STRINGSTRING
PIK3CD PIK3CD HRAS HRAS DDB2 DDB2 AKT2 AKT2 MAP2K2 MAP2K2 TGFA TGFA MAP2K1 MAP2K1 MET MET EGF EGF HGF HGF RASSF1 RASSF1 NRAS NRAS MAPK3 MAPK3 BAD BAD POLK POLK PIK3CA PIK3CA BAX BAX RARB RARB KRAS KRAS PRKCG PRKCG AKT3 AKT3 PIK3R1 PIK3R1 CDKN1A CDKN1A PLCG1 PLCG1 RXRB RXRB GADD45G GADD45G E2F1 E2F1 BAK1 BAK1 E2F2 E2F2 ARAF ARAF PIK3CB PIK3CB RXRG RXRG FOXO3 FOXO3 CDK4 CDK4 PIK3R2 PIK3R2 E2F3 E2F3 GADD45A GADD45A CCND1 CCND1 ERBB2 ERBB2 BRAF BRAF STK4 STK4 LOC100052122 LOC100052122 PLCG2 PLCG2 TP53 TP53 AKT1 AKT1 EML4 EML4 STAT5B STAT5B EGFR EGFR STAT3 STAT3 PRKCA PRKCA GADD45B GADD45B CASP9 CASP9 RB1 RB1 STAT5A STAT5A RXRA RXRA PRKCB PRKCB JAK3 JAK3 PDPK1 PDPK1 SOS2 SOS2 CDK6 CDK6 MAPK1 MAPK1 RASSF5 RASSF5 FHIT FHIT SOS1 SOS1 RAF1 RAF1 CDKN2A CDKN2A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
AKT2Non-specific serine/threonine protein kinase. (528 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
TGFATransforming growth factor alpha. (221 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1412 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1209 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
RASSF1Ras association domain family member 1. (344 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
BADBCL2 associated agonist of cell death. (167 aa)
POLKDNA polymerase kappa. (860 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
RARBRetinoic acid receptor beta. (448 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
RXRBRetinoid X receptor beta. (536 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
E2F1E2F transcription factor 1. (436 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
E2F2E2F transcription factor 2. (549 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (624 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
RXRGRetinoid X receptor gamma. (463 aa)
FOXO3Forkhead box O3. (671 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
PIK3R2Uncharacterized protein. (479 aa)
E2F3E2F transcription factor 3. (546 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (793 aa)
STK4Serine/threonine kinase 4. (493 aa)
LOC100052122Uncharacterized protein. (461 aa)
PLCG2Phosphoinositide phospholipase C. (1331 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
EML4EMAP like 4. (1006 aa)
STAT5BSignal transducer and activator of transcription. (825 aa)
EGFRReceptor protein-tyrosine kinase. (1195 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (274 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (632 aa)
RB1RB transcriptional corepressor 1. (965 aa)
STAT5ASignal transducer and activator of transcription. (800 aa)
RXRARetinoid X receptor alpha. (677 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
JAK3Tyrosine-protein kinase. (1139 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (585 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (403 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa)
RASSF5Ras association domain family member 5. (422 aa)
FHITBis(5'-adenosyl)-triphosphatase. (149 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1613 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (214 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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