Your Input: | |
| | IL1B2 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa) |
| | KRT5 | Keratin 5; Belongs to the intermediate filament family. (602 aa) |
| | ORMDL2 | ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa) |
| | VWF | Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). (2940 aa) |
| | ABCD2 | ATP-binding cassette sub-family D member 2 isoform X1. (741 aa) |
| | STAB2 | Uncharacterized protein. (2550 aa) |
| | IGF1 | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (230 aa) |
| | DSP | Desmoplakin. (2883 aa) |
| | PSMB11 | Proteasome subunit beta. (291 aa) |
| | VSX2 | Visual system homeobox 2. (361 aa) |
| | MARVELD3 | MARVEL domain-containing protein. (390 aa) |
| | KCNN4 | Intermediate conductance calcium-activated potassium channel protein 4. (426 aa) |
| | TAS1R3 | G_PROTEIN_RECEP_F3_4 domain-containing protein. (855 aa) |
| | PDPN | Uncharacterized protein. (159 aa) |
| | AUNIP | Aurora kinase A and ninein interacting protein. (385 aa) |
| | RPE65 | Retinoid isomerohydrolase RPE65. (533 aa) |
| | TIE1 | Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa) |
| | GJA1 | Gap junction alpha-1 protein; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli a [...] (382 aa) |
| | FAM189A1 | Family with sequence similarity 189 member A1. (538 aa) |
| | SERPINB10 | SERPIN domain-containing protein; Belongs to the serpin family. (397 aa) |
| | NOX5 | NADPH oxidase 5. (799 aa) |
| | PRKCH | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (522 aa) |
| | CD274 | CD274 molecule. (311 aa) |
| | EPB41L4B | Erythrocyte membrane protein band 4.1 like 4B. (895 aa) |
| | SELE | E-selectin; Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis (By similarity). Belongs to the selectin/LECAM family. (484 aa) |
| | OR10K2 | Olfactory receptor family 10 subfamily K member 2. (313 aa) |
| | PAQR6 | Uncharacterized protein. (375 aa) |
| | S100A5 | Protein S100; Belongs to the S-100 family. (93 aa) |
| | VTCN1 | V-set domain containing T cell activation inhibitor 1. (282 aa) |
| | VCAM1 | Uncharacterized protein. (537 aa) |
| | PFDN4 | Prefoldin subunit 4; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit beta family. (134 aa) |
| | GCNT7 | Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7; Glycosyltransferase. (429 aa) |
| | EPHB4 | EPH receptor B4. (935 aa) |
| | PRSS36 | Polyserase-2; Serine protease. Has a preference for substrates with an Arg instead of a Lys residue in position P1. Belongs to the peptidase S1 family. (855 aa) |
| | GP2 | Pancreatic secretory granule membrane major glycoprotein GP2 isoform 1. (532 aa) |
| | RHBDL1 | Rhomboid-related protein 1; May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 family. (373 aa) |
| | LOC100524016 | Uncharacterized protein. (593 aa) |
| | LOC110258578 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa) |
| | ATOH8 | Atonal bHLH transcription factor 8. (315 aa) |
| | ANXA4 | Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis; Belongs to the annexin family. (337 aa) |
| | EPCAM | Epithelial cell adhesion molecule; May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E (By similarity). Belongs to the EPCAM family. (340 aa) |
| | PREB | Prolactin regulatory element binding. (418 aa) |
| | AMTN | Amelotin. (209 aa) |
| | AMBN | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family. (421 aa) |
| | ANXA5 | Annexin. (321 aa) |
| | MMRN1 | Multimerin 1. (1220 aa) |
| | SCD5 | Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (332 aa) |
| | CSN2 | Beta-casein; Important role in determination of the surface properties of the casein micelles. (231 aa) |
| | ALG5 | Glyco_trans_2-like domain-containing protein. (323 aa) |
| | GOLGA3 | Golgin A3. (1471 aa) |
| | SLC5A1 | Sodium/glucose cotransporter 1; Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. (690 aa) |
| | CSGALNACT2 | Hexosyltransferase. (542 aa) |
| | ENTPD1 | Ectonucleoside triphosphate diphosphohydrolase 1 27 kDa subunit; In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. (510 aa) |
| | ZRANB1 | Zinc finger RANBP2-type containing 1. (734 aa) |
| | NISCH | Nischarin. (1520 aa) |
| | RHO | Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity). (348 aa) |
| | CLDN18 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa) |
| | SKIL | Ski-like protein isoform X1. (661 aa) |
| | SLC51A | Solute carrier family 51 alpha subunit. (340 aa) |
