(25 nodes) Mixed, incl. Interaction With Cumulus Cells And The Zona Pellucida, and Fertilization network (Sus scrofa)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ACRBP	Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin. (539 aa)
	CRISP1	Cysteine rich secretory protein 1; Belongs to the CRISP family. (249 aa)
	ADAM21	ADAM metallopeptidase domain 21. (735 aa)
	AQN-1	Carbohydrate-binding protein AQN-1; AQN proteins mediate the binding of boar spermatozoa to component(s) of the egg's zona pellucida by a carbohydrate-binding mechanism. AQN proteins are secretory components of the male accessory glands being coated to the sperm surface at the time of ejaculation. They possess as well heparin-, serine-protease-inhibitor-binding capability; Belongs to the spermadhesin family. (132 aa)
	BSP1	Seminal plasma protein pB1; May form a complex with spermadhesin AQN-1 which possesses phosphorylcholine-binding activity. (152 aa)
	ZNF575	Zinc finger protein 575. (327 aa)
	LYPD3	Ly6/PLAUR domain-containing protein 3. (346 aa)
	ELSPBP1	Epididymal sperm-binding protein 1; Binds to spermatozoa upon ejaculation and may play a role in sperm capacitation. Has phosphorylcholine-binding activity. (223 aa)
	CABP5	Calcium binding protein 5. (173 aa)
	ADAM30	ADAM metallopeptidase domain 30. (727 aa)
	ANKRD60	Orthologue of H. sapiens chromosome 20 open reading frame 86. (241 aa)
	ZP3	Processed zona pellucida sperm-binding protein 3; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for zona matrix formation. May not have a sperm- binding activity by itself but may increase sperm-binding activity of ZPB. (421 aa)
	ZP2	Processed zona pellucida sperm-binding protein 2; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor. Belongs to the ZP domain family. ZPA subfamily. (716 aa)
	ZP4	Processed zona pellucida sperm-binding protein 4; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor. (536 aa)
	ADAM2	Fertilin beta. (735 aa)
	SPAM1	Hyaluronidase. (493 aa)
	LRRC63	Leucine rich repeat containing 63. (578 aa)
	PCSK4	Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (834 aa)
	ADAM20	ADAM metallopeptidase domain 20. (737 aa)
	OVGP1	Oviduct-specific glycoprotein; Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development. (519 aa)
	TEX101	Uncharacterized protein. (248 aa)
	PHLDB3	Pleckstrin homology like domain family B member 3. (638 aa)
	CCDC74B	Uncharacterized protein. (316 aa)
	ZPBP2	Zona pellucida binding protein 2. (363 aa)
	ZAN	Zonadhesin; Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling. (2676 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACRBP	ADAM2	ENSSSCP00000000746	ENSSSCP00000016751	Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.	Fertilin beta.	0.605
ACRBP	ADAM20	ENSSSCP00000000746	ENSSSCP00000036851	Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.	ADAM metallopeptidase domain 20.	0.481
ACRBP	AQN-1	ENSSSCP00000000746	ENSSSCP00000003226	Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.	Carbohydrate-binding protein AQN-1; AQN proteins mediate the binding of boar spermatozoa to component(s) of the egg's zona pellucida by a carbohydrate-binding mechanism. AQN proteins are secretory components of the male accessory glands being coated to the sperm surface at the time of ejaculation. They possess as well heparin-, serine-protease-inhibitor-binding capability; Belongs to the spermadhesin family.	0.760
ACRBP	BSP1	ENSSSCP00000000746	ENSSSCP00000003307	Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.	Seminal plasma protein pB1; May form a complex with spermadhesin AQN-1 which possesses phosphorylcholine-binding activity.	0.419
ACRBP	CRISP1	ENSSSCP00000000746	ENSSSCP00000001895	Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.	Cysteine rich secretory protein 1; Belongs to the CRISP family.	0.469
ACRBP	ELSPBP1	ENSSSCP00000000746	ENSSSCP00000003383	Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.	Epididymal sperm-binding protein 1; Binds to spermatozoa upon ejaculation and may play a role in sperm capacitation. Has phosphorylcholine-binding activity.	0.453
ACRBP	SPAM1	ENSSSCP00000000746	ENSSSCP00000017585	Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.	Hyaluronidase.	0.442
ACRBP	ZAN	ENSSSCP00000000746	ENSSSCP00000067423	Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.	Zonadhesin; Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling.	0.620
ACRBP	ZP3	ENSSSCP00000000746	ENSSSCP00000008213	Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.	Processed zona pellucida sperm-binding protein 3; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for zona matrix formation. May not have a sperm- binding activity by itself but may increase sperm-binding activity of ZPB.	0.483
ACRBP	ZPBP2	ENSSSCP00000000746	ENSSSCP00000066711	Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.	Zona pellucida binding protein 2.	0.798
ADAM2	ACRBP	ENSSSCP00000016751	ENSSSCP00000000746	Fertilin beta.	Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.	0.605
ADAM2	ADAM20	ENSSSCP00000016751	ENSSSCP00000036851	Fertilin beta.	ADAM metallopeptidase domain 20.	0.858
ADAM2	ADAM21	ENSSSCP00000016751	ENSSSCP00000002520	Fertilin beta.	ADAM metallopeptidase domain 21.	0.843
ADAM2	ADAM30	ENSSSCP00000016751	ENSSSCP00000007159	Fertilin beta.	ADAM metallopeptidase domain 30.	0.822
ADAM2	CRISP1	ENSSSCP00000016751	ENSSSCP00000001895	Fertilin beta.	Cysteine rich secretory protein 1; Belongs to the CRISP family.	0.566
ADAM2	ELSPBP1	ENSSSCP00000016751	ENSSSCP00000003383	Fertilin beta.	Epididymal sperm-binding protein 1; Binds to spermatozoa upon ejaculation and may play a role in sperm capacitation. Has phosphorylcholine-binding activity.	0.478
ADAM2	LRRC63	ENSSSCP00000016751	ENSSSCP00000024881	Fertilin beta.	Leucine rich repeat containing 63.	0.499
ADAM2	OVGP1	ENSSSCP00000016751	ENSSSCP00000039660	Fertilin beta.	Oviduct-specific glycoprotein; Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development.	0.603
ADAM2	PCSK4	ENSSSCP00000016751	ENSSSCP00000027290	Fertilin beta.	Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family.	0.465
ADAM2	SPAM1	ENSSSCP00000016751	ENSSSCP00000017585	Fertilin beta.	Hyaluronidase.	0.786