STRINGSTRING
tkt tkt fhcA fhcA serC serC serA_2 serA_2 gcvT_2 gcvT_2 gcvH_2 gcvH_2 gcvP gcvP fumC fumC nqo1 nqo1 ywlF ywlF acs_2 acs_2 pfkA pfkA accB accB accC accC gltA2 gltA2 pfp pfp gnl gnl cysK1_1 cysK1_1 accA accA pyk pyk fbaA fbaA cysK1_2 cysK1_2 mdh mdh tpiA tpiA sdhA sdhA MFFC18_42720 MFFC18_42720 pgi pgi gpmI gpmI metF metF accD accD eda eda pckA pckA sucC sucC sucD sucD gdhA_1 gdhA_1 fhs fhs thlA thlA lpdA lpdA talB talB pdhC_1 pdhC_1 ackA ackA acn acn MFFC18_40370 MFFC18_40370 pgk pgk kdgK_1 kdgK_1 pgl_1 pgl_1 fadB_1 fadB_1 gcvH_1 gcvH_1 pspA pspA rpe rpe pgl_2 pgl_2 MFFC18_07300 MFFC18_07300 frdA frdA frdB frdB ppdK ppdK serA_1 serA_1 fhcC fhcC acsA acsA gndA gndA zwf zwf lpd lpd sucB sucB sucA sucA ttuD ttuD paaZ paaZ mch mch gcvT_1 gcvT_1 eno eno hprA hprA fhcD fhcD glyA glyA tdcG tdcG icd icd glcK_2 glcK_2 gapA gapA pdhC_2 pdhC_2 aceE aceE prs prs MFFC18_36530 MFFC18_36530 korB korB korA korA fae_2 fae_2 ppc ppc ilvA ilvA folD folD gntK gntK glcK_1 glcK_1 fae_1 fae_1 cysE cysE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tktUnannotated protein; Belongs to the transketolase family. (676 aa)
fhcAUnannotated protein. (551 aa)
serCUnannotated protein; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (366 aa)
serA_2Unannotated protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (554 aa)
gcvT_2Unannotated protein; The glycine cleavage system catalyzes the degradation of glycine. (372 aa)
gcvH_2Unannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa)
gcvPUnannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (980 aa)
fumCUnannotated protein; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (496 aa)
nqo1Unannotated protein. (504 aa)
ywlFUnannotated protein. (149 aa)
acs_2Unannotated protein. (639 aa)
pfkAUnannotated protein. (434 aa)
accBUnannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (165 aa)
accCUnannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa)
gltA2Unannotated protein; Belongs to the citrate synthase family. (428 aa)
pfpUnannotated protein; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (366 aa)
gnlUnannotated protein. (339 aa)
cysK1_1Unannotated protein. (312 aa)
accAUnannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (324 aa)
pykUnannotated protein; Belongs to the pyruvate kinase family. (488 aa)
fbaAUnannotated protein; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (360 aa)
cysK1_2Unannotated protein. (314 aa)
mdhUnannotated protein; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (325 aa)
tpiAUnannotated protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa)
sdhAUnannotated protein. (527 aa)
MFFC18_42720Unannotated protein. (135 aa)
pgiUnannotated protein. (470 aa)
gpmIUnannotated protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (549 aa)
metFUnannotated protein; Belongs to the methylenetetrahydrofolate reductase family. (292 aa)
accDUnannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (306 aa)
edaUnannotated protein. (211 aa)
pckAUnannotated protein; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (527 aa)
sucCUnannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (394 aa)
sucDUnannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (291 aa)
gdhA_1Unannotated protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (419 aa)
fhsUnannotated protein; Belongs to the formate--tetrahydrofolate ligase family. (556 aa)
thlAUnannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa)
lpdAUnannotated protein. (475 aa)
talBUnannotated protein; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (310 aa)
pdhC_1Unannotated protein. (397 aa)
ackAUnannotated protein; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (407 aa)
acnUnannotated protein; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (900 aa)
MFFC18_40370Unannotated protein. (407 aa)
pgkUnannotated protein; Belongs to the phosphoglycerate kinase family. (394 aa)
kdgK_1Unannotated protein. (363 aa)
pgl_1Unannotated protein. (377 aa)
fadB_1Unannotated protein; Belongs to the enoyl-CoA hydratase/isomerase family. (714 aa)
gcvH_1Unannotated protein. (156 aa)
pspAUnannotated protein. (209 aa)
rpeUnannotated protein. (222 aa)
pgl_2Unannotated protein; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (241 aa)
MFFC18_07300Unannotated protein. (245 aa)
frdAUnannotated protein. (639 aa)
frdBUnannotated protein. (258 aa)
ppdKUnannotated protein; Belongs to the PEP-utilizing enzyme family. (913 aa)
serA_1Unannotated protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (326 aa)
fhcCUnannotated protein. (274 aa)
acsAUnannotated protein; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (653 aa)
gndAUnannotated protein; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (494 aa)
zwfUnannotated protein; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (510 aa)
lpdUnannotated protein. (460 aa)
sucBUnannotated protein; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (449 aa)
sucAUnannotated protein. (934 aa)
ttuDUnannotated protein. (444 aa)
paaZUnannotated protein. (179 aa)
mchUnannotated protein; Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl- H(4)MPT; Belongs to the MCH family. (323 aa)
gcvT_1Unannotated protein; Belongs to the GcvT family. (415 aa)
enoUnannotated protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (423 aa)
hprAUnannotated protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (320 aa)
fhcDUnannotated protein. (331 aa)
glyAUnannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (416 aa)
tdcGUnannotated protein; Belongs to the iron-sulfur dependent L-serine dehydratase family. (457 aa)
icdUnannotated protein; Belongs to the monomeric-type IDH family. (745 aa)
glcK_2Unannotated protein. (336 aa)
gapAUnannotated protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (337 aa)
pdhC_2Unannotated protein. (456 aa)
aceEUnannotated protein; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (905 aa)
prsUnannotated protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (320 aa)
MFFC18_36530Unannotated protein. (403 aa)
korBUnannotated protein. (336 aa)
korAUnannotated protein. (621 aa)
fae_2Unannotated protein. (182 aa)
ppcUnannotated protein; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (916 aa)
ilvAUnannotated protein. (517 aa)
folDUnannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (291 aa)
gntKUnannotated protein. (174 aa)
glcK_1Unannotated protein. (328 aa)
fae_1Unannotated protein. (165 aa)
cysEUnannotated protein. (351 aa)
Your Current Organism:
Mariniblastus fucicola
NCBI taxonomy Id: 980251
Other names: DSM 26290, LMG 29748, LMG:29748, M. fucicola, Mariniblastus fucicola Lage et al. 2017, Planctomyces sp. FC18, Planctomycetaceae bacterium FC18, strain FC18
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