| | MUC13 | Uncharacterized protein. (537 aa) |
| | GOLGB1 | Golgin B1. (3270 aa) |
| | CLDND1 | Claudin domain containing 1. (336 aa) |
| | OBP | Odorant-binding protein; This protein is found in nasal epithelium and it binds a wide variety of chemical odorants. (173 aa) |
| | VEGFD | Vascular endothelial growth factor D preproprotein; Belongs to the PDGF/VEGF growth factor family. (354 aa) |
| | AR | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (896 aa) |
| | CNGA2 | Cyclic nucleotide gated channel subunit alpha 2. (663 aa) |
| | ABCD1 | ATP binding cassette subfamily D member 1. (732 aa) |
| | B4GAT1 | Beta-1,4-glucuronyltransferase 1. (415 aa) |
| | FLT4 | Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1362 aa) |
| | SLCO4C1 | Solute carrier organic anion transporter family member. (718 aa) |
| | TSLP | Uncharacterized protein. (58 aa) |
| | NEUROG1 | Neurogenin 1. (246 aa) |
| | POU4F3 | POU domain protein. (338 aa) |
| | LOC100522088 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (312 aa) |
| | CNGA4 | Cyclic nucleotide gated channel subunit alpha 4. (591 aa) |
| | PGR | Progesterone receptor isoform B. (934 aa) |
| | MMP20 | Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation (By similarity). (483 aa) |
| | UPK2 | Uroplakin-2; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM (By similarity); Belongs to the uroplakin-2 family. (185 aa) |
| | CHEK1 | Serine/threonine-protein kinase Chk1 isoform X2; Belongs to the protein kinase superfamily. (476 aa) |
| | GNAT3 | G protein subunit alpha transducin 3. (354 aa) |
| | CHIT1 | Chitinase 1; Belongs to the glycosyl hydrolase 18 family. (466 aa) |
| | NPHS2 | NPHS2 stomatin family member, podocin. (378 aa) |
| | PTPN14 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1186 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (219 aa) |
| | EPC2 | Enhancer of polycomb homolog. (807 aa) |
| | VEGFC | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa) |
| | TRAPPC11 | Trafficking protein particle complex 11. (1134 aa) |
| | TLR3 | TIR domain-containing protein; Belongs to the Toll-like receptor family. (903 aa) |
| | PODXL | Podocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family. (516 aa) |
| | NPC1L1 | NPC1-like intracellular cholesterol transporter 1 isoform 2. (1332 aa) |
| | FOXJ1 | Forkhead box J1. (421 aa) |
| | ERN1 | Uncharacterized protein. (1029 aa) |
| | GFAP | Glial fibrillary acidic protein; Belongs to the intermediate filament family. (468 aa) |
| | STAT3 | Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] (772 aa) |
| | JUP | Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...] (744 aa) |
| | CCR7 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (477 aa) |
| | TNS4 | Tensin-4. (716 aa) |
| | ERBB2 | Receptor protein-tyrosine kinase. (1255 aa) |
| | DGKE | Diacylglycerol kinase. (566 aa) |
| | FOXN1 | Forkhead box N1. (671 aa) |
| | CD4 | CD4 molecule. (494 aa) |
| | POU4F2 | POU domain protein. (408 aa) |
| | WT1 | Wilms tumor protein homolog; Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isofor [...] (523 aa) |
| | KLK4 | Enamel matrix serine proteinase 1; Belongs to the peptidase S1 family. (254 aa) |
| | MMP17 | Matrix metalloproteinase-17 preproprotein. (595 aa) |
| | ACTL8 | Actin like 8; Belongs to the actin family. (365 aa) |
| | OR10J1 | Olfactory receptor family 10 subfamily J member 1. (320 aa) |
| | DSG1 | Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (By similarity). (1045 aa) |
| | GKN1 | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium. (198 aa) |
| | SLC39A2 | Solute carrier family 39 member 2. (309 aa) |
| | CDH3 | Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. (826 aa) |
| | ARHGEF38 | Rho guanine nucleotide exchange factor 38. (778 aa) |
| | FBN3 | Fibrillin 3. (2858 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa) |
| | LALBA | Alpha-lactalbumin; Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N- acetylglucosamine of the oligosaccharide chains in glycoproteins. (141 aa) |
| | CCNO | Cyclin-O; Belongs to the cyclin family. (351 aa) |
| | TFF3 | Trefoil factor 3; Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen) (By similarity). (109 aa) |
| | CHIA | Chitin-binding type-2 domain-containing protein; Belongs to the glycosyl hydrolase 18 family. (478 aa) |
| | P4HA3 | Prolyl 4-hydroxylase subunit alpha-3 isoform 1. (544 aa) |
| | MSLNL | Mesothelin like. (716 aa) |
