STRINGSTRING
PIK3CD PIK3CD MAPK8 MAPK8 DDB2 DDB2 AKT2 AKT2 VEGFA VEGFA TGFA TGFA MAP2K1 MAP2K1 EGF EGF TGFB1 TGFB1 ARHGEF6 ARHGEF6 RPS6KB2 RPS6KB2 RELA RELA RPS6KB1 RPS6KB1 RALB RALB MAPK3 MAPK3 BAD BAD PLD2 PLD2 POLK POLK TGFBR2 TGFBR2 PIK3CA PIK3CA NFKB1 NFKB1 BRCA2 BRCA2 BAX BAX RALA RALA RAD51 RAD51 JAK1 JAK1 KRAS KRAS AKT3 AKT3 PIK3R1 PIK3R1 IKBKG IKBKG CDKN1A CDKN1A RALGDS RALGDS GADD45G GADD45G E2F1 E2F1 BAK1 BAK1 E2F2 E2F2 ARAF ARAF PIK3CB PIK3CB CDK4 CDK4 PIK3R2 PIK3R2 LOC100056032 LOC100056032 E2F3 E2F3 SMAD4 SMAD4 CDC42 CDC42 GADD45A GADD45A BCL2L1 BCL2L1 CCND1 CCND1 ERBB2 ERBB2 BRAF BRAF SMAD2 SMAD2 IKBKB IKBKB LOC100052122 LOC100052122 STAT1 STAT1 TP53 TP53 AKT1 AKT1 MAPK9 MAPK9 EGFR EGFR RAC1 RAC1 STAT3 STAT3 LOC102149416 LOC102149416 RAC2 RAC2 CHUK CHUK GADD45B GADD45B CASP9 CASP9 RB1 RB1 SMAD3 SMAD3 PLD1 PLD1 TGFBR1 TGFBR1 CDK6 CDK6 LOC102150685 LOC102150685 MAPK1 MAPK1 MAPK10 MAPK10 MTOR MTOR LOC106780978 LOC106780978 TGFB2 TGFB2 LOC102148588 LOC102148588 RAF1 RAF1 CDKN2A CDKN2A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
AKT2Non-specific serine/threonine protein kinase. (528 aa)
VEGFAVascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (448 aa)
TGFATransforming growth factor alpha. (221 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1209 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (776 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
RALBRAS like proto-oncogene B. (206 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
BADBCL2 associated agonist of cell death. (167 aa)
PLD2Phospholipase. (933 aa)
POLKDNA polymerase kappa. (860 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (687 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NFKB1Nuclear factor kappa B subunit 1. (1049 aa)
BRCA2BRCA2 DNA repair associated. (3442 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
RALARAS like proto-oncogene A. (227 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
JAK1Tyrosine-protein kinase. (1141 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
RALGDSUncharacterized protein. (916 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
E2F1E2F transcription factor 1. (436 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
E2F2E2F transcription factor 2. (549 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (624 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
PIK3R2Uncharacterized protein. (479 aa)
LOC100056032Ras-GEF domain-containing protein. (645 aa)
E2F3E2F transcription factor 3. (546 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
CDC42Cell division control protein 42-like protein. (191 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
BCL2L1BCL2 like 1. (245 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (793 aa)
SMAD2Mothers against decapentaplegic homolog. (610 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (770 aa)
LOC100052122Uncharacterized protein. (461 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
MAPK9Mitogen-activated protein kinase. (446 aa)
EGFRReceptor protein-tyrosine kinase. (1195 aa)
RAC1Rac family small GTPase 1. (221 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
LOC102149416Ras-GEF domain-containing protein. (622 aa)
RAC2Rac family small GTPase 2. (192 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (274 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (632 aa)
RB1RB transcriptional corepressor 1. (965 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
PLD1Phospholipase. (1189 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (403 aa)
LOC102150685Ras-GEF domain-containing protein. (571 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2573 aa)
LOC106780978Ras-GEF domain-containing protein. (703 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
LOC102148588Ras-GEF domain-containing protein. (438 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (214 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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