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KCNB1 KCNB1 LOC100156107 LOC100156107 PRX PRX KCNMA1 KCNMA1 LOC100522220 LOC100522220 TBC1D20 TBC1D20 BTBD6 BTBD6 EYA4 EYA4 FBN2 FBN2 CLCN4 CLCN4 BAX BAX VDAC3 VDAC3 TMEM114 TMEM114 PPL PPL PREB PREB CRYBB3 CRYBB3 MIF MIF VDAC2 VDAC2 AKR1E2 AKR1E2 BFSP2 BFSP2 LOC100739163 LOC100739163 MMP17 MMP17 DNASE2B DNASE2B CRYGS CRYGS LTBP2 LTBP2 EYA2 EYA2 FBN3 FBN3 KCNS1 KCNS1 CRYGD CRYGD LOC100154892 LOC100154892 CRYAB CRYAB VDAC1 VDAC1 AKR1B1 AKR1B1 KCNS3 KCNS3 KCNJ2 KCNJ2 LGSN LGSN GJA8 GJA8 GJA3 GJA3 VIM VIM CRYGC CRYGC VSX2 VSX2 MIP MIP
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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KCNB1Potassium voltage-gated channel subfamily B member 1; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Plays also a role in the regulation of exocytosis independently of its electrical function. Forms [...] (858 aa)
LOC100156107Uncharacterized protein; Belongs to the beta/gamma-crystallin family. (175 aa)
PRXPeriaxin. (1366 aa)
KCNMA1Calcium-activated potassium channel subunit alpha-1; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in t [...] (1288 aa)
LOC100522220Uncharacterized protein; Belongs to the beta/gamma-crystallin family. (174 aa)
TBC1D20TBC1 domain family member 20 isoform X1. (403 aa)
BTBD6BTB domain containing 6. (538 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (645 aa)
FBN2Fibrillin 2. (2910 aa)
CLCN4Chloride channel protein. (758 aa)
BAXTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family. (480 aa)
VDAC3Voltage-dependent anion-selective channel protein 3; Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules; Belongs to the eukaryotic mitochondrial porin family. (284 aa)
TMEM114Transmembrane protein 114. (223 aa)
PPLPeriplakin. (1925 aa)
PREBProlactin regulatory element binding. (418 aa)
CRYBB3Crystallin beta B3; Belongs to the beta/gamma-crystallin family. (211 aa)
MIFMacrophage migration inhibitory factor; Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By simi [...] (115 aa)
VDAC2Voltage-dependent anion-selective channel protein 2; Forms a channel through the cell membrane that allows diffusion from small hydrophilic molecules. (294 aa)
AKR1E21,5-anhydro-D-fructose reductase; Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D- fructose (AF) to 1,5-anhydro-D-glucitol. (301 aa)
BFSP2Beaded filament structural protein 2; Belongs to the intermediate filament family. (415 aa)
LOC100739163Glutathione S-transferase P; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity); Belongs to the GST superfamily. Pi family. (309 aa)
MMP17Matrix metalloproteinase-17 preproprotein. (595 aa)
DNASE2BDeoxyribonuclease 2 beta. (340 aa)
CRYGSCrystallin gamma S; Belongs to the beta/gamma-crystallin family. (186 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1814 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (583 aa)
FBN3Fibrillin 3. (2858 aa)
KCNS1Potassium voltage-gated channel modifier subfamily S member 1; Belongs to the potassium channel family. (568 aa)
CRYGDCrystallin gamma D; Belongs to the beta/gamma-crystallin family. (174 aa)
LOC100154892Uncharacterized protein; Belongs to the beta/gamma-crystallin family. (174 aa)
CRYABAlpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (237 aa)
VDAC1Voltage-dependent anion-selective channel protein 1; Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition p [...] (302 aa)
AKR1B1Aldo-keto reductase family 1 member B1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes th [...] (317 aa)
KCNS3Potassium voltage-gated channel subfamily S member 3 isoform X1; Belongs to the potassium channel family. (491 aa)
KCNJ2Inward rectifier potassium channel 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be bl [...] (427 aa)
LGSNLengsin, lens protein with glutamine synthetase domain; Belongs to the glutamine synthetase family. (507 aa)
GJA8Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (443 aa)
GJA3Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (380 aa)
VIMVimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. (469 aa)
CRYGCCrystallin gamma C; Belongs to the beta/gamma-crystallin family. (173 aa)
VSX2Visual system homeobox 2. (361 aa)
MIPMajor intrinsic protein of lens fiber; Belongs to the MIP/aquaporin (TC 1.A.8) family. (263 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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