STRINGSTRING
AGXT2 AGXT2 CDK2 CDK2 MLC1 MLC1 CDKN1A CDKN1A ACSBG1 ACSBG1 PRIMA1 PRIMA1 TDRD9 TDRD9 PIGV PIGV NOL4 NOL4 CCDC198 CCDC198 AEN AEN IFNB1 IFNB1 VCPIP1 VCPIP1 F5 F5 PCSK2 PCSK2 ANKS4B ANKS4B ANXA5 ANXA5 ADAMTSL5 ADAMTSL5 ALG9 ALG9 CLDN4 CLDN4 CFAP47 CFAP47 A0A5G2RB98_PIG A0A5G2RB98_PIG SPATS2 SPATS2 FBXO28 FBXO28 DNAJB8 DNAJB8 SCN5A SCN5A POLE4 POLE4 EGFR EGFR MUC2 MUC2 TEX48 TEX48 A0A5G2R326_PIG A0A5G2R326_PIG DNAJB6 DNAJB6 A0A5G2QI01_PIG A0A5G2QI01_PIG XPO4 XPO4 EXOC5 EXOC5 PPP1R14D PPP1R14D TM9SF2 TM9SF2 KPNA6 KPNA6 CCND1 CCND1 TMEM98 TMEM98 TRIB3 TRIB3 CCDC122 CCDC122 CCDC171 CCDC171 PPFIBP2 PPFIBP2 TJP1 TJP1 SSC5D SSC5D ALB ALB DIP2A DIP2A WDR89 WDR89 DNM2 DNM2 A0A287B8J8_PIG A0A287B8J8_PIG FAM151A FAM151A SDHAF2 SDHAF2 HRAS HRAS TP53 TP53 KRCC1 KRCC1 MOB1A MOB1A MAK16 MAK16 ESS2 ESS2 TFF1 TFF1 ASPH ASPH NRAS NRAS MUC5AC MUC5AC ST3GAL3 ST3GAL3 MISP MISP IL1B IL1B OCLN OCLN BOK BOK BARX2 BARX2 TRRAP TRRAP CLVS1 CLVS1 FGFR3 FGFR3 LIMA1 LIMA1 UPK3A UPK3A TMPRSS2 TMPRSS2 ACTG1 ACTG1 NOVA1 NOVA1 CBLC CBLC NSUN7 NSUN7 KAZALD1 KAZALD1 ACTBL2 ACTBL2 ABI2 ABI2 PSMB8 PSMB8 CLDN1 CLDN1 ARPC2 ARPC2 SCNN1A SCNN1A MIER1 MIER1 TNKS TNKS SALL2 SALL2 ACTB ACTB C1GALT1C1 C1GALT1C1 RB1 RB1 PCDH17 PCDH17 LOXL4 LOXL4 ELF3 ELF3 ATR ATR TM4SF18 TM4SF18 NR1I2 NR1I2 GRPR GRPR STK11 STK11 ELAVL3 ELAVL3 MYO7A MYO7A UPK2 UPK2 CCNT2 CCNT2 ZDBF2 ZDBF2 TMEM229A TMEM229A DTX2 DTX2 ACTL8 ACTL8 DNAJB3 DNAJB3 SLC46A1 SLC46A1 NT5C3A NT5C3A APEH APEH PCSK9 PCSK9 ATOH7 ATOH7 HECTD2 HECTD2 HEMK1 HEMK1 TWNK TWNK CD59 CD59 NYAP1 NYAP1 RPS6KA5 RPS6KA5 FMNL3 FMNL3 LOC100622121 LOC100622121 TMEM158 TMEM158 LYVE1 LYVE1 BRCA2 BRCA2 RIPK2 RIPK2 ACE2 ACE2 MTMR1 MTMR1 MX1 MX1 S100A2 S100A2 MALT1 MALT1 JAK3 JAK3 ESR1 ESR1 CLTRN CLTRN SNAI3 SNAI3 KCNH7 KCNH7 PHTF2 PHTF2 LIPI LIPI SPAG9 SPAG9 CTNNB1 CTNNB1 TMEM156 TMEM156 DNAJB7 DNAJB7 KLK8 KLK8 ENDOU ENDOU NUP88 NUP88 NOVA2 NOVA2 PROCA1 PROCA1 CDC14B CDC14B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGXT2Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (497 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (381 aa)
MLC1Modulator of VRAC current 1. (373 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (163 aa)
ACSBG1Acyl-CoA synthetase bubblegum family member 1. (709 aa)
PRIMA1Uncharacterized protein. (313 aa)
TDRD9Tudor domain containing 9. (1389 aa)
PIGVGPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. (493 aa)
NOL4Nucleolar protein 4. (592 aa)
CCDC198Coiled-coil domain containing 198. (299 aa)
AENApoptosis enhancing nuclease. (325 aa)
IFNB1Interferon-beta-1. (186 aa)
VCPIP1Valosin containing protein interacting protein 1. (1223 aa)
F5Coagulation factor V heavy chain; Coagulation factor V is a cofactor that participates with factor Xa to activate prothrombin to thrombin; Belongs to the multicopper oxidase family. (2258 aa)
PCSK2Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity). (638 aa)
ANKS4BAnkyrin repeat and sterile alpha motif domain containing 4B. (417 aa)
ANXA5Annexin. (321 aa)
ADAMTSL5ADAMTS-like protein 5 isoform X2. (484 aa)
ALG9Mannosyltransferase. (641 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
CFAP47Uncharacterized protein. (952 aa)
A0A5G2RB98_PIGUncharacterized protein. (248 aa)
SPATS2Spermatogenesis associated serine rich 2. (546 aa)
FBXO28F-box protein 28. (367 aa)
DNAJB8DnaJ heat shock protein family (Hsp40) member B8. (287 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1887 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (138 aa)
EGFRReceptor protein-tyrosine kinase. (1205 aa)
MUC2Uncharacterized protein. (3289 aa)
