Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CD28 | CD40 | ENSECAP00000047018 | ENSECAP00000014907 | CD28 molecule. | Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). | 0.575 |
| CD28 | CD40LG | ENSECAP00000047018 | ENSECAP00000050128 | CD28 molecule. | CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. | 0.773 |
| CD28 | CD80 | ENSECAP00000047018 | ENSECAP00000033208 | CD28 molecule. | CD80 molecule. | 0.998 |
| CD28 | CD86 | ENSECAP00000047018 | ENSECAP00000040346 | CD28 molecule. | CD86 molecule. | 0.996 |
| CD28 | CTLA4 | ENSECAP00000047018 | ENSECAP00000002814 | CD28 molecule. | Cytotoxic T-lymphocyte associated protein 4. | 0.665 |
| CD28 | IL10 | ENSECAP00000047018 | ENSECAP00000007097 | CD28 molecule. | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | 0.577 |
| CD28 | IL2 | ENSECAP00000047018 | ENSECAP00000013353 | CD28 molecule. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. | 0.790 |
| CD28 | IL4 | ENSECAP00000047018 | ENSECAP00000006431 | CD28 molecule. | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] | 0.603 |
| CD28 | LOC100049805 | ENSECAP00000047018 | ENSECAP00000047892 | CD28 molecule. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.411 |
| CD28 | LOC100050711 | ENSECAP00000047018 | ENSECAP00000052841 | CD28 molecule. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.457 |
| CD28 | LOC100055651 | ENSECAP00000047018 | ENSECAP00000051796 | CD28 molecule. | Peptidase S1 domain-containing protein. | 0.411 |
| CD28 | LOC111767413 | ENSECAP00000047018 | ENSECAP00000053464 | CD28 molecule. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.457 |
| CD28 | LOC111768663 | ENSECAP00000047018 | ENSECAP00000000569 | CD28 molecule. | Peptidase S1 domain-containing protein. | 0.405 |
| CD40 | CD28 | ENSECAP00000014907 | ENSECAP00000047018 | Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). | CD28 molecule. | 0.575 |
| CD40 | CD40LG | ENSECAP00000014907 | ENSECAP00000050128 | Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). | CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. | 0.999 |
| CD40 | CD80 | ENSECAP00000014907 | ENSECAP00000033208 | Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). | CD80 molecule. | 0.976 |
| CD40 | CD86 | ENSECAP00000014907 | ENSECAP00000040346 | Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). | CD86 molecule. | 0.976 |
| CD40 | CTLA4 | ENSECAP00000014907 | ENSECAP00000002814 | Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). | Cytotoxic T-lymphocyte associated protein 4. | 0.894 |
| CD40 | FAS | ENSECAP00000014907 | ENSECAP00000011600 | Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). | Fas cell surface death receptor. | 0.429 |
| CD40 | FASLG | ENSECAP00000014907 | ENSECAP00000014197 | Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). | Tumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family. | 0.669 |
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