STRINGSTRING
ZNF507 ZNF507 FAM172A FAM172A ACTL8 ACTL8 ENDOV ENDOV TLR3 TLR3 SORBS2 SORBS2 S100G S100G MUC13 MUC13 PIGO PIGO BRAT1 BRAT1 WDFY3 WDFY3 FAM3C FAM3C SPAI-2 SPAI-2 HOOK3 HOOK3 NRF1 NRF1 PPP1R37 PPP1R37 ZNF248 ZNF248 HAUS6 HAUS6 ADAT2 ADAT2 MFSD1 MFSD1 ABCE1 ABCE1 DHX37 DHX37 TMPRSS15 TMPRSS15 RNF121 RNF121 ANPEP ANPEP RPL4 RPL4 ERLIN2 ERLIN2 SLC38A6 SLC38A6 UVSSA UVSSA ZNF644 ZNF644 NSUN4 NSUN4 SST SST PDSS1 PDSS1 PNLIPRP2 PNLIPRP2 ANKRD9 ANKRD9 ACTG1 ACTG1 NUFIP1 NUFIP1 ACTBL2 ACTBL2 KLHL15 KLHL15 ACTB ACTB GAPDH GAPDH CCK CCK MAMDC2 MAMDC2 FBXL19 FBXL19 MFSD14A MFSD14A VIP VIP TFF2 TFF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZNF507Zinc finger protein 507. (1002 aa)
FAM172AFamily with sequence similarity 172 member A. (416 aa)
ACTL8Actin like 8; Belongs to the actin family. (365 aa)
ENDOVEndonuclease V. (250 aa)
TLR3TIR domain-containing protein; Belongs to the Toll-like receptor family. (903 aa)
SORBS2Sorbin and SH3 domain-containing protein 2; Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1 (By similarity). May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12. Increases water and sodium absorption in the intestine [...] (1432 aa)
S100GProtein S100-G, minor isoform; Belongs to the S-100 family. (108 aa)
MUC13Uncharacterized protein. (537 aa)
PIGOPhosphatidylinositol glycan anchor biosynthesis class O. (1131 aa)
BRAT1BRCA1-associated ATM activator 1 isoform 2. (822 aa)
WDFY3WD repeat and FYVE domain containing 3. (3526 aa)
FAM3CFamily with sequence similarity 3 member C. (227 aa)
SPAI-2Sodium/potassium ATPase inhibitor SPAI-2; Inhibits Na(+),K(+) ATPase by the competitive mode against Na(+). (187 aa)
HOOK3Hook microtubule tethering protein 3. (786 aa)
NRF1Nuclear respiratory factor 1 isoform 1. (503 aa)
PPP1R37Protein phosphatase 1 regulatory subunit 37. (695 aa)
ZNF248Zinc finger protein 248 isoform 1. (580 aa)
HAUS6HAUS augmin like complex subunit 6. (965 aa)
ADAT2Adenosine deaminase tRNA specific 2. (230 aa)
MFSD1Major facilitator superfamily domain-containing protein 1. (468 aa)
ABCE1ATP binding cassette subfamily E member 1. (589 aa)
DHX37DEAH-box helicase 37. (1186 aa)
TMPRSS15Enteropeptidase non-catalytic heavy chain; Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases. (1049 aa)
RNF121Ring finger protein 121. (328 aa)
ANPEPAminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization (By similarity). It is able to degrade Leu-enkephalin and Met [...] (1017 aa)
RPL460S ribosomal protein L4; Belongs to the universal ribosomal protein uL4 family. (449 aa)
ERLIN2ER lipid raft associated 2. (384 aa)
SLC38A6Solute carrier family 38 member 6. (463 aa)
UVSSAUV stimulated scaffold protein A. (821 aa)
ZNF644Zinc finger protein 644. (1368 aa)
NSUN4NOP2/Sun RNA methyltransferase 4; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (382 aa)
SSTSomatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin. (116 aa)
PDSS1Decaprenyl diphosphate synthase subunit 1; Belongs to the FPP/GGPP synthase family. (409 aa)
PNLIPRP2Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (574 aa)
ANKRD9Uncharacterized protein. (360 aa)
ACTG1Actin gamma 1. (381 aa)
NUFIP1Nuclear fragile X mental retardation-interacting protein 1. (494 aa)
ACTBL2Actin beta like 2. (385 aa)
KLHL15Kelch like family member 15. (614 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (398 aa)
CCKCholecystokinin-58 desnonopeptide; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. (154 aa)
MAMDC2MAM domain containing 2. (685 aa)
FBXL19F-box and leucine rich repeat protein 19. (694 aa)
MFSD14AMFS domain-containing protein. (453 aa)
VIPVasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder; Belongs to the glucagon family. (167 aa)
TFF2Trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. (165 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (30%) [HD]