STRINGSTRING
RPS13 RPS13 F1SRB7_PIG F1SRB7_PIG TPI1 TPI1 MEA1 MEA1 ABCC10 ABCC10 ADGRF1 ADGRF1 C14orf119 C14orf119 GPX2 GPX2 F1RNZ2_PIG F1RNZ2_PIG FUT2 FUT2 GUCA2B GUCA2B VIP VIP CKMT1A CKMT1A PLA2G4F PLA2G4F TMEM260 TMEM260 SLC1A1 SLC1A1 TRPM6 TRPM6 PIGO PIGO DCAF10 DCAF10 ALDH9A1 ALDH9A1 MTMR11 MTMR11 CD58 CD58 VDAC3 VDAC3 MICALL2 MICALL2 BRAT1 BRAT1 ATP5MF ATP5MF FABP1 FABP1 LOC100520832 LOC100520832 ANXA4 ANXA4 F1SQI2_PIG F1SQI2_PIG LOC100523732 LOC100523732 RPL34 RPL34 MTTP MTTP WDFY3 WDFY3 OLFM4 OLFM4 SLC15A1 SLC15A1 ADAMDEC1 ADAMDEC1 SLC5A1 SLC5A1 SLC5A4 SLC5A4 CSGALNACT2 CSGALNACT2 NKX2-3 NKX2-3 NUDT2 NUDT2 LOC100627129 LOC100627129 CCK CCK ARL14 ARL14 MUC13 MUC13 RETNLB RETNLB APP APP Z4YP56_PIG Z4YP56_PIG S100G S100G POF1B POF1B CAPN1 CAPN1 EEF1G EEF1G SLC39A13 SLC39A13 TRAPPC5 TRAPPC5 CALR CALR OCEL1 OCEL1 SORBS2 SORBS2 TLR3 TLR3 GCG GCG VIL1 VIL1 TM4SF20 TM4SF20 PPIA PPIA NPC1L1 NPC1L1 FABP6 FABP6 ENDOV ENDOV MRM1 MRM1 C17orf78 C17orf78 CD4 CD4 TXNDC15 TXNDC15 RPL18 RPL18 SLC10A2 SLC10A2 ACTL8 ACTL8 FAM172A FAM172A I3L8K3_PIG I3L8K3_PIG CCT6A CCT6A RPS21 RPS21 LGALS2 LGALS2 ZNF507 ZNF507 CSTB CSTB RPS9 RPS9 CYP3A22 CYP3A22 FAM13A FAM13A ATP5IF1 ATP5IF1 PYY PYY SI SI IL6 IL6 MAFF MAFF TFF3 TFF3 TFF2 TFF2 MFSD14A MFSD14A FBXL19 FBXL19 CCT6B CCT6B RPS16 RPS16 SLC30A2 SLC30A2 MAMDC2 MAMDC2 BATF2 BATF2 CFL1 CFL1 TMSB4X TMSB4X CCL5 CCL5 TFRC TFRC FAM160A2 FAM160A2 FAP FAP REG3G REG3G MS4A10 MS4A10 VSIG10 VSIG10 MRPS7 MRPS7 CTNNB1 CTNNB1 RPL15 RPL15 CYBRD1 CYBRD1 A0A286ZPT4_PIG A0A286ZPT4_PIG SLC17A2 SLC17A2 RPL10 RPL10 LOC110257905 LOC110257905 GAPDH GAPDH ACTB ACTB A0A286ZVF0_PIG A0A286ZVF0_PIG A0A286ZVX2_PIG A0A286ZVX2_PIG MS4A12 MS4A12 SUCLG2 SUCLG2 RPS19 RPS19 CFTR CFTR MLLT6 MLLT6 SLC11A2 SLC11A2 MGAM MGAM CLCA1 CLCA1 CLDN1 CLDN1 U2AF1L4 U2AF1L4 PSMB8 PSMB8 AOC1 AOC1 GREM1 GREM1 MGAM2 MGAM2 A0A287A343_PIG A0A287A343_PIG KLHL15 KLHL15 ACTBL2 ACTBL2 RPL23 RPL23 ATG16L1 ATG16L1 PRDX2 PRDX2 A0A287A6V0_PIG A0A287A6V0_PIG RPL31 RPL31 RBKS RBKS RPLP0 RPLP0 LOC751868 LOC751868 FABP2 FABP2 NUFIP1 NUFIP1 LOC102159834 LOC102159834 ACTG1 ACTG1 A0A287ABD6_PIG A0A287ABD6_PIG PIGR PIGR HAMP HAMP SCIN SCIN ZNF248 ZNF248 A0A287AF12_PIG A0A287AF12_PIG FUT2A FUT2A DDOST DDOST TTC38 TTC38 A0A287AH51_PIG A0A287AH51_PIG U2AF1 U2AF1 MAGI3 MAGI3 OCLN OCLN PPP1R37 PPP1R37 RPS15 RPS15 NRF1 NRF1 RPL29 RPL29 RPL27A RPL27A A0A287AQP3_PIG A0A287AQP3_PIG A0A287ARH8_PIG A0A287ARH8_PIG URM1 URM1 HOOK3 HOOK3 RSPO1 RSPO1 COX17 COX17 ITLN2 ITLN2 SPAI-2 SPAI-2 FAM3C FAM3C ANKRD9 ANKRD9 GAL GAL CD300LF CD300LF PSMB4 PSMB4 BCS1L BCS1L B2M B2M CLIC1 CLIC1 PNLIPRP2 PNLIPRP2 PDSS1 PDSS1 PLBD1 PLBD1 B3GNT5 B3GNT5 SST SST RPL3 RPL3 TSPAN31 TSPAN31 RPLP2 RPLP2 NSUN4 NSUN4 RPL13A RPL13A TMEM139 TMEM139 CDC42EP4 CDC42EP4 STXBP2 STXBP2 PAQR8 PAQR8 A0A287BCR5_PIG A0A287BCR5_PIG DAG1 DAG1 RPL32 RPL32 LGR5 LGR5 PRPSAP2 PRPSAP2 GOT2 GOT2 B3GALNT1 B3GALNT1 SMTNL1 SMTNL1 ZNF644 ZNF644 NOD2 NOD2 UVSSA UVSSA VILL VILL CYP2C36 CYP2C36 SLC38A6 SLC38A6 RPL21 RPL21 ATP5F1A ATP5F1A SLC7A9 SLC7A9 A0A287BRW3_PIG A0A287BRW3_PIG RPL10A RPL10A DHX35 DHX35 RPL11 RPL11 ANXA8 ANXA8 ERLIN2 ERLIN2 CSNK1A1 CSNK1A1 TLR4 TLR4 RPL4 RPL4 AURKB AURKB A0A5G2QBW0_PIG A0A5G2QBW0_PIG FUT1 FUT1 DENND1C DENND1C APOC3 APOC3 RPL35 RPL35 CAPZA2 CAPZA2 ANPEP ANPEP A0A5G2QIT2_PIG A0A5G2QIT2_PIG CLDN3 CLDN3 LGALS4 LGALS4 PPP1R1B PPP1R1B TRPC4 TRPC4 A0A5G2QUR2_PIG A0A5G2QUR2_PIG TMIGD1 TMIGD1 LEAP2 LEAP2 PAQR7 PAQR7 RPL5 RPL5 BANK1 BANK1 RNF121 RNF121 TLR2 TLR2 HHLA2 HHLA2 RPL7A RPL7A A0A5G2QU22_PIG A0A5G2QU22_PIG GNLY GNLY TMPRSS15 TMPRSS15 SNRPD2 SNRPD2 SLC17A4 SLC17A4 A0A5G2QXY3_PIG A0A5G2QXY3_PIG DHX37 DHX37 MDH2 MDH2 RALGPS1 RALGPS1 ABCE1 ABCE1 SMARCD2 SMARCD2 MFSD1 MFSD1 CKB CKB ADAT2 ADAT2 HAUS6 HAUS6 RPA2 RPA2 COG4 COG4 WDR83OS WDR83OS CLDN4 CLDN4 ATP5F1D ATP5F1D NDUFB6 NDUFB6 NAALADL1 NAALADL1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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RPS1340S ribosomal protein S13; Belongs to the universal ribosomal protein uS15 family. (213 aa)
