STRINGSTRING
PTCH1 PTCH1 PTCH2 PTCH2 FZD10 FZD10 DVL2 DVL2 WNT2B WNT2B WNT16 WNT16 CTNNB1 CTNNB1 DDB2 DDB2 WNT5A WNT5A WNT1 WNT1 DVL3 DVL3 GLI1 GLI1 WNT6 WNT6 WNT7B WNT7B FZD6 FZD6 WNT8A WNT8A POLK POLK BAX BAX WNT5B WNT5B FZD2 FZD2 BMP4 BMP4 AXIN2 AXIN2 FZD3 FZD3 WNT4 WNT4 SUFU SUFU DVL1 DVL1 BMP2 BMP2 CDKN1A CDKN1A WNT3 WNT3 WNT11 WNT11 SHH SHH GADD45G GADD45G AXIN1 AXIN1 BAK1 BAK1 HHIP HHIP WNT2 WNT2 GSK3B GSK3B WNT3A WNT3A WNT10A WNT10A TCF7L2 TCF7L2 GADD45A GADD45A FZD5 FZD5 WNT8B WNT8B SMO SMO WNT7A WNT7A APC2 APC2 TP53 TP53 WNT10B WNT10B TCF7L1 TCF7L1 KIF7 KIF7 APC APC WNT9B WNT9B LEF1 LEF1 GADD45B GADD45B WNT9A WNT9A GLI2 GLI2 FZD7 FZD7 FZD4 FZD4 GLI3 GLI3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTCH1Patched 1. (1490 aa)
PTCH2Patched 2. (1207 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
DVL2Dishevelled segment polarity protein 2. (737 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (495 aa)
CTNNB1Beta catenin 1. (781 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
DVL3Dishevelled segment polarity protein 3. (716 aa)
GLI1GLI family zinc finger 1. (1106 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
POLKDNA polymerase kappa. (860 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
AXIN2Axin 2. (843 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
SUFUSUFU negative regulator of hedgehog signaling. (566 aa)
DVL1Dishevelled segment polarity protein 1. (700 aa)
BMP2Bone morphogenetic protein 2. (397 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (475 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
AXIN1Axin 1. (939 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
HHIPHedgehog interacting protein. (700 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (440 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
TCF7L2Transcription factor 7 like 2. (669 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (577 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (379 aa)
APC2APC regulator of WNT signaling pathway 2. (2301 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
TCF7L1Transcription factor 7 like 1. (758 aa)
KIF7Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1364 aa)
APCAPC regulator of WNT signaling pathway. (2873 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
LEF1Lymphoid enhancer binding factor 1. (413 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (274 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
GLI2GLI family zinc finger 2. (1565 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
GLI3GLI family zinc finger 3. (1581 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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