node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAN | ADAMTS3 | ENSSSCP00000052661 | ENSSSCP00000065940 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | ADAM metallopeptidase with thrombospondin type 1 motif 3. | 0.506 |
ACAN | ADAMTS4 | ENSSSCP00000052661 | ENSSSCP00000006778 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | ADAM metallopeptidase with thrombospondin type 1 motif 4. | 0.915 |
ACAN | ADAMTS5 | ENSSSCP00000052661 | ENSSSCP00000012809 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | ADAM metallopeptidase with thrombospondin type 1 motif 5. | 0.890 |
ACAN | CILP | ENSSSCP00000052661 | ENSSSCP00000059189 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Cartilage intermediate layer protein 1 C2; Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage (By similarity). | 0.486 |
ACAN | COL10A1 | ENSSSCP00000052661 | ENSSSCP00000004785 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Type X collagen. | 0.891 |
ACAN | COL2A1 | ENSSSCP00000052661 | ENSSSCP00000036099 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Collagen type II alpha 1 chain. | 0.950 |
ACAN | COMP | ENSSSCP00000052661 | ENSSSCP00000014796 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Cartilage oligomeric matrix protein. | 0.945 |
ACAN | ENG | ENSSSCP00000052661 | ENSSSCP00000030121 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Endoglin; Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells (By similarity). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a role in the binding of endothelial cells to int [...] | 0.477 |
ACAN | MATN3 | ENSSSCP00000052661 | ENSSSCP00000009174 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Matrilin 3. | 0.733 |
ACAN | MMP13 | ENSSSCP00000052661 | ENSSSCP00000015912 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Matrix metallopeptidase 13. | 0.923 |
ACAN | SOX9 | ENSSSCP00000052661 | ENSSSCP00000018278 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. | 0.945 |
ACAN | THY1 | ENSSSCP00000052661 | ENSSSCP00000050686 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Thy-1 cell surface antigen. | 0.498 |
ADAMTS3 | ACAN | ENSSSCP00000065940 | ENSSSCP00000052661 | ADAM metallopeptidase with thrombospondin type 1 motif 3. | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | 0.506 |
ADAMTS3 | COL27A1 | ENSSSCP00000065940 | ENSSSCP00000005883 | ADAM metallopeptidase with thrombospondin type 1 motif 3. | Collagen type XXVII alpha 1 chain. | 0.453 |
ADAMTS3 | COL2A1 | ENSSSCP00000065940 | ENSSSCP00000036099 | ADAM metallopeptidase with thrombospondin type 1 motif 3. | Collagen type II alpha 1 chain. | 0.554 |
ADAMTS3 | MMP13 | ENSSSCP00000065940 | ENSSSCP00000015912 | ADAM metallopeptidase with thrombospondin type 1 motif 3. | Matrix metallopeptidase 13. | 0.431 |
ADAMTS4 | ACAN | ENSSSCP00000006778 | ENSSSCP00000052661 | ADAM metallopeptidase with thrombospondin type 1 motif 4. | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | 0.915 |
ADAMTS4 | COL10A1 | ENSSSCP00000006778 | ENSSSCP00000004785 | ADAM metallopeptidase with thrombospondin type 1 motif 4. | Type X collagen. | 0.574 |
ADAMTS4 | COL2A1 | ENSSSCP00000006778 | ENSSSCP00000036099 | ADAM metallopeptidase with thrombospondin type 1 motif 4. | Collagen type II alpha 1 chain. | 0.751 |
ADAMTS4 | COMP | ENSSSCP00000006778 | ENSSSCP00000014796 | ADAM metallopeptidase with thrombospondin type 1 motif 4. | Cartilage oligomeric matrix protein. | 0.547 |