TEX48Testis expressed 48. (119 aa)
A0A5G2R326_PIGCLLAC domain-containing protein. (492 aa)
DNAJB6DnaJ heat shock protein family (Hsp40) member B6. (330 aa)
A0A5G2QI01_PIGUncharacterized protein. (109 aa)
XPO4Exportin 4. (1171 aa)
EXOC5Exocyst complex component 5. (767 aa)
PPP1R14DProtein phosphatase 1 regulatory inhibitor subunit 14D. (183 aa)
TM9SF2Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (663 aa)
KPNA6Importin subunit alpha; Functions in nuclear protein import. (578 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
TMEM98Transmembrane protein 98. (226 aa)
TRIB3Tribbles pseudokinase 3. (373 aa)
CCDC122Coiled-coil domain containing 122. (430 aa)
CCDC171Coiled-coil domain-containing protein 171. (1333 aa)
PPFIBP2PPFIA binding protein 2. (979 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1862 aa)
SSC5DScavenger receptor cysteine rich family member with 5 domains. (1634 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (659 aa)
DIP2ADisco interacting protein 2 homolog A. (1514 aa)
WDR89WD repeat domain 89. (430 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (877 aa)
A0A287B8J8_PIGUncharacterized protein. (617 aa)
FAM151AFamily with sequence similarity 151 member A. (585 aa)
SDHAF2Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (172 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa)
KRCC1Lysine rich coiled-coil 1. (266 aa)
MOB1AMOB kinase activator 1A. (214 aa)
MAK16Protein MAK16 homolog; Belongs to the MAK16 family. (297 aa)
ESS2Ess-2 splicing factor homolog. (521 aa)
TFF1P-type domain-containing protein. (86 aa)
ASPHAspartate beta-hydroxylase. (788 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
MUC5ACUncharacterized protein. (3330 aa)
ST3GAL3CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X1; Belongs to the glycosyltransferase 29 family. (374 aa)
MISPMitotic interactor and substrate of PLK1 isoform X1. (650 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (267 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (533 aa)
BOKBCL2 family apoptosis regulator BOK. (288 aa)
BARX2BARX homeobox 2. (278 aa)
TRRAPTransformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. (3858 aa)
CLVS1Clavesin 1. (356 aa)
FGFR3Fibroblast growth factor receptor. (855 aa)
LIMA1LIM domain and actin-binding protein 1; Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (By similarity). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholest [...] (766 aa)
UPK3AUroplakin 3A. (285 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (526 aa)
ACTG1Actin gamma 1. (381 aa)
NOVA1NOVA alternative splicing regulator 1. (487 aa)
CBLCCbl proto-oncogene C. (561 aa)
NSUN7NOP2/Sun RNA methyltransferase family member 7; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (724 aa)
KAZALD1Kazal-type serine protease inhibitor domain-containing protein 1 isoform X1. (315 aa)
ACTBL2Actin beta like 2. (385 aa)
ABI2Abl interactor 2. (542 aa)
PSMB8Proteasome subunit beta type-8; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. May participate in the generation of spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein (By similarity). Required for adip [...] (295 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (273 aa)
SCNN1AAmiloride-sensitive sodium channel subunit alpha isoform 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (650 aa)
MIER1MIER1 transcriptional regulator. (633 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
SALL2Spalt like transcription factor 2. (1032 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
