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| | FZD10 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa) |
| | DVL2 | Dishevelled segment polarity protein 2. (737 aa) |
| | SHC1 | SHC adaptor protein 1. (584 aa) |
| | WNT2B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa) |
| | WNT16 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (495 aa) |
| | CTNNB1 | Beta catenin 1. (781 aa) |
| | DLL3 | Delta like canonical Notch ligand 3. (619 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | LRP6 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | DDB2 | Damage specific DNA binding protein 2. (427 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase. (528 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) |
| | DVL3 | Dishevelled segment polarity protein 3. (716 aa) |
| | SHC2 | SHC adaptor protein 2. (579 aa) |
| | MAP2K2 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | FGF21 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1209 aa) |
| | PGR | Progesterone receptor. (934 aa) |
| | RPS6KB2 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa) |
| | NOTCH4 | Notch receptor 4. (2021 aa) |
| | WNT6 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | DLL4 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa) |
| | KIT | KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1084 aa) |
| | WNT7B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) |
| | JAG1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (381 aa) |
| | RPS6KB1 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa) |
| | DLL1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa) |
| | FGF2 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa) |
| | FZD6 | Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa) |
| | WNT8A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) |
| | SHC4 | SHC adaptor protein 4. (630 aa) |
| | POLK | DNA polymerase kappa. (860 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | FGF7 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa) |
| | FGF5 | Fibroblast growth factor 5. (280 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3442 aa) |
| | TNFSF11 | Tumor necrosis factor ligand superfamily member. (318 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (192 aa) |
| | WNT5B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa) |
| | PTEN | Phosphatase and tensin homolog. (576 aa) |
| | FZD2 | Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa) |
| | AXIN2 | Axin 2. (843 aa) |
| | FZD3 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa) |
| | FGF9 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | WNT4 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | FGF1 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa) |
| | DVL1 | Dishevelled segment polarity protein 1. (700 aa) |
| | FGF23 | Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (244 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (164 aa) |
| | WNT3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (475 aa) |
| | NOTCH3 | Notch receptor 3. (2458 aa) |
| | IGF1R | Tyrosine-protein kinase receptor. (1367 aa) |
| | FGF6 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (442 aa) |
| | WNT11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa) |
| | ESR1 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (608 aa) |
| | NOTCH1 | Notch receptor 1. (2581 aa) |
| | GADD45G | Growth arrest and DNA damage inducible gamma. (159 aa) |
| | AXIN1 | Axin 1. (939 aa) |
| | E2F1 | E2F transcription factor 1. (436 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (211 aa) |
| | E2F2 | E2F transcription factor 2. (549 aa) |
| | JUN | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (340 aa) |
| | ARAF | A-Raf proto-oncogene, serine/threonine kinase. (624 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | FGF17 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (240 aa) |
| | WNT2 | Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (440 aa) |
| | ESR2 | Estrogen receptor 2. (550 aa) |
| | CDK4 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa) |
| | FLT4 | Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1366 aa) |
| | HES1 | Hes family bHLH transcription factor 1. (280 aa) |
| | PIK3R2 | Uncharacterized protein. (479 aa) |
| | HEY2 | Hes related family bHLH transcription factor with YRPW motif 2. (337 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa) |
| | FGF19 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa) |
| | WNT10A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa) |
| | TCF7L2 | Transcription factor 7 like 2. (669 aa) |
| | E2F3 | E2F transcription factor 3. (546 aa) |
| | HES5 | Hes family bHLH transcription factor 5. (164 aa) |
| | GADD45A | Growth arrest and DNA damage inducible alpha. (165 aa) |
| | FZD5 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (577 aa) |
| | HEY1 | Hes related family bHLH transcription factor with YRPW motif 1. (304 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | FGF18 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | ERBB2 | Receptor protein-tyrosine kinase. (1255 aa) |
| | WNT8B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa) |
| | WNT7A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (379 aa) |
| | BRAF | B-Raf proto-oncogene, serine/threonine kinase. (793 aa) |
| | FGF16 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | FGF22 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (172 aa) |
| | FRAT1 | Uncharacterized protein. (278 aa) |
| | LOC100052122 | Uncharacterized protein. (461 aa) |
| | APC2 | APC regulator of WNT signaling pathway 2. (2301 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa) |
| | WNT10B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa) |
| | IGF1 | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa) |
| | TCF7L1 | Transcription factor 7 like 1. (758 aa) |
| | NFKB2 | Nuclear factor kappa B subunit 2. (1024 aa) |
| | BRCA1 | BRCA1 DNA repair associated. (1896 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1195 aa) |
| | APC | APC regulator of WNT signaling pathway. (2873 aa) |
| | WNT9B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa) |
| | LRP5 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa) |
| | LEF1 | Lymphoid enhancer binding factor 1. (413 aa) |
| | GADD45B | Growth arrest and DNA damage inducible beta. (274 aa) |
| | NCOA1 | Nuclear receptor coactivator. (1442 aa) |
| | WNT9A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | SP1 | Sp1 transcription factor. (787 aa) |
| | FGF20 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa) |
| | RB1 | RB transcriptional corepressor 1. (965 aa) |
| | FGF4 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa) |
| | FGF3 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (231 aa) |
| | JAG2 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1240 aa) |
| | FRAT2 | FRAT regulator of WNT signaling pathway 2. (233 aa) |
| | HEYL | Hes related family bHLH transcription factor with YRPW motif like. (493 aa) |
| | CSNK1A1 | Casein kinase 1 alpha 1; Belongs to the protein kinase superfamily. (380 aa) |
| | FZD7 | Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa) |
| | NCOA3 | Nuclear receptor coactivator. (1427 aa) |
| | FZD4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa) |
| | NOTCH2 | Notch receptor 2. (2471 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) |
| | CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (403 aa) |
| | FGFR1 | Fibroblast growth factor receptor. (877 aa) |
| | SHC3 | SHC adaptor protein 3. (591 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2573 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1613 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
