STRINGSTRING
VAC14 VAC14 PIP5KL1 PIP5KL1 PIP4P2 PIP4P2 PI4KB PI4KB INPP4A INPP4A PTEN PTEN PI4K2A PI4K2A INPP5F INPP5F PIP4K2A PIP4K2A INPPL1 INPPL1 PIK3C2B PIK3C2B MTMR4 MTMR4 SYNJ2 SYNJ2 I3LAC4_PIG I3LAC4_PIG PI4K2B PI4K2B PIK3C2A PIK3C2A FIG4 FIG4 PIK3C2G PIK3C2G MTMR1 MTMR1 PIP4P1 PIP4P1 PI4KA PI4KA SYNJ1 SYNJ1 SCIN SCIN MTMR7 MTMR7 PIP5K1C PIP5K1C PIKFYVE PIKFYVE INPP4B INPP4B MTMR3 MTMR3 SACM1L SACM1L PIP5K1B PIP5K1B OCRL OCRL PIP5K1A PIP5K1A PIP4K2C PIP4K2C PIP4K2B PIP4K2B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VAC14Protein VAC14 homolog isoform 1. (783 aa)
PIP5KL1Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform 1. (396 aa)
PIP4P2Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa)
PI4KBPhosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family. (841 aa)
INPP4AInositol polyphosphate-4-phosphatase type I A. (976 aa)
PTENUncharacterized protein. (576 aa)
PI4K2APhosphatidylinositol 4-kinase type 2-alpha. (479 aa)
INPP5FPhosphatidylinositide phosphatase SAC2 isoform 1. (1133 aa)
PIP4K2APhosphatidylinositol 5-phosphate 4-kinase type-2 alpha; Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of [...] (442 aa)
INPPL1Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling [...] (1265 aa)
PIK3C2BPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1634 aa)
MTMR4Myotubularin related protein 4. (1205 aa)
SYNJ2Synaptojanin 2. (1402 aa)
I3LAC4_PIGVac14_Fab1_bd domain-containing protein. (187 aa)
PI4K2BPhosphatidylinositol 4-kinase type 2 beta. (598 aa)
PIK3C2APhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1669 aa)
FIG4FIG4 phosphoinositide 5-phosphatase. (915 aa)
PIK3C2GPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family. (1511 aa)
MTMR1Myotubularin related protein 1. (671 aa)
PIP4P1Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (284 aa)
PI4KAPhosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family. (2072 aa)
SYNJ1Synaptojanin 1. (1576 aa)
SCINAdseverin; Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Severing activity is inhibited by phosphatidylinositol 4,5-bis- phosphate (PIP2) (By similarity). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (By similarity). Plays a role in osteoclastogenesis (OCG) and actin cytoskel [...] (715 aa)
MTMR7Myotubularin related protein 7. (659 aa)
PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X5. (702 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2055 aa)
INPP4BInositol polyphosphate-4-phosphatase type II B. (938 aa)
MTMR3Myotubularin related protein 3. (1215 aa)
SACM1LSAC1 like phosphatidylinositide phosphatase. (596 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (558 aa)
OCRLOCRL inositol polyphosphate-5-phosphatase. (903 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (584 aa)
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (529 aa)
PIP4K2BPhosphatidylinositol 5-phosphate 4-kinase type-2 beta. (416 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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