| | KIF22 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (753 aa) |
| | CNKSR1 | Connector enhancer of kinase suppressor of Ras 1. (648 aa) |
| | NES | Nestin; Belongs to the intermediate filament family. (1699 aa) |
| | CD59 | CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. (123 aa) |
| | AIRE | Autoimmune regulator. (559 aa) |
| | HIGD2A | HIG1 domain-containing protein. (106 aa) |
| | LYVE1 | Lymphatic vessel endothelial hyaluronic acid receptor 1 isoform X2. (326 aa) |
| | LIPG | Lipase G, endothelial type. (501 aa) |
| | KCNS1 | Potassium voltage-gated channel modifier subfamily S member 1; Belongs to the potassium channel family. (568 aa) |
| | FAM124B | Family with sequence similarity 124 member B. (454 aa) |
| | CFL1 | Cofilin-1; Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up- regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration (By similarity). (179 aa) |
| | SRPX | Sushi repeat containing protein X-linked. (461 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (533 aa) |
| | LOC100626157 | Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (175 aa) |
| | K7GLG1_PIG | Uncharacterized protein. (449 aa) |
| | ACE2 | Angiotensin-converting enzyme. (805 aa) |
| | CDC42 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (197 aa) |
| | AGT | Angiotensinogen; Belongs to the serpin family. (482 aa) |
| | ICAM1 | Intercellular adhesion molecule 1. (537 aa) |
| | S100A10 | Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. (97 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa) |
| | IL13RA2 | Interleukin 13 receptor subunit alpha 2. (387 aa) |
| | FHL1 | Four and a half LIM domains 1. (450 aa) |
| | ESR1 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa) |
| | CLTRN | Collectrin. (247 aa) |
| | CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (177 aa) |
| | SCAF11 | SR-related CTD associated factor 11. (1398 aa) |
| | EYA2 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (583 aa) |
| | ARNTL2 | Aryl hydrocarbon receptor nuclear translocator like 2. (652 aa) |
| | CYBRD1 | Cytochrome b reductase 1 isoform 1. (285 aa) |
| | KCNB1 | Potassium voltage-gated channel subfamily B member 1; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Plays also a role in the regulation of exocytosis independently of its electrical function. Forms [...] (858 aa) |
| | SYNPO | Synaptopodin. (883 aa) |
| | PRL | Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation. (229 aa) |
| | LOC110258125 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa) |
| | KCNMA1 | Calcium-activated potassium channel subunit alpha-1; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in t [...] (1288 aa) |
| | ZNF335 | Zinc finger protein 335. (1354 aa) |
| | KRT4 | Keratin 4; Belongs to the intermediate filament family. (533 aa) |
| | PAX6 | Paired box 6. (498 aa) |
| | NTAN1 | Protein N-terminal asparagine amidohydrolase; N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by NTAN1/PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as spec [...] (374 aa) |
| | NUP88 | Nucleoporin 88. (739 aa) |
| | DNAJC13 | DnaJ heat shock protein family (Hsp40) member C13. (2248 aa) |
| | HAS3 | Hyaluronan synthase 3 isoform a. (553 aa) |
| | SLCO4A1 | Solute carrier organic anion transporter family member. (829 aa) |
| | KLK5 | Kallikrein related peptidase 5; Belongs to the peptidase S1 family. (295 aa) |
| | RXFP1 | Relaxin family peptide receptor 1. (785 aa) |
| | SIAH1 | E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (313 aa) |
| | GAPDH | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (398 aa) |
| | ACTB | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa) |
| | SLC17A9 | Solute carrier family 17 member 9. (600 aa) |
| | OR10J5 | Olfactory receptor family 10 subfamily J member 5. (309 aa) |
| | CFTR | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1482 aa) |
| | SLC11A2 | Solute carrier family 11 member 2. (596 aa) |
| | NPHS1 | NPHS1 adhesion molecule, nephrin. (1239 aa) |
| | LAMC1 | Uncharacterized protein. (1607 aa) |
| | EFNB2 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. (335 aa) |
| | ATF7 | Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (494 aa) |
| | IL11 | Interleukin 11. (199 aa) |
| | CLDN1 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa) |
| | KRT80 | Keratin, type II cytoskeletal 80 isoform K80; Belongs to the intermediate filament family. (452 aa) |
