STRINGSTRING
MYD88 MYD88 TICAM1 TICAM1 CD3G CD3G MAPK11 MAPK11 PIK3CD PIK3CD HRAS HRAS AKT2 AKT2 PPP3CB PPP3CB MAP3K3 MAP3K3 CD4 CD4 IFNGR1 IFNGR1 MAP2K2 MAP2K2 JAK2 JAK2 TLR4 TLR4 RASGRP1 RASGRP1 BATF3 BATF3 MAP2K1 MAP2K1 EGF EGF ZAP70 ZAP70 TIRAP TIRAP RPS6KB2 RPS6KB2 TICAM2 TICAM2 NRAS NRAS RELA RELA FOS FOS TLR9 TLR9 CSNK2A2 CSNK2A2 RPS6KB1 RPS6KB1 MAPK3 MAPK3 MAPK14 MAPK14 PIK3CA PIK3CA NFKB1 NFKB1 BATF BATF PTEN PTEN MAPK12 MAPK12 TLR2 TLR2 CD3D CD3D NFATC2 NFATC2 JAK1 JAK1 KRAS KRAS NFKBIE NFKBIE AKT3 AKT3 CD247 CD247 PIK3R1 PIK3R1 IKBKG IKBKG TRAF6 TRAF6 CSNK2B CSNK2B LAT LAT PLCG1 PLCG1 LCK LCK NFKBIA NFKBIA JUN JUN PIK3CB PIK3CB PTPN11 PTPN11 PIK3R2 PIK3R2 NFATC1 NFATC1 LOC111767719 LOC111767719 LOC111772100 LOC111772100 WDR92 WDR92 IKBKB IKBKB IFNG IFNG LOC100052122 LOC100052122 CD3E CD3E PPP3CC PPP3CC NFATC3 NFATC3 STAT1 STAT1 MAP2K3 MAP2K3 AKT1 AKT1 EML4 EML4 PRKCQ PRKCQ EGFR EGFR PPP3CA PPP3CA STAT3 STAT3 CHUK CHUK MAP2K6 MAP2K6 MAPK13 MAPK13 CD274 CD274 LOC106783094 LOC106783094 BATF2 BATF2 CSNK2A1 CSNK2A1 CD28 CD28 MAPK1 MAPK1 HIF1A HIF1A NFKBIB NFKBIB MTOR MTOR PTPN6 PTPN6 RAF1 RAF1 IFNGR2 IFNGR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
TICAM1Toll like receptor adaptor molecule 1. (698 aa)
CD3GCD3g molecule. (178 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
AKT2Non-specific serine/threonine protein kinase. (528 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (657 aa)
CD4CD4 molecule. (460 aa)
IFNGR1Interferon gamma receptor 1. (472 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa)
RASGRP1RAS guanyl releasing protein 1. (797 aa)
BATF3Basic leucine zipper ATF-like transcription factor 3. (253 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1209 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
TIRAPTIR domain containing adaptor protein. (234 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa)
TICAM2TIR domain-containing protein. (238 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (350 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NFKB1Nuclear factor kappa B subunit 1. (1049 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
PTENPhosphatase and tensin homolog. (576 aa)
MAPK12Mitogen-activated protein kinase. (365 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
CD3DCD3d molecule. (165 aa)
NFATC2Nuclear factor of activated T cells 2. (915 aa)
JAK1Tyrosine-protein kinase. (1141 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
NFKBIENFKB inhibitor epsilon. (362 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CD247CD247 molecule. (167 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (235 aa)
LATLinker for activation of T cells. (238 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
LCKTyrosine-protein kinase. (509 aa)
NFKBIANFKB inhibitor alpha. (543 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (340 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (606 aa)
PIK3R2Uncharacterized protein. (479 aa)
NFATC1Nuclear factor of activated T cells 1. (1067 aa)
LOC111767719Ig-like domain-containing protein. (187 aa)
LOC111772100Ig-like domain-containing protein. (173 aa)
WDR92Protein phosphatase 3 regulatory subunit B, alpha. (496 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (770 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
LOC100052122Uncharacterized protein. (461 aa)
CD3ECD3e molecule. (246 aa)
PPP3CCSerine/threonine-protein phosphatase. (534 aa)
NFATC3Nuclear factor of activated T cells 3. (1073 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
EML4EMAP like 4. (1006 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (811 aa)
EGFRReceptor protein-tyrosine kinase. (1195 aa)
PPP3CASerine/threonine-protein phosphatase. (717 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (363 aa)
MAPK13Mitogen-activated protein kinase. (421 aa)
CD274CD274 molecule. (301 aa)
LOC106783094Ig-like domain-containing protein. (229 aa)
BATF2Basic leucine zipper ATF-like transcription factor 2. (272 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (464 aa)
CD28CD28 molecule. (228 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (844 aa)
NFKBIBNFKB inhibitor beta. (371 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2573 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
IFNGR2Interferon gamma receptor 2. (461 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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