STRINGSTRING
SOX9 SOX9 COL10A1 COL10A1 COL27A1 COL27A1 ADAMTS4 ADAMTS4 CHI3L2 CHI3L2 MATN3 MATN3 ADAMTS5 ADAMTS5 COMP COMP TGFBI TGFBI USP35 USP35 MMP13 MMP13 USP38 USP38 SCARF1 SCARF1 TTC19 TTC19 ENG ENG LOC110258310 LOC110258310 CEP295 CEP295 COL2A1 COL2A1 C1QTNF2 C1QTNF2 ARL5B ARL5B GREM1 GREM1 ITGA10 ITGA10 CD19 CD19 CLEC3A CLEC3A COL9A3 COL9A3 LOC110258312 LOC110258312 THY1 THY1 ACAN ACAN LOC110258309 LOC110258309 CILP CILP CD79A CD79A ADAMTS3 ADAMTS3 LOC110258314 LOC110258314 C1QTNF7 C1QTNF7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
COL10A1Type X collagen. (675 aa)
COL27A1Collagen type XXVII alpha 1 chain. (1843 aa)
ADAMTS4ADAM metallopeptidase with thrombospondin type 1 motif 4. (872 aa)
CHI3L2Chitinase 3 like 2; Belongs to the glycosyl hydrolase 18 family. (430 aa)
MATN3Matrilin 3. (487 aa)
ADAMTS5ADAM metallopeptidase with thrombospondin type 1 motif 5. (929 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
TGFBITransforming growth factor-beta-induced protein ig-h3; Plays a role in cell adhesion (By similarity). May play a role in cell-collagen interactions. (709 aa)
USP35Ubiquitin specific peptidase 35; Belongs to the peptidase C19 family. (1005 aa)
MMP13Matrix metallopeptidase 13. (470 aa)
USP38Ubiquitin carboxyl-terminal hydrolase 38 isoform 1; Belongs to the peptidase C19 family. (1041 aa)
SCARF1Scavenger receptor class F member 1 isoform 1. (869 aa)
TTC19Tetratricopeptide repeat domain 19. (375 aa)
ENGEndoglin; Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells (By similarity). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a role in the binding of endothelial cells to int [...] (619 aa)
LOC110258310C1q domain-containing protein. (248 aa)
CEP295Centrosomal protein 295. (2552 aa)
COL2A1Collagen type II alpha 1 chain. (1486 aa)
C1QTNF2C1q and TNF related 2. (396 aa)
ARL5BADP-ribosylation factor-like protein 5B; Belongs to the small GTPase superfamily. Arf family. (180 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (240 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1352 aa)
CD19CD19 molecule. (645 aa)
CLEC3AC-type lectin domain family 3 member A. (196 aa)
COL9A3Collagen type IX alpha 3 chain. (684 aa)
LOC110258312Complement C1q and tumor necrosis factor-related protein 9A. (212 aa)
THY1Thy-1 cell surface antigen. (165 aa)
ACANAggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2434 aa)
LOC110258309C1q domain-containing protein. (189 aa)
CILPCartilage intermediate layer protein 1 C2; Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage (By similarity). (1193 aa)
CD79AIg-like domain-containing protein. (234 aa)
ADAMTS3ADAM metallopeptidase with thrombospondin type 1 motif 3. (1220 aa)
LOC110258314C1q domain-containing protein. (174 aa)
C1QTNF7C1q and TNF related 7. (311 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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