(15 nodes) Tooth germ network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa)
	MMP20	Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation (By similarity). (483 aa)
	DMP1	Dentin matrix acidic phosphoprotein 1. (531 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	PAX9	Paired box 9. (394 aa)
	AMTN	Amelotin. (209 aa)
	AMBN	Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family. (421 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa)
	RUNX2	Runt-related transcription factor 2 isoform a. (625 aa)
	AMELY	Amelogenin; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family. (189 aa)
	RNF217	RBR-type E3 ubiquitin transferase. (541 aa)
	ENAM	142 kDa enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation. (1142 aa)
	MMP2	Uncharacterized protein. (610 aa)
	KLK4	Enamel matrix serine proteinase 1; Belongs to the peptidase S1 family. (254 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMBN	AMELY	ENSSSCP00000009536	ENSSSCP00000072463	Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family.	Amelogenin; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family.	0.978
AMBN	AMTN	ENSSSCP00000009536	ENSSSCP00000009535	Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family.	Amelotin.	0.941
AMBN	DMP1	ENSSSCP00000009536	ENSSSCP00000009831	Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family.	Dentin matrix acidic phosphoprotein 1.	0.507
AMBN	ENAM	ENSSSCP00000009536	ENSSSCP00000063311	Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family.	142 kDa enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation.	0.969
AMBN	KLK4	ENSSSCP00000009536	ENSSSCP00000019614	Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family.	Enamel matrix serine proteinase 1; Belongs to the peptidase S1 family.	0.916
AMBN	MMP20	ENSSSCP00000009536	ENSSSCP00000015906	Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family.	Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation (By similarity).	0.916
AMBN	RUNX2	ENSSSCP00000009536	ENSSSCP00000070509	Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family.	Runt-related transcription factor 2 isoform a.	0.592
AMELY	AMBN	ENSSSCP00000072463	ENSSSCP00000009536	Amelogenin; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family.	Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family.	0.978
AMELY	AMTN	ENSSSCP00000072463	ENSSSCP00000009535	Amelogenin; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family.	Amelotin.	0.937
AMELY	DMP1	ENSSSCP00000072463	ENSSSCP00000009831	Amelogenin; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family.	Dentin matrix acidic phosphoprotein 1.	0.621
AMELY	ENAM	ENSSSCP00000072463	ENSSSCP00000063311	Amelogenin; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family.	142 kDa enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation.	0.970
AMELY	KLK4	ENSSSCP00000072463	ENSSSCP00000019614	Amelogenin; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family.	Enamel matrix serine proteinase 1; Belongs to the peptidase S1 family.	0.952
AMELY	MMP20	ENSSSCP00000072463	ENSSSCP00000015906	Amelogenin; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family.	Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation (By similarity).	0.950
AMTN	AMBN	ENSSSCP00000009535	ENSSSCP00000009536	Amelotin.	Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family.	0.941
AMTN	AMELY	ENSSSCP00000009535	ENSSSCP00000072463	Amelotin.	Amelogenin; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family.	0.937
AMTN	DMP1	ENSSSCP00000009535	ENSSSCP00000009831	Amelotin.	Dentin matrix acidic phosphoprotein 1.	0.624
AMTN	ENAM	ENSSSCP00000009535	ENSSSCP00000063311	Amelotin.	142 kDa enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation.	0.945
AMTN	KLK4	ENSSSCP00000009535	ENSSSCP00000019614	Amelotin.	Enamel matrix serine proteinase 1; Belongs to the peptidase S1 family.	0.869
AMTN	MMP20	ENSSSCP00000009535	ENSSSCP00000015906	Amelotin.	Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation (By similarity).	0.849
DMP1	AMBN	ENSSSCP00000009831	ENSSSCP00000009536	Dentin matrix acidic phosphoprotein 1.	Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family.	0.507