F1SRB7_PIGUncharacterized protein. (125 aa)
TPI1Triosephosphate isomerase; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. (285 aa)
MEA1Male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development. (196 aa)
ABCC10ATP binding cassette subfamily C member 10. (1490 aa)
ADGRF1Adhesion G-protein coupled receptor F1 isoform 1; Belongs to the G-protein coupled receptor 2 family. (927 aa)
C14orf119Chromosome 14 open reading frame 119. (165 aa)
GPX2Glutathione peroxidase; Belongs to the glutathione peroxidase family. (190 aa)
F1RNZ2_PIGUncharacterized protein; Belongs to the eukaryotic ribosomal protein P1/P2 family. (115 aa)
FUT2Galactoside 2-alpha-L-fucosyltransferase 2; Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids. The resulting epitope plays a role in cell-cell interaction including host-microbe interaction (By similarity). Mediates interaction with intestinal microbiota influencing its composition (By similarity). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen, which is an essential substrate for the final step in the membrane-associated blood group antigen synthesis pathway (By similarity). (340 aa)
GUCA2BGuanylate cyclase activator 2B; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport (By similarity); Belongs to the guanylin family. (113 aa)
VIPVasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder; Belongs to the glucagon family. (167 aa)
CKMT1ACreatine kinase U-type, mitochondrial; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity). (416 aa)
PLA2G4FPhospholipase A2. (852 aa)
TMEM260Transmembrane protein 260 isoform X1. (707 aa)
SLC1A1Amino acid transporter. (524 aa)
TRPM6Transient receptor potential cation channel subfamily M member 6. (2027 aa)
PIGOPhosphatidylinositol glycan anchor biosynthesis class O. (1131 aa)
DCAF10DDB1-and CUL4-associated factor 10 isoform X1. (562 aa)
ALDH9A14-trimethylaminobutyraldehyde dehydrogenase; Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. (596 aa)
MTMR11Myotubularin phosphatase domain-containing protein. (700 aa)
CD58Uncharacterized protein. (243 aa)
VDAC3Voltage-dependent anion-selective channel protein 3; Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules; Belongs to the eukaryotic mitochondrial porin family. (284 aa)
MICALL2MICAL-like protein 2 isoform X1. (887 aa)
BRAT1BRCA1-associated ATM activator 1 isoform 2. (822 aa)
ATP5MFATP synthase subunit f, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the centr [...] (185 aa)
FABP1Fatty acid-binding protein, liver; Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes. Binds cholesterol. Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (151 aa)
LOC100520832C-type lectin domain-containing protein. (176 aa)
ANXA4Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis; Belongs to the annexin family. (337 aa)
F1SQI2_PIGUncharacterized protein. (135 aa)
LOC100523732Uncharacterized protein. (460 aa)
RPL3460S ribosomal protein L34; Component of the large ribosomal subunit. (117 aa)
MTTPMicrosomal triglyceride transfer protein large subunit; Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. (894 aa)
WDFY3WD repeat and FYVE domain containing 3. (3526 aa)
OLFM4Olfactomedin 4. (488 aa)
SLC15A1Peptide transporter 1. (708 aa)
ADAMDEC1ADAM like decysin 1. (454 aa)
SLC5A1Sodium/glucose cotransporter 1; Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. (690 aa)