| | ACTBL2 | Actin beta like 2. (385 aa) |
| | LOC110258582 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (245 aa) |
| | TMEM11 | Transmembrane protein 11. (292 aa) |
| | ITGA10 | Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1352 aa) |
| | GCNT2 | Glucosaminyl (N-acetyl) transferase 2 (I blood group). (402 aa) |
| | KLK6 | Kallikrein related peptidase 6; Belongs to the peptidase S1 family. (246 aa) |
| | ABHD2 | Abhydrolase domain containing 2. (453 aa) |
| | OVGP1 | Oviduct-specific glycoprotein; Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development. (519 aa) |
| | AQP4 | Aquaporin-4 isoform M1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (323 aa) |
| | GKN3 | Gastrokine-3; May inhibit gastric epithelial cell proliferation. Belongs to the gastrokine family. (170 aa) |
| | ACTG1 | Actin gamma 1. (381 aa) |
| | RLBP1 | Retinaldehyde binding protein 1. (384 aa) |
| | DISP1 | Dispatched RND transporter family member 1. (1590 aa) |
| | HAMP | Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity). Belongs to the hepcidin family. (82 aa) |
| | TMPRSS2 | Transmembrane serine protease 2; Belongs to the peptidase S1 family. (526 aa) |
| | GPBAR1 | G protein-coupled bile acid receptor 1. (329 aa) |
| | IL1B-2 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (244 aa) |
| | GPX1 | Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown. (205 aa) |
| | KRT7 | Keratin 7; Belongs to the intermediate filament family. (468 aa) |
| | CD46 | Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. (381 aa) |
| | EDN1 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (203 aa) |
| | GABPB1 | GA binding protein transcription factor subunit beta 1. (360 aa) |
| | LOC110258579 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (272 aa) |
| | OCLN | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (533 aa) |
| | PECAM1 | Platelet endothelial cell adhesion molecule; Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-692 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutr [...] (740 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (267 aa) |
| | GRINA | Glutamate ionotropic receptor NMDA type subunit associated protein 1. (356 aa) |
| | PPGRP-S | Uncharacterized protein. (424 aa) |
| | MUC5AC | Uncharacterized protein. (3330 aa) |
| | KLF5 | Uncharacterized protein. (457 aa) |
| | REN | Renin preproprotein; Belongs to the peptidase A1 family. (407 aa) |
| | ERCC3 | ERCC excision repair 3, TFIIH core complex helicase subunit. (801 aa) |
| | LOC100624085 | G_PROTEIN_RECEP_F1_2 domain-containing protein. (309 aa) |
| | EYA4 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (645 aa) |
| | KRT8 | Keratin, type II cytoskeletal 8 isoform 2; Belongs to the intermediate filament family. (461 aa) |
| | CDH5 | Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (By similarity). Acts in concert with KRIT1 and MPP5 to establish and maintain correct endotheli [...] (782 aa) |
| | FAM222B | Family with sequence similarity 222 member B. (564 aa) |
| | ARHGEF26 | Rho guanine nucleotide exchange factor 26. (872 aa) |
| | ESS2 | Ess-2 splicing factor homolog. (521 aa) |
| | SDC4 | Syndecan-4; Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP. Belongs to the syndecan proteoglycan family. (353 aa) |
| | SPDEF | SAM pointed domain containing ETS transcription factor. (363 aa) |
| | CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). (266 aa) |
| | TSEN34 | tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...] (350 aa) |
| | PDSS1 | Decaprenyl diphosphate synthase subunit 1; Belongs to the FPP/GGPP synthase family. (409 aa) |
| | LOC110255300 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa) |
| | NET1 | Neuroepithelial cell transforming 1. (574 aa) |
| | ECSCR | Uncharacterized protein. (238 aa) |
| | HHIP | Hedgehog-interacting protein. (700 aa) |
| | POU4F1 | POU domain protein. (421 aa) |
| | A0A287BA99_PIG | ATP-synt_C domain-containing protein; Belongs to the V-ATPase proteolipid subunit family. (81 aa) |
| | TSHR | Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. (764 aa) |
| | SHISA3 | Shisa family member 3. (337 aa) |
| | TJP1 | Tight junction protein 1; Belongs to the MAGUK family. (1862 aa) |
| | PGLYRP3 | Uncharacterized protein. (378 aa) |
| | LGR5 | Leucine-rich repeat-containing G-protein coupled receptor 5 isoform 1. (907 aa) |
