(101 nodes) Serotonergic synapse network (Procavia capensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KCNJ9	Potassium inwardly rectifying channel subfamily J member 9. (315 aa)
	PLCB3	Phospholipase C beta 3. (1229 aa)
	PRKCG	Protein kinase C gamma. (697 aa)
	KCNJ3	Potassium inwardly rectifying channel subfamily J member 3. (501 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (450 aa)
	GABRB2	Gamma-aminobutyric acid type A receptor beta2 subunit. (491 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1. (393 aa)
	PLCB2	Phospholipase C beta 2. (1084 aa)
	ENSPCAP00000000456	annotation not available (501 aa)
	GNG2	G protein subunit gamma 2. (71 aa)
	GNGT2	G protein subunit gamma transducin 2. (69 aa)
	CACNA1S	Calcium voltage-gated channel subunit alpha1 S. (1872 aa)
	MAPK3	Mitogen-activated protein kinase 3. (377 aa)
	GNB2	G protein subunit beta 2. (340 aa)
	ERAS	ES cell expressed Ras. (228 aa)
	PRKCB	Protein kinase C beta. (673 aa)
	CACNA1D	Calcium voltage-gated channel subunit alpha1 D. (2146 aa)
	ENSPCAP00000005621	annotation not available (507 aa)
	GNAI2	G protein subunit alpha i2. (336 aa)
	MAOA	Monoamine oxidase A. (526 aa)
	PLA2G4F	Phospholipase A2 group IVF. (852 aa)
	HTR1B	5-hydroxytryptamine receptor 1B. (390 aa)
	PLA2G4E	Phospholipase A2 group IVE. (863 aa)
	ENSPCAP00000006740	annotation not available (459 aa)
	ENSPCAP00000006896	annotation not available (513 aa)
	GNB1	G protein subunit beta 1. (339 aa)
	HTR1A	5-hydroxytryptamine receptor 1A. (418 aa)
	HTR2A	5-hydroxytryptamine receptor 2A. (469 aa)
	HTR1F	5-hydroxytryptamine receptor 1F. (366 aa)
	PLA2G4A	Phospholipase A2 group IVA. (737 aa)
	MAOB	Monoamine oxidase B. (502 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2697 aa)
	GNB5	G protein subunit beta 5. (392 aa)
	GNAI1	G protein subunit alpha i1. (354 aa)
	HTR3A	5-hydroxytryptamine receptor 3A. (506 aa)
	GNG4	G protein subunit gamma 4. (75 aa)
	GNG3	G protein subunit gamma 3. (75 aa)
	MAPK1	Mitogen-activated protein kinase 1. (359 aa)
	ALOX12B	Arachidonate 12-lipoxygenase, 12R type. (700 aa)
	TPH1	Tryptophan hydroxylase 1. (331 aa)
	PLCB1	Phospholipase C beta 1. (1215 aa)
	KCNJ5	Potassium inwardly rectifying channel subfamily J member 5. (312 aa)
	PELP1	Proline, glutamate and leucine rich protein 1. (1269 aa)
	ENSPCAP00000010876	annotation not available (436 aa)
	PLCB4	Phospholipase C beta 4. (1044 aa)
	ENSPCAP00000010993	annotation not available (307 aa)
	ADCY5	Adenylate cyclase 5. (1257 aa)
	SLC18A2	Solute carrier family 18 member A2. (513 aa)
	TPH2	Tryptophan hydroxylase 2. (476 aa)
	HTR5A	5-hydroxytryptamine receptor 5A. (247 aa)
	PTGS1	Prostaglandin-endoperoxide synthase 1. (599 aa)
	ALOX12	Arachidonate 12-lipoxygenase, 12S type. (662 aa)
	GNG8	G protein subunit gamma 8. (70 aa)
	ENSPCAP00000012648	annotation not available (1013 aa)
	CACNA1C	Calcium voltage-gated channel subunit alpha1 C. (2205 aa)
	ENSPCAP00000012660	annotation not available (515 aa)
	GNAO1	G protein subunit alpha o1. (351 aa)
	ENSPCAP00000012853	annotation not available (244 aa)
	APP	Amyloid beta precursor protein. (761 aa)
	ARAF	A-Raf proto-oncogene, serine/threonine kinase. (604 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	CSDE1	Cold shock domain containing E1. (812 aa)
	ENSPCAP00000013647	annotation not available (441 aa)
	SLC6A4	Solute carrier family 6 member 4. (659 aa)
	GNAI3	G protein subunit alpha i3. (353 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta. (396 aa)
	GNG5	G protein subunit gamma 5. (68 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (769 aa)
	ALOX5	Arachidonate 5-lipoxygenase. (674 aa)
	ENSPCAP00000014970	annotation not available (74 aa)
	DDC	Dopa decarboxylase. (413 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (647 aa)
	CACNA1F	Calcium voltage-gated channel subunit alpha1 F. (1928 aa)
	KCNN2	Potassium calcium-activated channel subfamily N member 2. (746 aa)
	GNB3	G protein subunit beta 3. (339 aa)
	HTR2C	5-hydroxytryptamine receptor 2C. (458 aa)
	PRKCA	Protein kinase C alpha. (609 aa)
	HTR2B	5-hydroxytryptamine receptor 2B. (479 aa)
	DUSP1	Dual specificity phosphatase 1. (367 aa)
	HTR6	5-hydroxytryptamine receptor 6. (437 aa)
	ENSPCAP00000004367	annotation not available (449 aa)
	ENSPCAP00000004325	annotation not available (517 aa)
	GABRB3	Gamma-aminobutyric acid type A receptor beta3 subunit. (525 aa)
	CACNA1A	Calcium voltage-gated channel subunit alpha1 A. (2471 aa)
	ENSPCAP00000003945	annotation not available (331 aa)
	CYP2W1	Cytochrome P450 family 2 subfamily W member 1. (487 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2754 aa)
	ENSPCAP00000003493	annotation not available (312 aa)
	GNG7	G protein subunit gamma 7. (68 aa)
	GNB4	G protein subunit beta 4. (321 aa)
	ALOX15B	Arachidonate 15-lipoxygenase type B. (672 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	CASP3	Caspase 3. (277 aa)
	GNG13	G protein subunit gamma 13. (67 aa)
	TRPC1	Transient receptor potential cation channel subfamily C member 1. (794 aa)
	RAPGEF3	Rap guanine nucleotide exchange factor 3. (921 aa)
	ENSPCAP00000001960	annotation not available (525 aa)
	CACNA1B	Calcium voltage-gated channel subunit alpha1 B. (1924 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha. (350 aa)
	KCNJ6	Potassium inwardly rectifying channel subfamily J member 6. (414 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2665 aa)