SLC5A4Solute carrier family 5 member 4; Has electrogenic activity in response to glucose, and may function as a glucose sensor. Also has low-affinity sodium/glucose cotransporter activity; sugar transport activity is tightly coupled to ion transport at neutral pH but is reduced under more acidic conditions. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (659 aa)
CSGALNACT2Hexosyltransferase. (542 aa)
NKX2-3NK2 homeobox 3. (367 aa)
NUDT2Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis. (147 aa)
LOC100627129Uncharacterized protein. (129 aa)
CCKCholecystokinin-58 desnonopeptide; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. (154 aa)
ARL14ADP ribosylation factor like GTPase 14; Belongs to the small GTPase superfamily. Arf family. (192 aa)
MUC13Uncharacterized protein. (537 aa)
RETNLBResistin-like beta protein. (111 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (756 aa)
Z4YP56_PIGUncharacterized protein. (79 aa)
S100GProtein S100-G, minor isoform; Belongs to the S-100 family. (108 aa)
POF1BPOF1B actin binding protein. (589 aa)
CAPN1Calpain-1 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. (775 aa)
EEF1GElongation factor 1-gamma; Probably plays a role in anchoring the complex to other cellular components. (436 aa)
SLC39A13Zinc transporter SLC39A7; Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol; Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily. (372 aa)
TRAPPC5Trafficking protein particle complex subunit 5; May play a role in vesicular transport from endoplasmic reticulum to Golgi. (188 aa)
CALRCalreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis; Belongs to the calreticulin family. (417 aa)
OCEL1Occludin/ELL domain containing 1. (258 aa)
SORBS2Sorbin and SH3 domain-containing protein 2; Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1 (By similarity). May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12. Increases water and sodium absorption in the intestine [...] (1432 aa)
TLR3TIR domain-containing protein; Belongs to the Toll-like receptor family. (903 aa)
GCGGlicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] (180 aa)
VIL1Villin-1; Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the inte [...] (826 aa)
TM4SF20Transmembrane 4 L six family member 20. (227 aa)
PPIAPeptidyl-prolyl cis-trans isomerase A, N-terminally processed; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding; Belongs to the cyclophilin-type PPIase family. PPIase A subfamily. (160 aa)
NPC1L1NPC1-like intracellular cholesterol transporter 1 isoform 2. (1332 aa)
FABP6Gastrotropin; Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). Stimulates gastric acid and pepsinogen secretion. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (143 aa)
ENDOVEndonuclease V. (250 aa)
MRM1Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (396 aa)
C17orf78Chromosome 17 open reading frame 78. (287 aa)
CD4CD4 molecule. (494 aa)
TXNDC15Thioredoxin domain-containing protein. (352 aa)
RPL1860S ribosomal protein L18; Component of the large ribosomal subunit. (219 aa)
SLC10A2Uncharacterized protein. (353 aa)
ACTL8Actin like 8; Belongs to the actin family. (365 aa)
FAM172AFamily with sequence similarity 172 member A. (416 aa)
I3L8K3_PIGUncharacterized protein. (170 aa)
CCT6AT-complex protein 1 subunit zeta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity). (531 aa)
RPS2140S ribosomal protein S21; Belongs to the eukaryotic ribosomal protein eS21 family. (83 aa)
LGALS2Galectin-2; This protein binds beta-galactoside. Its physiological function is not yet known (By similarity). (144 aa)
ZNF507Zinc finger protein 507. (1002 aa)
CSTBCystatin-B; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family. (98 aa)
RPS940S ribosomal protein S9; Belongs to the universal ribosomal protein uS4 family. (194 aa)
CYP3A22Cytochrome P450 3A29; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (667 aa)