C1GALT1C1Uncharacterized protein. (318 aa)
RB1RB transcriptional corepressor 1. (938 aa)
PCDH17Protocadherin 17. (1189 aa)
LOXL4Lysyl oxidase like 4. (757 aa)
ELF3E74 like ETS transcription factor 3. (456 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2643 aa)
TM4SF18Transmembrane 4 L six family member 18. (201 aa)
NR1I2Nuclear receptor subfamily 1 group I member 2. (437 aa)
GRPRGastrin releasing peptide receptor; Belongs to the G-protein coupled receptor 1 family. (395 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
ELAVL3ELAV-like protein; Belongs to the RRM elav family. (367 aa)
MYO7AUnconventional myosin-VIIa; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differenti [...] (2213 aa)
UPK2Uroplakin-2; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM (By similarity); Belongs to the uroplakin-2 family. (185 aa)
CCNT2Cyclin T2; Belongs to the cyclin family. (618 aa)
ZDBF2Zinc finger DBF-type containing 2. (2524 aa)
TMEM229ATransmembrane protein 229A. (370 aa)
DTX2Deltex E3 ubiquitin ligase 2. (729 aa)
ACTL8Actin like 8; Belongs to the actin family. (365 aa)
DNAJB3J domain-containing protein. (254 aa)
SLC46A1Uncharacterized protein. (458 aa)
NT5C3A5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (313 aa)
APEHAcylamino-acid-releasing enzyme; This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser; Belongs to the peptidase S9C family. (757 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9. (678 aa)
ATOH7Atonal bHLH transcription factor 7. (155 aa)
HECTD2HECT domain E3 ubiquitin protein ligase 2. (776 aa)
HEMK1HemK methyltransferase family member 1. (339 aa)
TWNKTwinkle protein, mitochondrial isoform A. (684 aa)
CD59CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. (123 aa)
NYAP1Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 isoform X1. (840 aa)
RPS6KA5Non-specific serine/threonine protein kinase. (957 aa)
FMNL3Formin-like protein 3 isoform X4. (1027 aa)
LOC100622121Uncharacterized protein. (318 aa)
TMEM158Transmembrane protein 158 (gene/pseudogene). (295 aa)
LYVE1Lymphatic vessel endothelial hyaluronic acid receptor 1 isoform X2. (326 aa)
BRCA2Tower domain-containing protein. (1163 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (533 aa)
ACE2Angiotensin-converting enzyme. (805 aa)
MTMR1Myotubularin related protein 1. (671 aa)
MX1Interferon-induced GTP-binding protein Mx1; Interferon-induced dynamin-like GTPase with antiviral activity against influenza A virus, (IAV). Inhibits IAV replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. (650 aa)
S100A2S100 calcium binding protein A2. (170 aa)
MALT1Mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1. (850 aa)
JAK3Tyrosine-protein kinase. (1103 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa)
CLTRNCollectrin. (247 aa)
SNAI3Snail family transcriptional repressor 3. (283 aa)
KCNH7Potassium voltage-gated channel subfamily H member 7. (1198 aa)
PHTF2Putative homeodomain transcription factor 2 isoform X1. (751 aa)
LIPILipase I. (480 aa)
SPAG9Sperm associated antigen 9. (1338 aa)
CTNNB1Catenin beta 1. (808 aa)
TMEM156Transmembrane protein 156 isoform 1. (313 aa)
DNAJB7Uncharacterized protein. (114 aa)
KLK8Kallikrein related peptidase 8; Belongs to the peptidase S1 family. (259 aa)
ENDOUEndonuclease, poly(U) specific. (410 aa)
NUP88Nucleoporin 88. (739 aa)
NOVA2NOVA alternative splicing regulator 2. (492 aa)
PROCA1Protein interacting with cyclin A1. (392 aa)
CDC14BUncharacterized protein. (542 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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