Your Current Organism:

Procavia capensis

NCBI taxonomy Id: 9813
Other names: Cape hyrax, Cape rock hyrax, P. capensis, large-toothed rock hyrax, rock dassie, rock hyrax

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY5	CSDE1	ENSPCAP00000011449	ENSPCAP00000013447	Adenylate cyclase 5.	Cold shock domain containing E1.	0.491
ADCY5	ENSPCAP00000012853	ENSPCAP00000011449	ENSPCAP00000012853	Adenylate cyclase 5.	annotation not available	0.901
ADCY5	ENSPCAP00000014970	ENSPCAP00000011449	ENSPCAP00000014970	Adenylate cyclase 5.	annotation not available	0.897
ADCY5	ERAS	ENSPCAP00000011449	ENSPCAP00000006072	Adenylate cyclase 5.	ES cell expressed Ras.	0.491
ADCY5	GNAI1	ENSPCAP00000011449	ENSPCAP00000008149	Adenylate cyclase 5.	G protein subunit alpha i1.	0.926
ADCY5	GNAI2	ENSPCAP00000011449	ENSPCAP00000005569	Adenylate cyclase 5.	G protein subunit alpha i2.	0.926
ADCY5	GNAI3	ENSPCAP00000011449	ENSPCAP00000013771	Adenylate cyclase 5.	G protein subunit alpha i3.	0.926
ADCY5	GNAO1	ENSPCAP00000011449	ENSPCAP00000012714	Adenylate cyclase 5.	G protein subunit alpha o1.	0.931
ADCY5	GNB1	ENSPCAP00000011449	ENSPCAP00000007026	Adenylate cyclase 5.	G protein subunit beta 1.	0.899
ADCY5	GNB2	ENSPCAP00000011449	ENSPCAP00000006076	Adenylate cyclase 5.	G protein subunit beta 2.	0.898
ADCY5	GNB3	ENSPCAP00000011449	ENSPCAP00000015372	Adenylate cyclase 5.	G protein subunit beta 3.	0.899
ADCY5	GNB4	ENSPCAP00000011449	ENSPCAP00000003114	Adenylate cyclase 5.	G protein subunit beta 4.	0.581
ADCY5	GNB5	ENSPCAP00000011449	ENSPCAP00000008129	Adenylate cyclase 5.	G protein subunit beta 5.	0.899
ADCY5	GNG13	ENSPCAP00000011449	ENSPCAP00000002302	Adenylate cyclase 5.	G protein subunit gamma 13.	0.896
ADCY5	GNG2	ENSPCAP00000011449	ENSPCAP00000000371	Adenylate cyclase 5.	G protein subunit gamma 2.	0.902
ADCY5	GNG3	ENSPCAP00000011449	ENSPCAP00000009369	Adenylate cyclase 5.	G protein subunit gamma 3.	0.895
ADCY5	GNG4	ENSPCAP00000011449	ENSPCAP00000008440	Adenylate cyclase 5.	G protein subunit gamma 4.	0.902
ADCY5	GNG5	ENSPCAP00000011449	ENSPCAP00000014665	Adenylate cyclase 5.	G protein subunit gamma 5.	0.895
ADCY5	GNG7	ENSPCAP00000011449	ENSPCAP00000003445	Adenylate cyclase 5.	G protein subunit gamma 7.	0.895
ADCY5	GNG8	ENSPCAP00000011449	ENSPCAP00000012560	Adenylate cyclase 5.	G protein subunit gamma 8.	0.720