protein; Belongs to the cytochrome P450 family. (529 aa)
	ARNT	Aryl hydrocarbon receptor nuclear translocator. (790 aa)
	ALDH3A1	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (470 aa)
	LOC100061542	Uncharacterized protein; Belongs to the cytochrome P450 family. (532 aa)
	LOC100068569	Uncharacterized protein; Belongs to the cytochrome P450 family. (578 aa)
	CYP1A1	Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (524 aa)
	CYP3A94	Uncharacterized protein. (504 aa)
	F6WNE2_HORSE	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa)
	PTGS2	Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (666 aa)
	LOC100068026	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
	LOC100066329	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa)
	HSD11B1	Hydroxysteroid 11-beta dehydrogenase 1. (296 aa)
	GSTM3	Glutathione S-transferase. (225 aa)
	CYP1B1	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (560 aa)
	SRP9	Epoxide hydrolase 1. (491 aa)
	LOC100059533	Uncharacterized protein. (210 aa)
	GSTP1	Glutathione S-transferase pi 1. (210 aa)
	MGST1	Microsomal glutathione S-transferase 1-like protein. (155 aa)
	LOC100050329	Sulfotransferase; Belongs to the sulfotransferase 1 family. (285 aa)
	LOC100064221	Sulfotransferase; Belongs to the sulfotransferase 1 family. (295 aa)
	LOC100630657	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (296 aa)
	KYAT1	Kynurenine aminotransferase 1. (424 aa)
	LOC100146413	Uncharacterized protein. (526 aa)
	LOC100058329	Glutathione S-transferase. (218 aa)
	LOC100070400	Uncharacterized protein; Belongs to the cytochrome P450 family. (536 aa)
	LOC100058290	Uncharacterized protein; Belongs to the GST superfamily. (432 aa)
	LOC100060521	Uncharacterized protein. (510 aa)
	ENSECAP00000024986	Uncharacterized protein. (141 aa)
	UGT1A1	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (533 aa)
	GSTA4	Glutathione S-transferase alpha 4; Belongs to the GST superfamily. (256 aa)
	ADH5	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (372 aa)
	ALDH3B1	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (498 aa)
	CYP3A93	Uncharacterized protein. (768 aa)
	CYP3A89	Uncharacterized protein. (925 aa)
	LOC100067994	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
	KYAT3	Kynurenine aminotransferase 3. (511 aa)
	LOC100034175	Alcohol dehydrogenase S chain. (424 aa)
	HPGDS	Hematopoietic prostaglandin D synthase. (225 aa)
	LOC111772843	Uncharacterized protein. (375 aa)
	LOC100034242	Alcohol dehydrogenase E chain. (426 aa)
	LOC100066501	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa)
	LOC100061690	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (296 aa)
	CYP2C113	Cytochrome P450 2C113; Belongs to the cytochrome P450 family. (490 aa)
	LOC100050266	Sulfotransferase; Belongs to the sulfotransferase 1 family. (284 aa)
	LOC100061609	Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa)
	LOC111772842	PKS_ER domain-containing protein. (380 aa)
	LOC100061502	Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa)
	MGST2	Microsomal glutathione S-transferase 2. (224 aa)
	LOC100061400	Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa)
	LOC111772845	PKS_ER domain-containing protein. (391 aa)
	GSTK1	Glutathione S-transferase kappa 1. (353 aa)
	UGT2A1	UDP glucuronosyltransferase family 2 member A1 complex locus; Belongs to the UDP-glycosyltransferase family. (704 aa)
	LOC100068041	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (329 aa)
	LOC100066444	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
	GSTT4	Glutathione S-transferase theta 4. (245 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADH5	ALDH3A1	ENSECAP00000027421	ENSECAP00000008456	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.932
ADH5	ALDH3B1	ENSECAP00000027421	ENSECAP00000027431	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.933
ADH5	ALDH3B2	ENSECAP00000027421	ENSECAP00000002891	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Aldehyde dehydrogenase 3 family member B2; Belongs to the aldehyde dehydrogenase family.	0.933
ADH5	F6WNE2_HORSE	ENSECAP00000027421	ENSECAP00000014848	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.690
ADH5	GSTA4	ENSECAP00000027421	ENSECAP00000025356	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Glutathione S-transferase alpha 4; Belongs to the GST superfamily.	0.711
ADH5	GSTK1	ENSECAP00000027421	ENSECAP00000044213	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Glutathione S-transferase kappa 1.	0.704
ADH5	GSTM3	ENSECAP00000027421	ENSECAP00000016893	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Glutathione S-transferase.	0.743
ADH5	GSTP1	ENSECAP00000027421	ENSECAP00000018076	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Glutathione S-transferase pi 1.	0.684
ADH5	GSTT4	ENSECAP00000027421	ENSECAP00000050527	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Glutathione S-transferase theta 4.	0.677
ADH5	HPGDS	ENSECAP00000027421	ENSECAP00000033423	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Hematopoietic prostaglandin D synthase.	0.747
ADH5	LOC100050322	ENSECAP00000027421	ENSECAP00000002027	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Uncharacterized protein; Belongs to the GST superfamily.	0.677
ADH5	LOC100058290	ENSECAP00000027421	ENSECAP00000022530	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Uncharacterized protein; Belongs to the GST superfamily.	0.667
ADH5	LOC100058329	ENSECAP00000027421	ENSECAP00000021933	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Glutathione S-transferase.	0.689
ADH5	LOC100059533	ENSECAP00000027421	ENSECAP00000017624	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Uncharacterized protein.	0.684
ADH5	LOC100066329	ENSECAP00000027421	ENSECAP00000015693	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.690
ADH5	LOC100066444	ENSECAP00000027421	ENSECAP00000049914	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.690
ADH5	LOC100066501	ENSECAP00000027421	ENSECAP00000034296	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.690
ADH5	LOC100067994	ENSECAP00000027421	ENSECAP00000029191	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.672
ADH5	LOC100068026	ENSECAP00000027421	ENSECAP00000015363	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.672
ADH5	LOC100068041	ENSECAP00000027421	ENSECAP00000049521	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.672