STRINGSTRING
PLCZ1 PLCZ1 ITPKC ITPKC PRKCG PRKCG HTT HTT TRPC3 TRPC3 MINPP1 MINPP1 INPP5A INPP5A INPP1 INPP1 PRKCA PRKCA PLCD3 PLCD3 INPP5K INPP5K ITPR2 ITPR2 IMPA1 IMPA1 ATXN2 ATXN2 MTM1 MTM1 PRKCB PRKCB PLCB4 PLCB4 ATXN2L ATXN2L TRPV5 TRPV5 ITPKB ITPKB ITPR3 ITPR3 PLCH1 PLCH1 PLCB2 PLCB2 ITPR1 ITPR1 ATXN3 ATXN3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCZ11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is t [...] (639 aa)
ITPKCKinase; Belongs to the inositol phosphokinase (IPK) family. (754 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (759 aa)
HTTHuntingtin. (3138 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (921 aa)
MINPP1Multiple inositol polyphosphate phosphatase 1 isoform 1; Belongs to the histidine acid phosphatase family. (485 aa)
INPP5AInositol polyphosphate-5-phosphatase A. (472 aa)
INPP1Inositol polyphosphate 1-phosphatase isoform X1. (402 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa)
PLCD3Phosphoinositide phospholipase C. (784 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (480 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2702 aa)
IMPA1Inositol monophosphatase 1; Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4- diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta- glycerophosphate, and 2'-AMP as substrates. (363 aa)
ATXN2Ataxin 2. (1335 aa)
MTM1Myotubularin isoform X3. (603 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
ATXN2LAtaxin 2 like. (1080 aa)
TRPV5Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family. (792 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (650 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2680 aa)
PLCH1Phosphoinositide phospholipase C. (1690 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2759 aa)
ATXN3Josephin domain-containing protein. (359 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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