FAM13AFamily with sequence similarity 13 member A. (1020 aa)
ATP5IF1ATPase inhibitor, mitochondrial; Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron i [...] (108 aa)
PYYPeptide YY(3-36); This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility. (174 aa)
SISucrase-isomaltase, intestinal; Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides (By similarity). (1546 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
MAFFMAF bZIP transcription factor F. (166 aa)
TFF3Trefoil factor 3; Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen) (By similarity). (109 aa)
TFF2Trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. (165 aa)
MFSD14AMFS domain-containing protein. (453 aa)
FBXL19F-box and leucine rich repeat protein 19. (694 aa)
CCT6BChaperonin containing TCP1 subunit 6B. (625 aa)
RPS1640S ribosomal protein S16; Belongs to the universal ribosomal protein uS9 family. (151 aa)
SLC30A2Uncharacterized protein. (347 aa)
MAMDC2MAM domain containing 2. (685 aa)
BATF2Basic leucine zipper transcriptional factor ATF-like 2 isoform 1. (276 aa)
CFL1Cofilin-1; Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up- regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration (By similarity). (179 aa)
TMSB4XHematopoietic system regulatory peptide; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization; Belongs to the thymosin beta family. (44 aa)
CCL5C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa)
TFRCTransferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). (794 aa)
FAM160A2Family with sequence similarity 160 member A2. (985 aa)
FAPFibroblast activation protein alpha; Belongs to the peptidase S9B family. (760 aa)
REG3GLithostathine A chain; Might act as an inhibitor of spontaneous calcium carbonate precipitation. (176 aa)
MS4A10Membrane spanning 4-domains A10. (236 aa)
VSIG10V-set and immunoglobulin domain containing 10. (536 aa)
MRPS728S ribosomal protein S7, mitochondrial. (242 aa)
CTNNB1Catenin beta 1. (808 aa)
RPL1560S ribosomal protein L15. (204 aa)
CYBRD1Cytochrome b reductase 1 isoform 1. (285 aa)
A0A286ZPT4_PIGUncharacterized protein. (71 aa)
SLC17A2Sodium-dependent phosphate transport protein 3 isoform a. (478 aa)
RPL1060S ribosomal protein L10; Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. (329 aa)
LOC110257905Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (398 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
A0A286ZVF0_PIGUncharacterized protein. (174 aa)
A0A286ZVX2_PIGUncharacterized protein. (88 aa)
MS4A12Membrane spanning 4-domains A12. (258 aa)
SUCLG2Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (457 aa)
RPS1940S ribosomal protein S19; Required for pre-rRNA processing and maturation of 40S ribosomal subunits; Belongs to the eukaryotic ribosomal protein eS19 family. (196 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1482 aa)
MLLT6MLLT6, PHD finger containing. (1093 aa)
SLC11A2Solute carrier family 11 member 2. (596 aa)
MGAMMaltase-glucoamylase, intestinal. (1826 aa)
CLCA1Calcium-activated chloride channel regulator 1; May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. Induces a cAMP-dependent chloride conductance possibly through effects on CFTR in colon carcinoma cells. Belongs to the CLCR family. (915 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
U2AF1L4Splicing factor U2AF 35 kDa subunit-like protein isoform 2. (247 aa)
PSMB8Proteasome subunit beta type-8; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. May participate in the generation of spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein (By similarity). Required for adip [...] (295 aa)
AOC1Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis; Belongs to the copper/topaquinone oxidase family. (726 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (240 aa)