| | PRPSAP2 | Sodium/glucose cotransporter 5; High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (876 aa) |
| | INPP4B | Inositol polyphosphate-4-phosphatase type II B. (938 aa) |
| | A0A287BMQ8_PIG | C3H1-type domain-containing protein. (218 aa) |
| | NKX3-1 | Homeobox protein Nkx-3.1 isoform 1. (247 aa) |
| | CSDE1 | Cold shock domain containing E1. (851 aa) |
| | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha isoform 1. (184 aa) |
| | TACC2 | Uncharacterized protein. (2041 aa) |
| | LOC110259119 | Uncharacterized protein. (674 aa) |
| | ADCY3 | Adenylate cyclase 3. (1320 aa) |
| | LOC110259156 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa) |
| | KCNJ2 | Inward rectifier potassium channel 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be bl [...] (427 aa) |
| | PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa) |
| | THBD | Uncharacterized protein. (529 aa) |
| | ANXA8 | Annexin. (354 aa) |
| | AIG1 | Androgen induced 1. (315 aa) |
| | CLDN5 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa) |
| | OMP | Uncharacterized protein. (292 aa) |
| | TLR4 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (841 aa) |
| | ISM1 | Isthmin 1. (595 aa) |
| | LOC100155689 | G_PROTEIN_RECEP_F1_2 domain-containing protein. (309 aa) |
| | NTF4 | Neurotrophin 4; Belongs to the NGF-beta family. (210 aa) |
| | CHST1 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (411 aa) |
| | KCNS3 | Potassium voltage-gated channel subfamily S member 3 isoform X1; Belongs to the potassium channel family. (491 aa) |
| | SPINK5 | Serine peptidase inhibitor, Kazal type 5. (1023 aa) |
| | ENAM | 142 kDa enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation. (1142 aa) |
| | DDX4 | Probable ATP-dependent RNA helicase DDX4; ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycl [...] (744 aa) |
| | LOC106510284 | Uncharacterized protein. (356 aa) |
| | A0A5G2QIP1_PIG | G_PROTEIN_RECEP_F1_2 domain-containing protein. (315 aa) |
| | ANPEP | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization (By similarity). It is able to degrade Leu-enkephalin and Met [...] (1017 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa) |
| | PRSS8 | Serine protease 8; Belongs to the peptidase S1 family. (344 aa) |
| | ASGR1 | Asialoglycoprotein receptor 1. (332 aa) |
| | FBN2 | Fibrillin 2. (2910 aa) |
| | SELL | Selectin L. (399 aa) |
| | LOC100519710 | G_PROTEIN_RECEP_F1_2 domain-containing protein. (313 aa) |
| | FFAR2-L | Free fatty acid receptor 2-like receptor; Belongs to the G-protein coupled receptor 1 family. (329 aa) |
| | MUC2 | Uncharacterized protein. (3289 aa) |
| | GLIPR2 | GLI pathogenesis related 2; Belongs to the CRISP family. (203 aa) |
| | KRT18 | Keratin 18; Belongs to the intermediate filament family. (423 aa) |
| | ATP6V0C | V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa) |
| | TG | Thyroglobulin; Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling. Following TG re-internalization and lysosomal- mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (By similarity); Belongs to the type-B carboxylesterase/lipase family. (2727 aa) |
| | CLEC4G | C-type lectin domain-containing protein. (358 aa) |
| | LOC100627086 | G_PROTEIN_RECEP_F1_2 domain-containing protein. (313 aa) |
| | CLCN4 | Chloride channel protein. (758 aa) |
| | ATP4A | Potassium-transporting ATPase alpha chain 1; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach. (1041 aa) |
| | UPK1A | Uncharacterized protein; Belongs to the tetraspanin (TM4SF) family. (284 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (411 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1085 aa) |
| | AFM | Afamin. (612 aa) |
| | SLC5A2 | Solute carrier family 5 member 2; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (674 aa) |
| | AMELY | Amelogenin; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family. (189 aa) |
| | HERPUD2 | HERPUD family member 2. (435 aa) |
| | LTBP2 | Latent transforming growth factor beta binding protein 2. (1814 aa) |
| | CPSF4 | Cleavage and polyadenylation specific factor 4. (293 aa) |
| | MMP2 | Uncharacterized protein. (610 aa) |
| | CD2AP | CD2 associated protein. (643 aa) |
| | CMPK2 | Cytidine/uridine monophosphate kinase 2. (449 aa) |
| | TMEM53 | Transmembrane protein 53. (278 aa) |
| | TPO | Thyroid peroxidase; Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4). Belongs to the peroxidase family. XPO subfamily. (911 aa) |
