34 items (Sus scrofa) - STRING interaction network

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Your Input:
	SOX9	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
	COL10A1	Type X collagen. (675 aa)
	COL27A1	Collagen type XXVII alpha 1 chain. (1843 aa)
	ADAMTS4	ADAM metallopeptidase with thrombospondin type 1 motif 4. (872 aa)
	CHI3L2	Chitinase 3 like 2; Belongs to the glycosyl hydrolase 18 family. (430 aa)
	MATN3	Matrilin 3. (487 aa)
	ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif 5. (929 aa)
	COMP	Cartilage oligomeric matrix protein. (756 aa)
	TGFBI	Transforming growth factor-beta-induced protein ig-h3; Plays a role in cell adhesion (By similarity). May play a role in cell-collagen interactions. (709 aa)
	USP35	Ubiquitin specific peptidase 35; Belongs to the peptidase C19 family. (1005 aa)
	MMP13	Matrix metallopeptidase 13. (470 aa)
	USP38	Ubiquitin carboxyl-terminal hydrolase 38 isoform 1; Belongs to the peptidase C19 family. (1041 aa)
	SCARF1	Scavenger receptor class F member 1 isoform 1. (869 aa)
	TTC19	Tetratricopeptide repeat domain 19. (375 aa)
	ENG	Endoglin; Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells (By similarity). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a role in the binding of endothelial cells to int [...] (619 aa)
	LOC110258310	C1q domain-containing protein. (248 aa)
	CEP295	Centrosomal protein 295. (2552 aa)
	COL2A1	Collagen type II alpha 1 chain. (1486 aa)
	C1QTNF2	C1q and TNF related 2. (396 aa)
	ARL5B	ADP-ribosylation factor-like protein 5B; Belongs to the small GTPase superfamily. Arf family. (180 aa)
	GREM1	Gremlin 1, DAN family BMP antagonist. (240 aa)
	ITGA10	Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1352 aa)
	CD19	CD19 molecule. (645 aa)
	CLEC3A	C-type lectin domain family 3 member A. (196 aa)
	COL9A3	Collagen type IX alpha 3 chain. (684 aa)
	LOC110258312	Complement C1q and tumor necrosis factor-related protein 9A. (212 aa)
	THY1	Thy-1 cell surface antigen. (165 aa)
	ACAN	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2434 aa)
	LOC110258309	C1q domain-containing protein. (189 aa)
	CILP	Cartilage intermediate layer protein 1 C2; Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage (By similarity). (1193 aa)
	CD79A	Ig-like domain-containing protein. (234 aa)
	ADAMTS3	ADAM metallopeptidase with thrombospondin type 1 motif 3. (1220 aa)
	LOC110258314	C1q domain-containing protein. (174 aa)
	C1QTNF7	C1q and TNF related 7. (311 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAN	ADAMTS3	ENSSSCP00000052661	ENSSSCP00000065940	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	ADAM metallopeptidase with thrombospondin type 1 motif 3.	0.506
ACAN	ADAMTS4	ENSSSCP00000052661	ENSSSCP00000006778	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	ADAM metallopeptidase with thrombospondin type 1 motif 4.	0.915
ACAN	ADAMTS5	ENSSSCP00000052661	ENSSSCP00000012809	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	ADAM metallopeptidase with thrombospondin type 1 motif 5.	0.890
ACAN	CILP	ENSSSCP00000052661	ENSSSCP00000059189	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Cartilage intermediate layer protein 1 C2; Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage (By similarity).	0.486
ACAN	COL10A1	ENSSSCP00000052661	ENSSSCP00000004785	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Type X collagen.	0.891
ACAN	COL2A1	ENSSSCP00000052661	ENSSSCP00000036099	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Collagen type II alpha 1 chain.	0.950
ACAN	COMP	ENSSSCP00000052661	ENSSSCP00000014796	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Cartilage oligomeric matrix protein.	0.945
ACAN	ENG	ENSSSCP00000052661	ENSSSCP00000030121	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Endoglin; Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells (By similarity). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a role in the binding of endothelial cells to int [...]	0.477
ACAN	MATN3	ENSSSCP00000052661	ENSSSCP00000009174	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Matrilin 3.	0.733
ACAN	MMP13	ENSSSCP00000052661	ENSSSCP00000015912	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Matrix metallopeptidase 13.	0.923
ACAN	SOX9	ENSSSCP00000052661	ENSSSCP00000018278	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.945
ACAN	THY1	ENSSSCP00000052661	ENSSSCP00000050686	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Thy-1 cell surface antigen.	0.498
ADAMTS3	ACAN	ENSSSCP00000065940	ENSSSCP00000052661	ADAM metallopeptidase with thrombospondin type 1 motif 3.	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	0.506
ADAMTS3	COL27A1	ENSSSCP00000065940	ENSSSCP00000005883	ADAM metallopeptidase with thrombospondin type 1 motif 3.	Collagen type XXVII alpha 1 chain.	0.453
ADAMTS3	COL2A1	ENSSSCP00000065940	ENSSSCP00000036099	ADAM metallopeptidase with thrombospondin type 1 motif 3.	Collagen type II alpha 1 chain.	0.554
ADAMTS3	MMP13	ENSSSCP00000065940	ENSSSCP00000015912	ADAM metallopeptidase with thrombospondin type 1 motif 3.	Matrix metallopeptidase 13.	0.431
ADAMTS4	ACAN	ENSSSCP00000006778	ENSSSCP00000052661	ADAM metallopeptidase with thrombospondin type 1 motif 4.	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	0.915
ADAMTS4	COL10A1	ENSSSCP00000006778	ENSSSCP00000004785	ADAM metallopeptidase with thrombospondin type 1 motif 4.	Type X collagen.	0.574
ADAMTS4	COL2A1	ENSSSCP00000006778	ENSSSCP00000036099	ADAM metallopeptidase with thrombospondin type 1 motif 4.	Collagen type II alpha 1 chain.	0.751
ADAMTS4	COMP	ENSSSCP00000006778	ENSSSCP00000014796	ADAM metallopeptidase with thrombospondin type 1 motif 4.	Cartilage oligomeric matrix protein.	0.547