STRINGSTRING
GABARAPL1 GABARAPL1 MAP1LC3B MAP1LC3B PIK3C3 PIK3C3 ATG14 ATG14 MAP1LC3A MAP1LC3A RUBCN RUBCN ATG3 ATG3 ATG13 ATG13 AMBRA1 AMBRA1 BECN1 BECN1 GABARAP GABARAP ATG10 ATG10 RB1CC1 RB1CC1 ATG4A ATG4A TAX1BP1 TAX1BP1 UVRAG UVRAG ATG4D ATG4D ATG16L1 ATG16L1 ATG101 ATG101 ATG7 ATG7 NBR1 NBR1 NRBF2 NRBF2 ULK1 ULK1 ATG12 ATG12 WIPI2 WIPI2 PIK3R4 PIK3R4 ATG4C ATG4C SQSTM1 SQSTM1 ATG4B ATG4B GABARAPL2 GABARAPL2 ULK2 ULK2 ATG5 ATG5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GABARAPL1Uncharacterized protein. (148 aa)
MAP1LC3BMicrotubule-associated protein 1 light chain 3 beta. (125 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Requ [...] (863 aa)
ATG14Autophagy related 14. (510 aa)
MAP1LC3AMicrotubule-associated protein 1 light chain 3 alpha. (121 aa)
RUBCNKIAA0226 protein transcript variant 2. (971 aa)
ATG3Autophagy-related protein 3. (320 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
AMBRA1Activating molecule in BECN1-regulated autophagy protein 1 isoform X1. (1296 aa)
BECN1Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] (461 aa)
GABARAPUncharacterized protein. (98 aa)
ATG10Autophagy related 10. (330 aa)
RB1CC1RB1 inducible coiled-coil 1. (1608 aa)
ATG4ACysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (489 aa)
TAX1BP1Tax1 binding protein 1. (814 aa)
UVRAGUV radiation resistance associated. (748 aa)
ATG4DCysteine protease ATG4D, mitochondrial; [Cysteine protease ATG4D]: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C- terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. (514 aa)
ATG16L1Autophagy-related protein 16-1 isoform X1. (623 aa)
ATG101Autophagy-related protein 101 isoform X1. (218 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (710 aa)
NBR1Next to BRCA1 gene 1 protein isoform X1. (960 aa)
NRBF2Nuclear receptor binding factor 2. (288 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1176 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
WIPI2WD repeat domain, phosphoinositide interacting 2. (559 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1302 aa)
ATG4CCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (458 aa)
SQSTM1Sequestosome 1. (451 aa)
ATG4BCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (402 aa)
GABARAPL2Uncharacterized protein. (187 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1073 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...] (287 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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