MGAM2Maltase-glucoamylase 2 (putative). (2506 aa)
A0A287A343_PIGPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (164 aa)
KLHL15Kelch like family member 15. (614 aa)
ACTBL2Actin beta like 2. (385 aa)
RPL2360S ribosomal protein L23; Belongs to the universal ribosomal protein uL14 family. (140 aa)
ATG16L1Autophagy-related protein 16-1 isoform X1. (623 aa)
PRDX2Peroxiredoxin-2; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2); Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (237 aa)
A0A287A6V0_PIGUncharacterized protein. (155 aa)
RPL3160S ribosomal protein L31; Belongs to the eukaryotic ribosomal protein eL31 family. (129 aa)
RBKSRibokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (323 aa)
RPLP060S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (322 aa)
LOC751868Ribosomal_L18e/L15P domain-containing protein. (137 aa)
FABP2Fatty acid-binding protein, intestinal; FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor (By similarity). (132 aa)
NUFIP1Nuclear fragile X mental retardation-interacting protein 1. (494 aa)
LOC102159834Uncharacterized protein; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (680 aa)
ACTG1Actin gamma 1. (381 aa)
A0A287ABD6_PIGRibosomal_L18e/L15P domain-containing protein. (167 aa)
PIGRPolymeric immunoglobulin receptor; This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface (By similarity). (792 aa)
HAMPHepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity). Belongs to the hepcidin family. (82 aa)
SCINAdseverin; Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Severing activity is inhibited by phosphatidylinositol 4,5-bis- phosphate (PIP2) (By similarity). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (By similarity). Plays a role in osteoclastogenesis (OCG) and actin cytoskel [...] (715 aa)
ZNF248Zinc finger protein 248 isoform 1. (580 aa)
A0A287AF12_PIGUncharacterized protein. (155 aa)
FUT2AL-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (404 aa)
DDOSTDolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across t [...] (437 aa)
TTC38Tetratricopeptide repeat domain 38. (490 aa)
A0A287AH51_PIGPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (163 aa)
U2AF1Splicing factor U2AF 35 kDa subunit; Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron (By similarity). (239 aa)
MAGI3Membrane associated guanylate kinase, WW and PDZ domain containing 3. (1464 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (533 aa)
PPP1R37Protein phosphatase 1 regulatory subunit 37. (695 aa)
RPS1540S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family. (145 aa)
NRF1Nuclear respiratory factor 1 isoform 1. (503 aa)
RPL2960S ribosomal protein L29; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL29 family. (255 aa)
RPL27A60S ribosomal protein L27a. (211 aa)
A0A287AQP3_PIGUncharacterized protein; Belongs to the universal ribosomal protein uS19 family. (147 aa)
A0A287ARH8_PIGRibosomal_S13_N domain-containing protein. (73 aa)
URM1Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for co [...] (200 aa)
HOOK3Hook microtubule tethering protein 3. (786 aa)
RSPO1R-spondin 1. (262 aa)
COX17Cytochrome c oxidase copper chaperone; Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2). (63 aa)
ITLN2Intelectin 2. (388 aa)
SPAI-2Sodium/potassium ATPase inhibitor SPAI-2; Inhibits Na(+),K(+) ATPase by the competitive mode against Na(+). (187 aa)
FAM3CFamily with sequence similarity 3 member C. (227 aa)
ANKRD9Uncharacterized protein. (360 aa)
GALGalanin message-associated peptide; Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion; Belongs to the galanin family. (337 aa)
CD300LFIg-like domain-containing protein. (301 aa)
PSMB4Proteasome subunit beta type-4; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] (264 aa)
