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GJA1 GJA1 CACNG4 CACNG4 CACNG5 CACNG5 CTNNB1 CTNNB1 ATP2A2 ATP2A2 DSC2 DSC2 ITGA9 ITGA9 CTNNA3 CTNNA3 SLC8A2 SLC8A2 CACNG1 CACNG1 RYR2 RYR2 DAG1 DAG1 CDH2 CDH2 ACTN2 ACTN2 ITGA4 ITGA4 ITGB4 ITGB4 LMNA LMNA CD63 CD63 CACNB3 CACNB3 CACNG7 CACNG7 DSG2 DSG2 ITGB7 ITGB7 EMD EMD ITGA8 ITGA8 CACNA2D3 CACNA2D3 ACTB ACTB CACNG3 CACNG3 CACNA1F CACNA1F CACNG2 CACNG2 PELO PELO CACNA1D CACNA1D ITGB3 ITGB3 ITGB8 ITGB8 ACTN3 ACTN3 SGCB SGCB CACNA1S CACNA1S ITGA2B ITGA2B SGCG SGCG CACNA1C CACNA1C ITGB6 ITGB6 CTNNA1 CTNNA1 ITGA2 ITGA2 LAMA2 LAMA2 DSP DSP PKP2 PKP2 TCF7L2 TCF7L2 ATP2A3 ATP2A3 ITGA10 ITGA10 SGCA SGCA TCF7L1 TCF7L1 ITGB5 ITGB5 LEF1 LEF1 CACNG6 CACNG6 SGCD SGCD ITGA11 ITGA11 LAMA1 LAMA1 ITGAV ITGAV CACNA2D1 CACNA2D1 SLC8A3 SLC8A3 DES DES ITGB1 ITGB1 DMD DMD CACNB4 CACNB4 CTNNA2 CTNNA2 CACNA2D2 CACNA2D2 ITGA6 ITGA6 CACNB2 CACNB2 ATP2A1 ATP2A1 JUP JUP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (275 aa)
CTNNB1Beta catenin 1. (781 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
DSC2Desmocollin 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (900 aa)
ITGA9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1035 aa)
CTNNA3Catenin alpha 3. (895 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (224 aa)
RYR2Ryanodine receptor 2. (4967 aa)
DAG1Dystroglycan 1. (894 aa)
CDH2Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
ACTN2Actinin alpha 2. (894 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1033 aa)
ITGB4Integrin beta. (1805 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (663 aa)
CD63Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1224 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (484 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
DSG2Desmoglein 2. (1172 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (798 aa)
EMDEmerin. (256 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1062 aa)
CACNA2D3Calcium voltage-gated channel auxiliary subunit alpha2delta 3. (1091 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (377 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1974 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
PELOIntegrin subunit alpha 1; Belongs to the integrin alpha chain family. (1208 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2209 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (902 aa)
SGCBSarcoglycan beta. (319 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1765 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1108 aa)
SGCGSarcoglycan gamma. (291 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2184 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (808 aa)
CTNNA1Catenin alpha 1. (944 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1301 aa)
LAMA2Laminin subunit alpha 2. (3122 aa)
DSPDesmoplakin. (2874 aa)
PKP2Plakophilin 2. (836 aa)
TCF7L2Transcription factor 7 like 2. (669 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1098 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1167 aa)
SGCAIntegrin subunit alpha 3; Belongs to the integrin alpha chain family. (1075 aa)
TCF7L1Transcription factor 7 like 1. (758 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (837 aa)
LEF1Lymphoid enhancer binding factor 1. (413 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (261 aa)
SGCDSarcoglycan delta. (361 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1224 aa)
LAMA1Laminin subunit alpha 1. (3127 aa)
ITGAVFamily with sequence similarity 171 member B; Belongs to the integrin alpha chain family. (1787 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1106 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (928 aa)
DESDesmin; Belongs to the intermediate filament family. (511 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (808 aa)
DMDDystrophin. (3674 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (519 aa)
CTNNA2Catenin alpha 2. (953 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1156 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (660 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1000 aa)
JUPJunction plakoglobin. (960 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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