BCS1LBCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone; Belongs to the AAA ATPase family. (419 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (157 aa)
CLIC1Chloride intracellular channel protein 1; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions (By similarity). (248 aa)
PNLIPRP2Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (574 aa)
PDSS1Decaprenyl diphosphate synthase subunit 1; Belongs to the FPP/GGPP synthase family. (409 aa)
PLBD1Heat-stable enterotoxin receptor; Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin (By similarity); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1075 aa)
B3GNT5Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase; Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Plays a central role in regulating neolacto-series glycolipid synthesis during embryonic de [...] (377 aa)
SSTSomatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin. (116 aa)
RPL360S ribosomal protein L3; The L3 protein is a component of the large subunit of cytoplasmic ribosomes. (403 aa)
TSPAN31Tetraspanin-31. (280 aa)
RPLP260S acidic ribosomal protein P2; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family. (115 aa)
NSUN4NOP2/Sun RNA methyltransferase 4; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (382 aa)
RPL13A60S ribosomal protein L13a; Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppres [...] (500 aa)
TMEM139Transmembrane protein 139. (209 aa)
CDC42EP4CDC42 effector protein 4. (357 aa)
STXBP2Syntaxin-binding protein 2; Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells (By similarity); Belongs to the STXBP/unc-18/SEC1 family. (650 aa)
PAQR8Membrane progestin receptor beta; Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation (By similarity); Belongs to the ADIPOR family. (387 aa)
A0A287BCR5_PIGUncharacterized protein; Belongs to the universal ribosomal protein uL14 family. (135 aa)
DAG1Alpha-dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non- muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell ad [...] (912 aa)
RPL3260S ribosomal protein L32; Belongs to the eukaryotic ribosomal protein eL32 family. (135 aa)
LGR5Leucine-rich repeat-containing G-protein coupled receptor 5 isoform 1. (907 aa)
PRPSAP2Sodium/glucose cotransporter 5; High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (876 aa)
GOT2Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). (442 aa)
B3GALNT1UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1; Transfers N-acetylgalactosamine onto globotriaosylceramide. Plays a critical role in preimplantation stage embryonic development. (331 aa)
SMTNL1Calponin-homology (CH) domain-containing protein. (182 aa)
ZNF644Zinc finger protein 644. (1368 aa)
NOD2Uncharacterized protein. (1013 aa)
UVSSAUV stimulated scaffold protein A. (821 aa)
VILLVillin like. (854 aa)
CYP2C36Cytochrome P450 2C42; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (843 aa)
SLC38A6Solute carrier family 38 member 6. (463 aa)
RPL2160S ribosomal protein L21; Component of the large ribosomal subunit. (160 aa)
ATP5F1AATP synthase subunit alpha, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...] (737 aa)
SLC7A9Solute carrier family 7 member 9. (562 aa)
A0A287BRW3_PIGRibosomal protein L15; Belongs to the eukaryotic ribosomal protein eL15 family. (188 aa)
RPL10A60S ribosomal protein L10a; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL1 family. (219 aa)
DHX35Putative ATP-dependent RNA helicase DHX35 isoform 1. (732 aa)
RPL1160S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (192 aa)
ANXA8Annexin. (354 aa)
ERLIN2ER lipid raft associated 2. (384 aa)
CSNK1A1Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration. (359 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (841 aa)
RPL460S ribosomal protein L4; Belongs to the universal ribosomal protein uL4 family. (449 aa)
AURKBAurora kinase B; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of [...] (443 aa)
A0A5G2QBW0_PIGRibosomal_L18e/L15P domain-containing protein. (152 aa)
FUT1Galactoside 2-alpha-L-fucosyltransferase 1; Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Gal-beta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. (364 aa)
DENND1CDENN domain containing 1C. (818 aa)
APOC3Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tigh [...] (199 aa)
RPL3560S ribosomal protein L35; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL29 family. (123 aa)
CAPZA2F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity). (286 aa)
ANPEPAminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization (By similarity). It is able to degrade Leu-enkephalin and Met [...] (1017 aa)
A0A5G2QIT2_PIGUncharacterized protein. (132 aa)
CLDN3Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (139 aa)
LGALS4Galectin-4; Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions. (321 aa)
PPP1R1BProtein phosphatase 1 regulatory subunit 1B; Inhibitor of protein-phosphatase 1. (200 aa)
TRPC4Transient receptor potential cation channel subfamily C member 4; Belongs to the transient receptor (TC 1.A.4) family. (982 aa)
A0A5G2QUR2_PIGUncharacterized protein. (102 aa)
TMIGD1Transmembrane and immunoglobulin domain containing 1. (395 aa)
LEAP2Liver-expressed antimicrobial peptide 2; Has an antimicrobial activity; Belongs to the LEAP2 family. (112 aa)
PAQR7Membrane progestin receptor alpha; Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway. May be involved in oocyte maturation. Involved in neurosteroid inhibition of apoptosis. Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone. (350 aa)
RPL560S ribosomal protein L5; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (299 aa)
BANK1B cell scaffold protein with ankyrin repeats 1. (780 aa)
RNF121Ring finger protein 121. (328 aa)
TLR2Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
HHLA2HERV-H LTR-associating 2. (408 aa)
RPL7A60S ribosomal protein L7a. (334 aa)
A0A5G2QU22_PIGUncharacterized protein. (147 aa)
GNLYAntimicrobial peptide NK-lysin; May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans. (210 aa)
TMPRSS15Enteropeptidase non-catalytic heavy chain; Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases. (1049 aa)
SNRPD2Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (140 aa)
SLC17A4Solute carrier family 17 member 4. (558 aa)
A0A5G2QXY3_PIGUncharacterized protein. (126 aa)
DHX37DEAH-box helicase 37. (1186 aa)
MDH2Malate dehydrogenase, mitochondrial. (395 aa)
RALGPS1Ral GEF with PH domain and SH3 binding motif 1. (604 aa)
ABCE1ATP binding cassette subfamily E member 1. (589 aa)
SMARCD2SWIB domain-containing protein. (499 aa)
MFSD1Major facilitator superfamily domain-containing protein 1. (468 aa)
CKBCreatine kinase B-type; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa; Belongs to the ATP:guanido phosphotransferase family. (403 aa)
ADAT2Adenosine deaminase tRNA specific 2. (230 aa)
HAUS6HAUS augmin like complex subunit 6. (965 aa)
RPA2RPA_C domain-containing protein. (270 aa)
COG4Conserved oligomeric Golgi complex subunit 4 isoform 1. (789 aa)
WDR83OSProtein Asterix; Belongs to the Asterix family. (110 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
ATP5F1DATP synthase subunit delta, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the c [...] (179 aa)
NDUFB6NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (188 aa)
NAALADL1N-acetylated alpha-linked acidic dipeptidase like 1. (773 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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